Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1383&sort=abstract
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=abstract", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1424&sort=abstract", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=abstract", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1382&sort=abstract" }, "data": [ { "type": "Grant", "id": "7608", "attributes": { "award_id": "3R01AG030611-13S1", "title": "COVID-19 Supplement to LitCog IV: Health Literacy and Cognitive Function Among Older Adults", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 20821, "first_name": "JONATHAN W.", "last_name": "KING", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2007-09-15", "end_date": "2025-02-28", "award_amount": 391278, "principal_investigator": { "id": 21022, "first_name": "MICHAEL S", "last_name": "WOLF", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 924, "ror": "", "name": "NORTHWESTERN UNIVERSITY AT CHICAGO", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 924, "ror": "", "name": "NORTHWESTERN UNIVERSITY AT CHICAGO", "address": "", "city": "", "state": "IL", "zip": "", "country": "United States", "approved": true }, "abstract": "We are seeking a supplement to our ongoing study (‘LitCog’; R01AG030611) in order to conduct two parallel, complementary investigations of the longer-term impact of COVID-19 on older adults’ lifestyle behaviors, psychological & physical function, socioeconomic circumstances, healthcare use, access & adherence to treatment, and health outcomes. First, we will extend our current inquiries to now determine whether LitCog participants with cognitive impairment are experiencing greater challenges in accessing care and managing personal health due to COVID-19 compared to cognitively ‘normal’ adults. Such a natural experiment is possible with LitCog; since 2007 we have tracked declines in cognition, as well as onset of cognitive impairment, and the resulting impact on self-management of chronic conditions among diverse, community dwelling, older adults. We will leverage our recent renewal award, with data capture from active patients (N=776), involved caregivers (N=100), electronic health (EHR) and pharmacy records, and add 5 telephone interviews conducted every 4 months to address the following primary aim: Aim 1 Investigate whether poorer cognitive function or MCI prior to the COVID-19 outbreak is associated with inadequate use of healthcare services and/or poorer health status. Second, we will also extend our LitCog-linked, Chicago COVID-19 Comorbidities (C3) cohort study. In March 2020, as cases of COVID-19 were emerging in Chicago, our team rapidly responded by launching a survey to understand how older adults with chronic conditions, at greater risk for COVID-19 complications, were responding and taking action (or not) to prevent infection and disease spread. LitCog participants (n=153), as well as patients enrolled in four other active studies (N=673) with uniform data collection for a large set of patient factors and similar access to EHR and pharmacy records were recruited. Interviews were conducted during Chicago’s COVID-19 outbreak phase (March 13-20), rapid acceleration phase (March 27-April 3), and apex phase (May 1-19). Our findings revealed many high risk adults lacked critical knowledge of COVID-19 symptoms and ways to prevent harm, did not feel susceptible to the virus, felt unprepared for the outbreak, were not social distancing or ensuring they had adequate supplies of prescribed medications. Disparities were revealed; black adults, those living below poverty level, with low health literacy and poorer cognition were less prepared. Moving forward, the C3 cohort will also be followed as the LitCog cohort in Aim 1, allowing us to combine both cohorts and more directly investigate the longer-term impact of stress due to COVID-19 on the health and behaviors of adults with chronic conditions. Our secondary aim is to: Aim 2 Examine adults’ perceived stress from COVID-19 and its associations with lifestyle & self- management behaviors, healthcare use, patient-reported and clinical outcomes over time.", "keywords": [ "Acceleration", "Address", "Adherence", "Adult", "Affect", "Award", "Behavior", "Businesses", "COVID-19", "Caregivers", "Chicago", "Chronic", "Chronic Disease", "Clinical", "Cognition", "Cognitive", "Cohort Studies", "Communities", "Data", "Data Collection", "Disease", "Disease Outbreaks", "Disease Outcome", "Elderly", "Enrollment", "Ensure", "Exhibits", "Health", "Health Services Accessibility", "Health Status", "Health behavior", "Healthcare", "Illinois", "Impaired cognition", "Individual", "Infection prevention", "Interview", "Investigation", "Knowledge", "Life", "Life Style", "Link", "Mediating", "Natural experiment", "Outcome", "Participant", "Patients", "Pharmaceutical Preparations", "Pharmacy facility", "Phase", "Physical Function", "Poverty", "Procedures", "Reaction", "Records", "Reporting", "Risk", "Self Care", "Self Management", "Services", "Shelter facility", "Social Change", "Social Distance", "Social isolation", "Social support", "Socioeconomic Status", "Stress", "Surveys", "Symptoms", "Telephone", "Telephone Interviews", "Time", "Virus", "Visit", "Work", "anxiety symptoms", "cognitive function", "cohort", "comorbidity", "depressive symptoms", "experience", "follow-up", "health care availability", "health care disparity", "health care service utilization", "health disparity", "health literacy", "health management", "high risk", "mild cognitive impairment", "pandemic disease", "patient portal", "perceived stress", "physical conditioning", "prevent", "psychologic", "recruit", "remote health care", "social", "socioeconomics", "telehealth", "treatment adherence" ], "approved": true } }, { "type": "Grant", "id": "15703", "attributes": { "award_id": "1R13DC022794-01", "title": "The 10th International Symposium on Middle Ear Mechanics in Research and Otology (MEMRO 2025)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Deafness and Other Communication Disorders (NIDCD)" ], "program_reference_codes": [], "program_officials": [ { "id": 32571, "first_name": "BRACIE", "last_name": "WATSON", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2025-06-01", "end_date": "2026-05-31", "award_amount": 51000, "principal_investigator": { "id": 32572, "first_name": "STEPHEN", "last_name": "CASS", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 32573, "first_name": "Nathaniel Tussing", "last_name": "Greene", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 32574, "first_name": "Daniel J", "last_name": "Tollin", "orcid": "", "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 784, "ror": "https://ror.org/02hh7en24", "name": "University of Colorado Denver", "address": "", "city": "", "state": "CO", "zip": "", "country": "United States", "approved": true }, "abstract": "We are seeking partial support through this proposal to cover the expenses for the 10th International Meeting of the Middle Ear Mechanics in Research and Otology (MEMRO) 2025 conference, scheduled for June 2025 at the KU Leuven, in Belgium. In alignment with the objectives established at the inaugural MEMRO meeting in 1996, the purpose of this triennial event is to bring together experts in middle ear science and engineering with clinical otologists to facilitate an exchange of knowledge and ideas between these typically independent groups. Previous MEMRO meetings in Shanghai (2018) and Denmark (2015) each attracted approximately 200 participants from over 20 countries. The 2022 meeting had slightly fewer participants since scientists from many countries, including China, Japan, Australia, and others, that would normally attend the MEMRO meetings were still precluded from travel due to COVID restrictions. We expect the 10th edition to have a higher attendance. The 2025 meeting aims to continue promoting the free exchange of ideas between basic and clinical scientists and to establish a framework for innovative collaborative efforts to enhance our understanding of middle ear function, dysfunction, and repair. A primary goal of this meeting is to increase the diversity of attendees, with a particular focus on engaging otology residents and faculty by hosting a hands-on workshop on methods and technologies the day prior to the formal conference. Also many efforts have been made to increase the presence of underrepresented countries. We have promoted the conference on multiple occasions on other world conferences. We have representatives from all continents in the scientific committee. The 2025 MEMRO meeting is being organized by KU Leuven, Belgium's largest and highest-ranked university and is an excellent center for education, research and Innovation. Leuven is a vibrant city only 15 minutes by train from Brussels Airport allowing easy travel, and is rich in art, history, and architecture, offering attendees ample opportunities to experience this dynamic international city.", "keywords": [ "Acoustics", "Architecture", "Australia", "Basic Science", "Belgium", "Biology", "Biomechanics", "Biophysics", "COVID-19", "China", "Cities", "Clinical", "Cochlear Implants", "Collaborations", "Communication", "Conductive hearing loss", "Country", "Denmark", "Diagnosis", "Disabling", "Disadvantaged", "Disease", "Ear", "Economics", "Education", "Educational workshop", "Emerging Technologies", "Employment", "Engineering", "Event", "External auditory canal", "Faculty", "Fostering", "Functional disorder", "Goals", "Hearing", "Hearing Aids", "Implant", "Individual", "International", "Japan", "Knowledge", "Labyrinth", "Lead", "Mechanics", "Medical", "Methods", "Operative Surgical Procedures", "Otolaryngologist", "Otology", "Outcome", "Participant", "Pathogenesis", "Pathologic", "Pathology", "Process", "Recording of previous events", "Research", "Research Personnel", "Schedule", "Science", "Scientist", "Sensory", "Social isolation", "Stimulus", "Structure", "Students", "Surgeon", "Technology", "Training", "Travel", "Tympanic membrane", "Universities", "Vision", "World Health Organization", "experience", "hearing impairment", "improved", "innovation", "interest", "meetings", "microphone", "middle ear", "middle ear disorder", "multidisciplinary", "neural", "repaired", "symposium", "technological innovation" ], "approved": true } }, { "type": "Grant", "id": "9818", "attributes": { "award_id": "1R24OD033726-01", "title": "Vivarium Modernization with Digital Ventilated Cages to Enhance Research Capacity and Reproducibility, and Provide Cage Environment Monitoring for Improved Operational Efficiency and Animal Welfare", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 23882, "first_name": "CHARLES ASHLEY", "last_name": "Barnes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2022-08-01", "end_date": "2023-07-31", "award_amount": 400000, "principal_investigator": { "id": 25680, "first_name": "Theodore F", "last_name": "Taraschi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1548, "ror": "https://ror.org/00ysqcn41", "name": "Thomas Jefferson University", "address": "", "city": "", "state": "PA", "zip": "", "country": "United States", "approved": true }, "abstract": "We are seeking support to purchase and install an integrated digital ventilated cage system to enhance operational efficacy and modernize and strengthen the research-supporting operations of an existing, more than twenty-five-year-old shared-use ABSL3 facility. This FOA is timely, since the addition of the integrated Digital Ventilated Cage (DVC®) system we are requesting would synergize with our ongoing institutional strategic plan to modernize existing vivarium facilities, and have broad benefits for the institutional research community. The static microisolator caging system currently in use is suboptimal and antiquated and cannot meet the current or future needs of the large number of investigators from different disciplines performing ABSL3 work with animals infected with SAR2-Covid, SARS-Covid variants and other BL3 agents. The DVC® is a unique and revolutionary home-cage monitoring system composed of a mix of electronics and software components to collect a set of information directly from the home cage. We selected this system with the goals of 1) improving the shared-use facility operational efficiency and 2) enhancing animal welfare management. Furthermore, 3) the unique detection system collects extrinsic environmental conditions (temperature, humidity, noise and vibration, human intervention, etc.) in the home cages. These factors are likely to have effects on experiments using animals and reporting them in publications as a general practice could contribute to improved research quality (rigor and reproducibility). The modernization of an outdated ABSL3 facility to a more secure one containing a state-of-the-art integrated digital ventilated cage system in two animal housing rooms. This equipment modernization will combine and potentially synergize with institutionally-funded modernization efforts slated to be completed within the next six months – for example, the modernized animal housing caging system will be located in rooms adjacent to and with direct access to a modernized BL3 suite for tissue processing and specimen processing. Therefore, our proposed equipment modernization is a critical step towards meeting the needs of current and future investigators from diverse disciplines using rodent animal models for research involving an increasing number of BL3 pathogens.", "keywords": [ "2019-nCoV", "5 year old", "Address", "Administrator", "Aging", "Air", "Air Movements", "Animal Experimentation", "Animal Housing", "Animal Model", "Animal Welfare", "Animals", "Biomedical Research", "Censuses", "Communicable Diseases", "Communities", "Computer software", "Containment", "Data", "Discipline", "Electronics", "Engineering", "Ensure", "Environment", "Equipment", "Food", "Funding", "Future", "General Practices", "Goals", "Health", "Home", "Housing", "Human", "Human Resources", "Humidity", "Individual", "Infectious Agent", "Infectious Diseases Research", "Intervention", "Investments", "KAI1 gene", "Laboratory Animal Production and Facilities", "Lighting", "Lymphocytic choriomeningitis virus", "Modernization", "Monitor", "Noise", "Personal Satisfaction", "Powassan virus", "Process", "Publications", "Rabies", "Reporting", "Reproducibility", "Research", "Research Personnel", "Research Support", "Risk Reduction", "Rodent", "Schedule", "Science", "Secure", "Services", "Severe Acute Respiratory Syndrome", "Specimen Handling", "Standardization", "Strategic Planning", "Stress", "System", "Temperature", "Time", "Tissue Sample", "Universities", "Update", "Vaccinia", "Variant", "Water", "Work", "animal care", "animal data", "animal facility", "base", "biosecurity", "coronavirus disease", "detection platform", "digital", "experimental study", "high efficiency particulate air filter", "humane endpoint", "improved", "influenzavirus", "meetings", "operation", "pathogen", "programs", "research study", "response", "sample collection", "sensor", "tissue processing", "ventilation", "vibration" ], "approved": true } }, { "type": "Grant", "id": "7716", "attributes": { "award_id": "1ZIAAG000443-13", "title": "The origin of tBregs and their trans-differentiation in cancer", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [], "start_date": null, "end_date": null, "award_amount": 1596810, "principal_investigator": { "id": 23510, "first_name": "Arya", "last_name": "Biragyn", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1613, "ror": "https://ror.org/049v75w11", "name": "National Institute on Aging", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1613, "ror": "https://ror.org/049v75w11", "name": "National Institute on Aging", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "We continue our study of regulatory B cells, which we discovered in some mice and humans with cancer (Olkhanud et al, Cancer Research, 2011; Bodogai et al. Cancer Research, 2013). These cells (termed tBregs) are directly induced by cancer cells producing metabolites of 5-lipoxygenase pathway (5-LOX) via activating the proliferator-activated receptor alpha (PPARa) signaling in B cells (Wejksza et al., J. Immunology, 2013). tBregs express high levels of TGFb and support cancer metastasis utilizing several mechanisms, such as by suppressing activity of effector T cells, inducing the generation of FoxP3+ Tregs, and educating the regulatory function of both the monocyte and granulocyte subpopulations of MDSCs via triggering TgfbR1/TgfbR2 signaling. Although Tregs and MDSCs are the key metastasis-supporting cells, our data place tBregs upstream of these two cells, explain why the loss of tBregs alone almost completely abrogates metastasis (Bodogai et al., Cancer Research, 2015; Olkhanud et al, Cancer Research, 2011). Overall, our data indicate that cancer-induced B cells/B regulatory cells play important roles in metastasis (Bodogai et al., Cancer Research, 2015), suggesting that strategies that inactivate tBregs can improve antitumor immune responses (Lee-Chang et al., J. Immunol., 2013; Bodogai et al., Cancer Research, 2013). However, we also demonstrated that some B cell-targeting strategies can instead be harmful. For example, because tBregs express low levels of surface CD20, current FDA-approved antibody that depletes B cells by targeting CD20 (Rituximab/Rituxan) eliminates beneficial B cells but enriches for tBregs and thereby exacerbates metastasis in mice (Bodogai et al., Cancer Research, 2013), explaining a recent failure of this strategy in humans with solid tumors. The source of B cells that become tBregs remained unknown. Here, we report completion of 4-year-long study that revealed that tBregs are derived from the bone marrow (BM) pre-B cells. Mechanistically, cancer promotes premature emigration of pre-B cells from BM and expansion in the circulation by producing thymic stromal lymphopoietin (TSLP). TSLP downregulates CXCR4 and VLA4 expression on pre-B cells and dislodges them from BM. In addition, TSLP also supports survival of pre-B cells in the circulation. Overall, our study revealed previously unknown pathway that cancer utilizes to generate metastasis-promoting regulatory B cells. Moreover, it also suggested that the TSLP/TSLPR axis can be a therapeutic target to control cancer metastasis, because the loss of TSLP expression in cancer cells or TSLPR deficiency in B cells impairs lung metastasis of 4T1 cancer cells. This finding is recently published in Cancer Research (Ragganoud et al, 2019). \tThe second part of this study is to understand the differentiation of pre-B cells in the circulation. We found that these cells can surprisingly trans-differentiate into macrophage-like cells. At present, we are elucidating the mechanism of this unique process and its relevance to cancer escape. Unfortunately, the COVID-19 quarantine temporarily hampered the progress of this exciting study. Several essential strains of mice we were breeding for this study were lost due to the COVI-19 rules of our animal facility. We therefore expect to complete this study and submit paper for publication sometime late 2021.", "keywords": [ "4T1", "Antibodies", "Arachidonate 5-Lipoxygenase", "B-Lymphocytes", "Blood Circulation", "Bone Marrow", "Breeding", "COVID-19", "CXCR4 gene", "Cancer Control", "Cells", "Data", "Emigrations", "FDA approved", "FOXP3 gene", "Failure", "Generations", "Goals", "Human", "Immunology", "Impairment", "LOX gene", "Lung", "MS4A1 gene", "Malignant Neoplasms", "Metastatic Neoplasm to the Lung", "Mouse Strains", "Mus", "Neoplasm Metastasis", "Paper", "Pathway interactions", "Phenotype", "Play", "Process", "Publications", "Publishing", "Quarantine", "Regulatory T-Lymphocyte", "Reporting", "Role", "Signal Transduction", "Solid Neoplasm", "Source", "Supporting Cell", "Surface", "TSLP gene", "Testing", "animal facility", "anti-tumor immune response", "anticancer research", "cancer cell", "effector T cell", "granulocyte", "improved", "macrophage", "malignant breast neoplasm", "monocyte", "premature", "receptor", "rituximab", "therapeutic target", "transdifferentiation" ], "approved": true } }, { "type": "Grant", "id": "8370", "attributes": { "award_id": "1U54CK000613-01", "title": "Infection Prevention and Antimicrobial Stewardship: Minding the Gaps: The Iowa Prevention Epicenter", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-06-01", "end_date": "2026-05-31", "award_amount": 545782, "principal_investigator": { "id": 24153, "first_name": "Loreen A", "last_name": "Herwaldt", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 220, "ror": "https://ror.org/036jqmy94", "name": "University of Iowa", "address": "", "city": "", "state": "IA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 220, "ror": "https://ror.org/036jqmy94", "name": "University of Iowa", "address": "", "city": "", "state": "IA", "zip": "", "country": "United States", "approved": true }, "abstract": "We designed this proposal to address multiple CDC Epicenters' research priorities: preventing healthcare personnel (HCP) contamination, understanding and decreasing transmission of epidemiologically important pathogens including emerging respiratory viruses such as COVID-19, extending antimicrobial stewardship (AS), decreasing antimicrobial resistant infections, exploring sepsis epidemiology and prevention, quantifying and decreasing environmental contamination, implementing a decolonization program to obtain source control and decrease surgical site infections (SSI), applying innovative research methodology, and training the next generation of healthcare epidemiologists. Our proposed projects range from translational stage T0 to T2 and involve academic medical centers, a VA Medical Center, acute care hospitals, quick/urgent care centers (UCC), surgical patients, patients discharged from hospitals, and healthcare personnel (HCP) exposed to viral respiratory pathogens. Our long-term objectives are to: 1) improve the integration of infection prevention measures into HCP's patient care processes, 2) improve personal protective equipment (PPE) design and use to decrease HCP contamination and transmission, 3) improve surveillance for healthcare-associated infections (HAI), 4) identify practical ways to decrease spread of viral pathogens, 4) improve antibiotic use and decrease antimicrobial resistance, and 5) prevent hospital-onset sepsis (HOS) and HAI, including SSI. Core Project (CP) I uses methods from human factors engineering, ethnography, industrial hygiene, environmental microbiology, and computer visioning to improve PPE design, decrease HCP self-contamination, improve integration of PPE use and hand hygiene during patient care, and decrease bacterial and viral environmental contamination. CP II employs novel software via cellphones to expand surveillance for SSI and C. difficile infections after discharge and to monitor HCP exposed to respiratory viruses for signs or symptoms of infection. CP III and the Medium Optional Collaborative Project (OCP) address neglected opportunities for AS--UCC and patients at hospital discharge--by creating and testing novel AS metrics to decrease antibiotic prescriptions for acute respiratory tract infections in UCC (CP III) and by conducting a cluster-randomized trial of post-prescription audit-and-review to reduce unnecessary antibiotic use after discharge (Medium OCP). CP IV mines large administrative data sets and analyzes data from individual medical records to define the epidemiology of HOS, validate CDC's acute sepsis event algorithm for HOS, and identify remediable HOS risk factors that could be targets for preventive measures. The Large OCP will conduct a stepped wedge trial of a simple, inexpensive intervention—2 doses of intranasal povidone iodine—to prevent SSI in patients with high- energy lower extremity fractures, who are a high-risk population with few available preventive measures. The Small OCP seeks to improve antibiograms and, therefore, antibiotic use by including geospatial information in antibiograms. This information should provide clinicians with information more specific to their patients.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "9836", "attributes": { "award_id": "5U54CK000613-02", "title": "Infection Prevention and Antimicrobial Stewardship: Minding the Gaps: The Iowa Prevention Epicenter", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-06-01", "end_date": "2026-05-31", "award_amount": 1613024, "principal_investigator": { "id": 24153, "first_name": "Loreen A", "last_name": "Herwaldt", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 220, "ror": "https://ror.org/036jqmy94", "name": "University of Iowa", "address": "", "city": "", "state": "IA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 220, "ror": "https://ror.org/036jqmy94", "name": "University of Iowa", "address": "", "city": "", "state": "IA", "zip": "", "country": "United States", "approved": true }, "abstract": "We designed this proposal to address multiple CDC Epicenters' research priorities: preventing healthcare personnel (HCP) contamination, understanding and decreasing transmission of epidemiologically important pathogens including emerging respiratory viruses such as COVID-19, extending antimicrobial stewardship (AS), decreasing antimicrobial resistant infections, exploring sepsis epidemiology and prevention, quantifying and decreasing environmental contamination, implementing a decolonization program to obtain source control and decrease surgical site infections (SSI), applying innovative research methodology, and training the next generation of healthcare epidemiologists. Our proposed projects range from translational stage T0 to T2 and involve academic medical centers, a VA Medical Center, acute care hospitals, quick/urgent care centers (UCC), surgical patients, patients discharged from hospitals, and healthcare personnel (HCP) exposed to viral respiratory pathogens. Our long-term objectives are to: 1) improve the integration of infection prevention measures into HCP's patient care processes, 2) improve personal protective equipment (PPE) design and use to decrease HCP contamination and transmission, 3) improve surveillance for healthcare-associated infections (HAI), 4) identify practical ways to decrease spread of viral pathogens, 4) improve antibiotic use and decrease antimicrobial resistance, and 5) prevent hospital-onset sepsis (HOS) and HAI, including SSI. Core Project (CP) I uses methods from human factors engineering, ethnography, industrial hygiene, environmental microbiology, and computer visioning to improve PPE design, decrease HCP self-contamination, improve integration of PPE use and hand hygiene during patient care, and decrease bacterial and viral environmental contamination. CP II employs novel software via cellphones to expand surveillance for SSI and C. difficile infections after discharge and to monitor HCP exposed to respiratory viruses for signs or symptoms of infection. CP III and the Medium Optional Collaborative Project (OCP) address neglected opportunities for AS--UCC and patients at hospital discharge--by creating and testing novel AS metrics to decrease antibiotic prescriptions for acute respiratory tract infections in UCC (CP III) and by conducting a cluster-randomized trial of post-prescription audit-and-review to reduce unnecessary antibiotic use after discharge (Medium OCP). CP IV mines large administrative data sets and analyzes data from individual medical records to define the epidemiology of HOS, validate CDC's acute sepsis event algorithm for HOS, and identify remediable HOS risk factors that could be targets for preventive measures. The Large OCP will conduct a stepped wedge trial of a simple, inexpensive intervention—2 doses of intranasal povidone iodine—to prevent SSI in patients with high- energy lower extremity fractures, who are a high-risk population with few available preventive measures. The Small OCP seeks to improve antibiograms and, therefore, antibiotic use by including geospatial information in antibiograms. This information should provide clinicians with information more specific to their patients.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8401", "attributes": { "award_id": "1U54CK000602-01", "title": "Intermountain Program on Antibiotic Resistance and microbial Threats (IMPART)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-06-01", "end_date": "2026-05-31", "award_amount": 546000, "principal_investigator": { "id": 24169, "first_name": "MICHAEL A.", "last_name": "RUBIN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 202, "ror": "https://ror.org/03r0ha626", "name": "University of Utah", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24170, "first_name": "MATTHEW H", "last_name": "SAMORE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 202, "ror": "https://ror.org/03r0ha626", "name": "University of Utah", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true }, "abstract": "We enthusiastically propose to renew our CDC Prevention Epicenter, entitled “InterMountain Program in Antibiotic Resistance and microbial Threats (IMPART). Our proposal assembles an exceptional group of investigators who have an extraordinary capacity to conduct large-scale observational studies, as well as lead or co-lead interventional studies that range in scope from small pilots to multi-community randomized trials The University of Utah is the hub for our program, with Intermountain Health, a large regional integrated health system, serving as a major node. The Veterans Affairs (VA) Salt Lake City Healthcare System is another key partner for our Prevention Epicenter site, operating within a programmatic network that encompasses the entire VA health system. The resources that we bring to the CDC Prevention Epicenter Program will be broadly beneficial to its mission to improve healthcare safety and prevent healthcare-associated infection. We have accumulated the experience in translational research and expertise in multi-disciplinary methods to make significant contributions to improve the quality of antibiotic use, combat antibiotic resistance, and enhance health system response to microbial threats across the continuum of care. Moreover, we have developed a computational environment to support comprehensive epidemiological analysis of infections within the Department of Veterans Affairs (VA) Health System, as well as Intermountain Healthcare and University of Utah Health (UHealth). Our proposed research has a high level of significance for policy-making and implementation. Core Project 1 evaluates alternative implementation strategies for outpatient stewardship and advances dissemination of best practices for AS. Core Project 2 tackles a longstanding source of controversy in the healthcare epidemiology community, namely, the role of active surveillance and contact precautions (CP) in preventing healthcare-associated infection due to endemic multi-drug resistant organisms (MDRO) such as methicillin-resistant Staphylococcus aureus (MRSA). A period of partial CP deimplementation in some VA facilities, triggered in response to the emergence of COVID-19, creates the opportunity to study the impact of this natural experiment. Core Project 3 links an epidemiological analysis of transmission pathways in LTC facilities to the development and implementation of novel approaches to improve practice. Core Project 4 confronts the global health challenge of COVID-19, to enhance preparedness for future epidemics and increase understanding of how to control healthcare spread of both seasonal and novel viruses. We are committed to active engagement with other Prevention Epicenter sites on collaborative projects and to work closely with public health entities at national, state, and local levels. We also pledge to contribute to programmatic domains and pathogen-specific workgroups set up under the auspices of the Prevention Epicenter Program. For all of our activities, close alignment with the health priorities of CDC will be established, along with substantial programmatic involvement of CDC staff.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8402", "attributes": { "award_id": "5U54CK000602-02", "title": "Intermountain Program on Antibiotic Resistance and microbial Threats (IMPART)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-06-01", "end_date": "2026-05-31", "award_amount": 865508, "principal_investigator": { "id": 24169, "first_name": "MICHAEL A.", "last_name": "RUBIN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 202, "ror": "https://ror.org/03r0ha626", "name": "University of Utah", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24170, "first_name": "MATTHEW H", "last_name": "SAMORE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 202, "ror": "https://ror.org/03r0ha626", "name": "University of Utah", "address": "", "city": "", "state": "UT", "zip": "", "country": "United States", "approved": true }, "abstract": "We enthusiastically propose to renew our CDC Prevention Epicenter, entitled “InterMountain Program in Antibiotic Resistance and microbial Threats (IMPART). Our proposal assembles an exceptional group of investigators who have an extraordinary capacity to conduct large-scale observational studies, as well as lead or co-lead interventional studies that range in scope from small pilots to multi-community randomized trials The University of Utah is the hub for our program, with Intermountain Health, a large regional integrated health system, serving as a major node. The Veterans Affairs (VA) Salt Lake City Healthcare System is another key partner for our Prevention Epicenter site, operating within a programmatic network that encompasses the entire VA health system. The resources that we bring to the CDC Prevention Epicenter Program will be broadly beneficial to its mission to improve healthcare safety and prevent healthcare-associated infection. We have accumulated the experience in translational research and expertise in multi-disciplinary methods to make significant contributions to improve the quality of antibiotic use, combat antibiotic resistance, and enhance health system response to microbial threats across the continuum of care. Moreover, we have developed a computational environment to support comprehensive epidemiological analysis of infections within the Department of Veterans Affairs (VA) Health System, as well as Intermountain Healthcare and University of Utah Health (UHealth). Our proposed research has a high level of significance for policy-making and implementation. Core Project 1 evaluates alternative implementation strategies for outpatient stewardship and advances dissemination of best practices for AS. Core Project 2 tackles a longstanding source of controversy in the healthcare epidemiology community, namely, the role of active surveillance and contact precautions (CP) in preventing healthcare-associated infection due to endemic multi-drug resistant organisms (MDRO) such as methicillin-resistant Staphylococcus aureus (MRSA). A period of partial CP deimplementation in some VA facilities, triggered in response to the emergence of COVID-19, creates the opportunity to study the impact of this natural experiment. Core Project 3 links an epidemiological analysis of transmission pathways in LTC facilities to the development and implementation of novel approaches to improve practice. Core Project 4 confronts the global health challenge of COVID-19, to enhance preparedness for future epidemics and increase understanding of how to control healthcare spread of both seasonal and novel viruses. We are committed to active engagement with other Prevention Epicenter sites on collaborative projects and to work closely with public health entities at national, state, and local levels. We also pledge to contribute to programmatic domains and pathogen-specific workgroups set up under the auspices of the Prevention Epicenter Program. For all of our activities, close alignment with the health priorities of CDC will be established, along with substantial programmatic involvement of CDC staff.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "6999", "attributes": { "award_id": "3R01ES026994-05S1", "title": "COVID-19 Pandemic among low-income Latino families in an agricultural community: Financial, occupational, and mental and physical health sequelae", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 12256, "first_name": "Kimberly A", "last_name": "Gray", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2016-09-30", "end_date": "2022-08-31", "award_amount": 161528, "principal_investigator": { "id": 21730, "first_name": "Brenda", "last_name": "Eskenazi", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1079, "ror": "", "name": "UNIVERSITY OF CALIFORNIA BERKELEY", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1079, "ror": "", "name": "UNIVERSITY OF CALIFORNIA BERKELEY", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "We have been engaged in the CHAMACOS study (R01ES026994, PI-Eskenazi), a longitudinal cohort study of more than 600 Latino primarily farmworker families (N=600 mother-child dyads, N=1200) in the agricultural Salinas Valley California for 20+ years. The overaching aim of this study has been to investigate the health sequelae of pesticide exposure over the lifecourse from in utero to adulthood. In this proposal, we aim to study the impact of the COVID-19 pandemic on these families. Low-income families, and particularly farmworker families, will likely be disproportionately infected by COVID-19 given cramped living quarters, their “essential” work status, traveling to work in crowded farmworker buses, and close working conditions on packing lines. In addition, substantial epidemiologic and toxicologic evidence suggests that pesticides, including organophosphates (OPs), organochlorines (OCs), carbamates, pyrethroids, the herbicide glyphosate, and ethylenebisdithiocarbamate (EBDC) fungicides can impact immunologic suppression and increase susceptibility to infectious diseases and more severe disease. For these reasons, we estimate that between 20%-40% of the CHAMACOS cohort will have been infected by January 2021. In addition, we hypothesize that the CHAMACOS cohort will be more impacted by the pandemic given poverty, insecure employment, risk for food scarcity, immigration status, and poor access to health services. For the 600 mother-child dyads, we have collected key information prior to the pandemic on health, financial and food security, and other relevant variables that may have been altered by the pandemic or increased risk of infection. The specific aims of this proposed supplement are to collect data post-COVID-19 to assess change in health (weight gain, increase in blood pressure, increase in anxiety or depression), food and housing security, access to medical care for COVID-19 or non-COVID-19 related conditions, fear of immigration authorities, barriers to protective behaviors during the pandemic (crowded housing, no indoor running water, workplace policies), and SARS-CoV-2 infection by serology. We will assess whether cumulative pesticide exposure increased risk for infection and disease. Pesticide exposure will be determined in two ways: by using California’s unique Pesticide Use Reporting data linked to 20-year residential history (the lifetime of the child) and using existing biomarkers of exposure (including prenatal and early life exposure of the child). To our knowledge, there is no other study of a similar population given the hard-to-reach nature of this cohort, the richness of the existing data, and our long-term relationship with the families and the community. Thus, our proposal will give a rare window into a population at high-risk of contracting COVID-19 and our unique opportunity to understand how the pandemic affects low-income Latino families who are living and working in a farmworker community is unsurpassed.", "keywords": [ "2019-nCoV", "Adult", "Adult Children", "Affect", "Agricultural Workers", "Agriculture", "Anxiety", "Area", "Back", "Behavior", "Biological Markers", "Blood Pressure", "COVID-19", "COVID-19 pandemic", "California", "Carbamates", "Caring", "Child", "Chlorinated Hydrocarbons", "Communicable Diseases", "Communities", "Contracts", "Crowding", "Data", "Data Reporting", "Disease", "Documentation", "Employment", "Epidemiology", "Exposure to", "Family", "Food", "Foundations", "Fright", "Funding", "Grant", "Health", "Health Benefit", "Health Knowledge Attitudes Practice", "Health Policy", "Health Services Accessibility", "Herbicides", "Home environment", "Housing", "Immigration", "Immune system", "Immunosuppression", "Individual", "Industrial fungicide", "Infection", "Knowledge", "Latino", "Link", "Longitudinal cohort study", "Low income", "Measures", "Medical", "Mental Depression", "Mental Health", "Mothers", "Muscle Cramp", "Nature", "Occupational Health", "Organophosphates", "Participant", "Personal Satisfaction", "Pesticides", "Policies", "Politics", "Population", "Positioning Attribute", "Poverty", "Predisposition", "Preventive", "Recommendation", "Recording of previous events", "Reporting", "Research", "Risk", "Running", "Salinas Valley", "Security", "Serologic tests", "Severity of illness", "Shelter facility", "Testing", "Toxicology", "Travel", "United States National Institutes of Health", "Universities", "Vulnerable Populations", "Water", "Weather", "Weight Gain", "Work", "Workplace", "agricultural community", "agricultural pesticide", "authority", "cohort", "community partnership", "conditioned fear", "coronavirus disease", "disorder risk", "early life exposure", "ethnic minority population", "farm worker", "food security", "glyphosate", "health assessment", "high risk", "immune health", "immunotoxicity", "in utero", "infection risk", "lower income families", "pandemic disease", "pesticide exposure", "physical conditioning", "prenatal", "protective behavior", "public health emergency", "pyrethroid", "rural America", "seropositive", "young adult" ], "approved": true } }, { "type": "Grant", "id": "7659", "attributes": { "award_id": "1ZIADK075135-05", "title": "Small Molecular Inactivators of HIV", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)" ], "program_reference_codes": [], "program_officials": [], "start_date": null, "end_date": null, "award_amount": 452638, "principal_investigator": { "id": 23463, "first_name": "daniel", "last_name": "appella", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1600, "ror": "https://ror.org/00adh9b73", "name": "National Institute of Diabetes and Digestive and Kidney Diseases", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1600, "ror": "https://ror.org/00adh9b73", "name": "National Institute of Diabetes and Digestive and Kidney Diseases", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "We have developed and studied our molecule both in the active form and as a prodrug. We have developed large-scale syntheses for these molecules and worked in collaboration to study their antiviral activity and evaluate their preclinical toxicity. Overall, the molecules show broad range of activity across a panel of HIV-1 clinical isolates in human PBMCs, demonstrate additive to synergistic antiviral interactions with other FDA-approved HIV drugs, and fail to allow the generation of HIV resistant strains after 14 passages. There is no observable toxicity with our molecules. Our molecules have also been successfully developed into platforms for application as a microbicide. We are currently examining the detailed mechanism of these molecules, performing an in vivo study, and exploring whether these molecules have antiviral activity against SARS-CoV-2.", "keywords": [ "2019-nCoV", "Acetyl Coenzyme A", "Acquired Immunodeficiency Syndrome", "Antiviral Agents", "Biological Testing", "Clinical", "Collaborations", "Drug resistance", "FDA approved", "Female", "Generations", "HIV", "HIV Infections", "HIV resistance", "HIV-1", "Human", "Lysine", "Molecular", "Peripheral Blood Mononuclear Cell", "Pharmaceutical Preparations", "Positioning Attribute", "Process", "Prodrugs", "Proteins", "Resistance development", "Toxic effect", "Translating", "Variant", "Viral", "Virus", "Virus Replication", "Work", "chemical synthesis", "in vivo", "male", "microbicide", "mortality", "preclinical toxicity", "prevent", "resistant strain", "scaffold", "transacylation", "transmission process" ], "approved": true } } ], "meta": { "pagination": { "page": 1383, "pages": 1424, "count": 14236 } } }