Represents Grant table in the DB

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        {
            "type": "Grant",
            "id": "15369",
            "attributes": {
                "award_id": "1R33DA061260-01",
                "title": "Efficacy and implementation considerations for a peer-led motivational interviewing intervention to promote uptake of drug checking services and safer drug use behaviors to reduce overdose",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
                "funder_divisions": [
                    "National Institute on Drug Abuse (NIDA)"
                ],
                "program_reference_codes": [],
                "program_officials": [
                    {
                        "id": 21283,
                        "first_name": "JULIA BETH",
                        "last_name": "Zur",
                        "orcid": null,
                        "emails": "",
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                        "keywords": null,
                        "approved": true,
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                ],
                "start_date": "2024-09-15",
                "end_date": "2029-05-31",
                "award_amount": 1042363,
                "principal_investigator": {
                    "id": 31969,
                    "first_name": "Annick",
                    "last_name": "Borquez",
                    "orcid": null,
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                "other_investigators": [
                    {
                        "id": 23320,
                        "first_name": "STEFFANIE A.",
                        "last_name": "STRATHDEE",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
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                            {
                                "id": 760,
                                "ror": "https://ror.org/0168r3w48",
                                "name": "University of California, San Diego",
                                "address": "",
                                "city": "",
                                "state": "CA",
                                "zip": "",
                                "country": "United States",
                                "approved": true
                            }
                        ]
                    }
                ],
                "awardee_organization": {
                    "id": 760,
                    "ror": "https://ror.org/0168r3w48",
                    "name": "University of California, San Diego",
                    "address": "",
                    "city": "",
                    "state": "CA",
                    "zip": "",
                    "country": "United States",
                    "approved": true
                },
                "abstract": "We will conduct a hybrid type 1 study to evaluate efficacy and preliminary implementation considerations for a novel intervention to promote uptake of drug checking services (DCS) and safer drug use behaviors among people who use drugs (PWUD) to reduce incidence of overdose (OD) in San Diego County. Along with ~50 other syringe services programs (SSPs) in the US, a local SSP recently began CheckSD, a DCS using test strips (TS) and Fourier Transform Infrared Spectrometry (FTIR) that allows people to submit drug samples with non-nominal identifiers and obtain personalized results. While CheckSD and most existing DCS with FTIR offer some counseling about DCS results, no theory-based interventions to increase DCS uptake and promote post- DCS adoption of safer drug use behaviors have been rigorously evaluated. We drew from the Social Ecological Model and Social Cognitive Theory (SCT) to develop and pilot MI-CHANCE (Motivational Interviewing for Community-based Harm reduction And drug-Checking Empowerment), a brief, bilingual, peer-led MI intervention. We culturally-tailored MI-CHANCE because Latinx PWUD are less likely to access harm reduction services, contributing to racial/ethnic disparities in OD rates. Our Aims are: Aim 1. To test the efficacy of MI- CHANCE on rates of combined fatal and non-fatal OD over 30 months and examine SCT-informed mediators and moderators of intervention effects (i.e., knowledge, outcome expectancies, self-efficacy). Aim 2. To conduct an inward-looking implementation evaluation to examine MI-CHANCE acceptability, feasibility and experiences among i) trial participants and ii) SSP staff in San Diego County; iii) collect data on implementation costs of MI-CHANCE and CheckSD to inform adoption by SSPs and policy-makers. Aim 3. To conduct an outward-looking exploration of MI-CHANCE's scalability among SSP staff at 20 other U.S. locations, purposively sampled to represent nascent and established DCS. To meet Aim 1, we will recruit 588 PWUD who have not yet used CheckSD into a two-arm RCT (N=294 per group). Both arms will have access to CheckSD's standard of care (SOC) already available at SSP sites (i.e., FTIR, and overdose education and naloxone distribution). PWUD randomized to receive MI-CHANCE will receive it from peer counselors trained in MI to encourage CheckSD uptake and safer drug use behaviors. Those in the attention-control SOC arm will receive COVID-19 education. All will undergo semi-annual follow-up for 30 months. Aims 2-3 will be guided by the revised RE-AIM/PRISM implementation science framework. This will be the first trial to rigorously evaluate efficacy and preliminary implementation of an intervention to optimize DCS uptake and behavioral outcomes for reducing OD. Despite the high promise of DCS, it is an innovation for which real world implementation is ahead of—but could be strengthened by—empirical research on behavioral intervention and implementation supports. If MI-CHANCE is efficacious, it could be rapidly deployed at harm reduction programs across the country to reduce OD deaths and disparities due to changes in the drug supply.",
                "keywords": [],
                "approved": true
            }
        },
        {
            "type": "Grant",
            "id": "8749",
            "attributes": {
                "award_id": "1U01IP001157-01",
                "title": "IP21-002, Enhanced Surveillance to Assess Vaccine Preventable Enteric and Respiratory Virus Illnesses",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
                "funder_divisions": [],
                "program_reference_codes": [],
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                "start_date": "2021-09-01",
                "end_date": "2026-08-31",
                "award_amount": 1441645,
                "principal_investigator": {
                    "id": 24541,
                    "first_name": "JANET A",
                    "last_name": "ENGLUND",
                    "orcid": null,
                    "emails": "",
                    "private_emails": "",
                    "keywords": null,
                    "approved": true,
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                    "affiliations": [
                        {
                            "id": 732,
                            "ror": "https://ror.org/01njes783",
                            "name": "Seattle Children's Hospital",
                            "address": "",
                            "city": "",
                            "state": "WA",
                            "zip": "",
                            "country": "United States",
                            "approved": true
                        }
                    ]
                },
                "other_investigators": [
                    {
                        "id": 24542,
                        "first_name": "Eileen",
                        "last_name": "Klein",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
                        "desired_collaboration": null,
                        "comments": null,
                        "affiliations": []
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                ],
                "awardee_organization": {
                    "id": 732,
                    "ror": "https://ror.org/01njes783",
                    "name": "Seattle Children's Hospital",
                    "address": "",
                    "city": "",
                    "state": "WA",
                    "zip": "",
                    "country": "United States",
                    "approved": true
                },
                "abstract": "We will conduct active, prospective inpatient, emergency department (ED) and asymptomatic healthy control (HC) surveillance in children at SCH and affiliated clinics in the Seattle metropolitan area. We will enroll subjects to describe the population-based burden of AGE and ARI in King County and Snohomish County, WA and evaluate effectiveness of licensed vaccines, such as influenza (Flu) and rotavirus (RV) vaccine (vx). We will assess the epidemiology and natural history of pediatric respiratory and enteric viral diseases and assess transmission dynamics for vx-preventable (RV, Flu) and potentially vx-preventable pathogens, such as norovirus (NV), respiratory syncytial virus (RSV), and SARS-CoV-2. After obtaining informed consent and assent, if applicable, in English or Spanish, we will interview families to collect epidemiological and clinical information, vaccine history, and obtain study specimens including respiratory and/or stool specimens, depending on clinical symptoms. Vaccination data are recorded in our state vaccine database, which is very reliable and complete. During times of COVID-19, novel methods of enrollment and capturing data may be utilized as per IRB- approved protocols including verbal or online consent, telephone interviews to complete data capture, and home specimen collection. Respiratory specimens and stool samples will be tested for multiple respiratory and enteric pathogens using sensitive and specific molecular PCR tests in laboratories using approved testing strategies that have been validated by proficiency testing. With this information, in addition to publicly available state-wide data describing inpatient and acute care visits in WA, we will obtain incidence rates of ED and inpatient visits and characterization of illness for multiple viral pathogens, including those responsible for vx- preventable disease and potentially vx-preventable disease, and others related to acute respiratory and enteric diseases, such as rhinovirus, EVD-68, parainfluenza viruses, adenoviruses, and human metapneumovirus. Additionally, we will continue ongoing surveillance for Acute Flaccid Myelitis (AFM) throughout WA state. In collaboration with statewide AFM expert and SCH neurologist, Dr. Catherine Otten and using WA DOH surveillance data we will conduct active surveillance, establish incidence rates, and compare rates of AFM to current circulation of respiratory and gastrointestinal infections. We will characterize the clinical spectrum of AFM by evaluating clinical and laboratory data, MRI findings, therapeutic interventions, and outcomes to inform early diagnosis, prognosis, prevention, and treatment.",
                "keywords": [],
                "approved": true
            }
        },
        {
            "type": "Grant",
            "id": "8923",
            "attributes": {
                "award_id": "1R01GM140316-01A1",
                "title": "Data Management for Molecule Simulation : A Throughput-Oriented Approach",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
                "funder_divisions": [
                    "National Institute of General Medical Sciences (NIGMS)"
                ],
                "program_reference_codes": [],
                "program_officials": [
                    {
                        "id": 7693,
                        "first_name": "Veerasamy",
                        "last_name": "Ravichandran",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
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                    }
                ],
                "start_date": "2021-09-22",
                "end_date": "2025-08-31",
                "award_amount": 287698,
                "principal_investigator": {
                    "id": 24748,
                    "first_name": "Yicheng",
                    "last_name": "Tu",
                    "orcid": null,
                    "emails": "",
                    "private_emails": "",
                    "keywords": null,
                    "approved": true,
                    "websites": null,
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                    "affiliations": [
                        {
                            "id": 235,
                            "ror": "https://ror.org/032db5x82",
                            "name": "University of South Florida",
                            "address": "",
                            "city": "",
                            "state": "FL",
                            "zip": "",
                            "country": "United States",
                            "approved": true
                        }
                    ]
                },
                "other_investigators": [],
                "awardee_organization": {
                    "id": 235,
                    "ror": "https://ror.org/032db5x82",
                    "name": "University of South Florida",
                    "address": "",
                    "city": "",
                    "state": "FL",
                    "zip": "",
                    "country": "United States",
                    "approved": true
                },
                "abstract": "We will design and develop a molecular simulation data management system, we call P2DMS, to analyze large dis- tributed molecular dynamics (MD) simulation data. The salient features of the system include: (1) a push-based local query engine design that handles data in a batch processing manner and processes many queries at the same time; (2) optimized MD analytics tools using modern many-core hardware such as GPUs; and (3) efficient management and access to distributed data over wide area networks, which is quite common for large scale MD simulations. This will be done by building a data analysis layer on top of state-of-the-art distributed big data management systems. The out- come of this project will not only improve the efficiency of MD data processing, but also enable new knowledge discov- ery that is currently regarded difficult or infeasible. In particular, we will integrate the P2DMS program into existing MD simulation packages, and validate the new design with important real-world biological and MD methodological prob- lems. In particular, we will (1) model the structure-function relationships of how the spike protein of SARS-CoV-2 inter- acts with the human angiotensin converting enzyme 2 (ACE2) receptor; and (2) enhance the performance of a recently developed parameter optimization software for active control of MD simulations.",
                "keywords": [
                    "ACE2",
                    "Algorithms",
                    "Biological",
                    "Biological Models",
                    "Biological Process",
                    "Biomimetic Materials",
                    "Collaborations",
                    "Communities",
                    "Computer Simulation",
                    "Computer software",
                    "Data",
                    "Data Analyses",
                    "Data Analytics",
                    "Data Management Resources",
                    "Data Set",
                    "Databases",
                    "Development",
                    "Distributed Systems",
                    "Docking",
                    "Genetic Diseases",
                    "Human",
                    "Individual",
                    "Knowledge Discovery",
                    "Letters",
                    "Location",
                    "Medical Research",
                    "Medicine",
                    "Methodology",
                    "Methods",
                    "Modeling",
                    "Modernization",
                    "Molecular",
                    "Motion",
                    "Names",
                    "Online Systems",
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                    "Pathology",
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                    "Pharmaceutical Preparations",
                    "Play",
                    "Process",
                    "Publishing",
                    "Research",
                    "Research Personnel",
                    "Resources",
                    "Role",
                    "SARS-CoV-2 infection",
                    "SARS-CoV-2 spike protein",
                    "Sampling",
                    "Stream",
                    "Structural Models",
                    "Structure",
                    "Structure-Activity Relationship",
                    "Supercomputing",
                    "System",
                    "Systems Analysis",
                    "Techniques",
                    "Testing",
                    "Thermodynamics",
                    "Time",
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                    "receptor",
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                    "simulation software",
                    "software systems",
                    "task analysis",
                    "tool",
                    "tool development",
                    "wide area network"
                ],
                "approved": true
            }
        },
        {
            "type": "Grant",
            "id": "9267",
            "attributes": {
                "award_id": "1U01CA261277-01",
                "title": "Casual, Statistical and Mathematical Modeling with Serologic Data",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
                "funder_divisions": [
                    "National Cancer Institute (NCI)"
                ],
                "program_reference_codes": [],
                "program_officials": [
                    {
                        "id": 25005,
                        "first_name": "Angela B",
                        "last_name": "Mariotto",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
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                    }
                ],
                "start_date": "2020-09-30",
                "end_date": "2022-08-31",
                "award_amount": 1695073,
                "principal_investigator": {
                    "id": 10507,
                    "first_name": "William",
                    "last_name": "Hanage",
                    "orcid": null,
                    "emails": "",
                    "private_emails": "",
                    "keywords": null,
                    "approved": true,
                    "websites": null,
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                    "affiliations": [
                        {
                            "id": 961,
                            "ror": "",
                            "name": "HARVARD SCHOOL OF PUBLIC HEALTH",
                            "address": "",
                            "city": "",
                            "state": "MA",
                            "zip": "",
                            "country": "United States",
                            "approved": true
                        }
                    ]
                },
                "other_investigators": [
                    {
                        "id": 25006,
                        "first_name": "MARC",
                        "last_name": "LIPSITCH",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
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                        "affiliations": []
                    }
                ],
                "awardee_organization": {
                    "id": 961,
                    "ror": "",
                    "name": "HARVARD SCHOOL OF PUBLIC HEALTH",
                    "address": "",
                    "city": "",
                    "state": "MA",
                    "zip": "",
                    "country": "United States",
                    "approved": true
                },
                "abstract": "We will develop methods to enhance the design and analysis of serologic studies of populations with respect to COVID-19, including methods that may be generalized in the future to address challenges raised by other seasonal diseases (such as influenza) and newly emerging diseases. In addition, we will use serologic data in innovative ways to underpin mathematical models that can project population-level trends. Early serosurveys using convenience samples of the population and serologic assays with variable and often uncertain sensitivity and specificity were heavily criticized, for unrepresentativeness and inadequate accounting for test characteristics, resulting in bias and overconfidence (unduly narrow confidence bounds). Aim 1 will develop methods for valid inference of seroprevalence, specifically by (a) accounting for biased sampling, (b) accounting for imperfect tests, and (c) developing and testing a novel approach to snowball sampling employing serologic tests to enhance outbreak detection and contact tracing. Valid comparisons that assess seroprotection—whether, how much, and how long an individual is protected by an immune response to a COVID-19 infection (specifically, by antibodies) against reinfection—rely on adequate control for confounding, an issue that arises in multiple ways specific to seroprotection studies. Likewise, waning of seroprotection may be inferred in error if studies are not carefully designed and analyzed. The unprecedented efforts to develop detailed serologic and systems serologic data sets provide new forms of data that can be leveraged to better inform these inferences. Aim 2 will develop a suite of methods to enhance causal inference in seroprotection studies, including (a) sample size and power calculations; and (b) improved exploitation of serological data to reduce biases due to confounding and risk compensation. Aim 3 will develop new mathematical modeling approaches and apply them to quantify the likely reduction in the herd immunity threshold for COVID-19 due to various forms of risk heterogeneity and assortativeness in mixing. Aim 4 will develop models of COVID-19 transmission that accommodate emerging evidence about the duration and nature of immunity to infection, shedding, and symptoms, to obtain estimates of how illness attack rates will differ under varying assumptions about the progress of immunity. Aim 5 will develop transmission models to assess optimal cohorting arrangements in congregate facilities (eg prisons and nursing homes), with special attention to the nature of immunity required for these arrangements to be beneficial. Finally, vaccine supplies may be initially limited, necessitating efficient use of them.  Aim 6 will investigate the use of serologic data in combination with other types of data to optimize allocation of scarce vaccines.",
                "keywords": [
                    "2019-nCoV",
                    "Address",
                    "Age",
                    "Attention",
                    "Biological Assay",
                    "COVID-19",
                    "Caregivers",
                    "Cessation of life",
                    "Communicable Diseases",
                    "Coronavirus",
                    "Data",
                    "Detection",
                    "Dose",
                    "Ethnic Origin",
                    "Goals",
                    "Herd Immunity",
                    "Human",
                    "Immunity",
                    "Immunoglobulin G",
                    "Individual",
                    "Infection",
                    "Infection prevention",
                    "Intervention",
                    "Lead",
                    "Longevity",
                    "Malignant Neoplasms",
                    "Mathematics",
                    "Modeling",
                    "Nature",
                    "Nursing Homes",
                    "Outcome",
                    "Persons",
                    "Population",
                    "Population Heterogeneity",
                    "Predisposition",
                    "Prevention",
                    "Prisons",
                    "Public Health",
                    "Race",
                    "Reporting",
                    "Risk Factors",
                    "Role",
                    "Scientific Advances and Accomplishments",
                    "Serology",
                    "Serology test",
                    "Seroprevalences",
                    "Severities",
                    "Signal Transduction",
                    "Structure",
                    "Symptoms",
                    "Time",
                    "Ursidae Family",
                    "Vaccination",
                    "Vaccines",
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                    "age group",
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                    "comorbidity",
                    "improved",
                    "infection risk",
                    "mathematical model",
                    "novel",
                    "pandemic disease",
                    "response",
                    "transmission process"
                ],
                "approved": true
            }
        },
        {
            "type": "Grant",
            "id": "11543",
            "attributes": {
                "award_id": "5R01AG075043-02",
                "title": "Long-Term Impact of the COVID-19 Pandemic on Self-Management of Chronic Conditions: The C3 Study",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
                "funder_divisions": [
                    "National Institute on Aging (NIA)"
                ],
                "program_reference_codes": [],
                "program_officials": [
                    {
                        "id": 20821,
                        "first_name": "JONATHAN W.",
                        "last_name": "KING",
                        "orcid": null,
                        "emails": "",
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                        "keywords": null,
                        "approved": true,
                        "websites": null,
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                    }
                ],
                "start_date": "2022-06-01",
                "end_date": "2027-03-31",
                "award_amount": 647329,
                "principal_investigator": {
                    "id": 23907,
                    "first_name": "Stacy C",
                    "last_name": "Bailey",
                    "orcid": null,
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                    "keywords": null,
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                    "affiliations": [
                        {
                            "id": 924,
                            "ror": "",
                            "name": "NORTHWESTERN UNIVERSITY AT CHICAGO",
                            "address": "",
                            "city": "",
                            "state": "IL",
                            "zip": "",
                            "country": "United States",
                            "approved": true
                        }
                    ]
                },
                "other_investigators": [
                    {
                        "id": 21022,
                        "first_name": "MICHAEL S",
                        "last_name": "WOLF",
                        "orcid": null,
                        "emails": "",
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                        "keywords": null,
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                            {
                                "id": 924,
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                                "name": "NORTHWESTERN UNIVERSITY AT CHICAGO",
                                "address": "",
                                "city": "",
                                "state": "IL",
                                "zip": "",
                                "country": "United States",
                                "approved": true
                            }
                        ]
                    },
                    {
                        "id": 23908,
                        "first_name": "Alex D",
                        "last_name": "Federman",
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                        "keywords": null,
                        "approved": true,
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                    }
                ],
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                    "id": 924,
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                    "name": "NORTHWESTERN UNIVERSITY AT CHICAGO",
                    "address": "",
                    "city": "",
                    "state": "IL",
                    "zip": "",
                    "country": "United States",
                    "approved": true
                },
                "abstract": "We will extend an active NIA cohort study of diverse, middle age and older adults with ≥1 chronic conditions to assess COVID-19’s long-term and disparate impact on health and healthcare experiences.  COVID-19 has become an unprecedented public health threat in modern times, especially for older adults with a chronic illness. As of January 2021, 94% of COVID deaths have been among adults over 55; 92% of those who have died had ≥1 underlying health conditions. Beyond consequences to personal health associated with acquiring COVID-19, the impact of the pandemic may likely extend to non-COVID-19 outcomes as a patient’s ability to self-manage chronic conditions during and after a pandemic may be compromised for several reasons.  In March 2020, our team rapidly launched the COVID-19 & Chronic Conditions (C3) study as cases of COVID-19 emerged in the U.S. to assess how adults with ≥1 chronic conditions were responding to the pandemic. Five active studies with uniform data collection on a range of patient-reported outcomes prior to COVID-19 and with electronic health records access were leveraged to establish the C3 cohort; 673 adults in Chicago were interviewed during the 1st week of the outbreak. The cohort was immediately expanded using two of the ‘parent studies’ that also had sites in New York City (n=200; N=873). C3 participants are diverse by socioeconomic status, race, ethnicity, gender, health literacy, and comorbidity. An NIA COVID-19 supplement was awarded in August 2020 to expand the cohort via the parent studies (N=1200) and continue data collection up to 2022; 5 of 7 planned survey waves have been completed (83-94% retention). C3 findings reveal many adults exhibit sustained, high stress due to COVID-19 that impacts lifestyle, treatment adherence, and healthcare use. Disparities by sex, race, ethnicity, and SES also are present. Health professionals and researchers are now voicing concern for possible long-term consequences of COVID-19 on personal health & healthcare.  In response, we propose to continue to follow the C3 cohort to capture data 5 years post onset of the U.S. outbreak. All participants will have a ‘Pre-COVID’ baseline and 7+ follow-up assessments to assess trajectories in health care use, patient-reported & chronic disease outcomes. Our primary aims are to: 1) evaluate changes in lifestyle, health behaviors, healthcare use, health status, and chronic disease outcomes from a pre-pandemic baseline through 5 years after onset of COVID-19; 2) determine the extent to which stress, anxiety, and depression contribute to poor health status and chronic disease outcomes through 5 years after the pandemic’s onset. Our secondary aim is to: 3) identify factors that mediate or moderate associations between stress, anxiety, and depression during/after the pandemic with health status and chronic disease outcomes, while our exploratory aim is to: 4) explore whether health disparities by age, sex, race, ethnicity, or socioeconomic status emerge or worsen during/after the pandemic and the contributing role of stress, anxiety, and depression.",
                "keywords": [
                    "Acute",
                    "Adherence",
                    "Adult",
                    "Affect",
                    "Age",
                    "Alcohols",
                    "Anxiety",
                    "Authorization documentation",
                    "Award",
                    "Biometry",
                    "COVID-19",
                    "COVID-19 impact",
                    "COVID-19 pandemic effects",
                    "COVID-19 stress",
                    "Caring",
                    "Cessation of life",
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                    "Chronic Disease",
                    "Cohort Studies",
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                    "Disease",
                    "Disease Outbreaks",
                    "Disease Outcome",
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                    "Infection prevention",
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                    "Long COVID",
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                    "Mental Depression",
                    "Mental Health",
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                    "New York City",
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                    "Parents",
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                    "Patient Outcomes Assessments",
                    "Patients",
                    "Personal Satisfaction",
                    "Persons",
                    "Physical activity",
                    "Policy Maker",
                    "Prevalence",
                    "Preventive Health Services",
                    "Psychosocial Assessment and Care",
                    "Public Health",
                    "Race",
                    "Recommendation",
                    "Reporting",
                    "Research Personnel",
                    "Risk Factors",
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                    "Self Efficacy",
                    "Self Management",
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                    "Sleep",
                    "Sleep disturbances",
                    "Social Distance",
                    "Social isolation",
                    "Social support",
                    "Socioeconomic Status",
                    "Stress",
                    "Surveys",
                    "Virus",
                    "Voice",
                    "Weight Gain",
                    "authority",
                    "cohort",
                    "comorbidity",
                    "coronavirus disease",
                    "experience",
                    "follow up assessment",
                    "functional status",
                    "health care service",
                    "health data",
                    "health disparity",
                    "health literacy",
                    "health management",
                    "long term consequences of COVID-19",
                    "middle age",
                    "novel",
                    "pandemic disease",
                    "pandemic impact",
                    "physical conditioning",
                    "physical inactivity",
                    "pre-pandemic",
                    "response",
                    "sex",
                    "sex disparity",
                    "socioeconomics",
                    "substance use",
                    "telehealth",
                    "treatment adherence"
                ],
                "approved": true
            }
        },
        {
            "type": "Grant",
            "id": "8001",
            "attributes": {
                "award_id": "1R01AG075043-01",
                "title": "Long-Term Impact of the COVID-19 Pandemic on Self-Management of Chronic Conditions: The C3 Study",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
                "funder_divisions": [
                    "National Institute on Aging (NIA)"
                ],
                "program_reference_codes": [],
                "program_officials": [
                    {
                        "id": 20821,
                        "first_name": "JONATHAN W.",
                        "last_name": "KING",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
                        "desired_collaboration": null,
                        "comments": null,
                        "affiliations": []
                    }
                ],
                "start_date": "2022-06-01",
                "end_date": "2027-03-31",
                "award_amount": 682908,
                "principal_investigator": {
                    "id": 23907,
                    "first_name": "Stacy C",
                    "last_name": "Bailey",
                    "orcid": null,
                    "emails": "",
                    "private_emails": "",
                    "keywords": null,
                    "approved": true,
                    "websites": null,
                    "desired_collaboration": null,
                    "comments": null,
                    "affiliations": [
                        {
                            "id": 924,
                            "ror": "",
                            "name": "NORTHWESTERN UNIVERSITY AT CHICAGO",
                            "address": "",
                            "city": "",
                            "state": "IL",
                            "zip": "",
                            "country": "United States",
                            "approved": true
                        }
                    ]
                },
                "other_investigators": [
                    {
                        "id": 21022,
                        "first_name": "MICHAEL S",
                        "last_name": "WOLF",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
                        "desired_collaboration": null,
                        "comments": null,
                        "affiliations": [
                            {
                                "id": 924,
                                "ror": "",
                                "name": "NORTHWESTERN UNIVERSITY AT CHICAGO",
                                "address": "",
                                "city": "",
                                "state": "IL",
                                "zip": "",
                                "country": "United States",
                                "approved": true
                            }
                        ]
                    },
                    {
                        "id": 23908,
                        "first_name": "Alex D",
                        "last_name": "Federman",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
                        "desired_collaboration": null,
                        "comments": null,
                        "affiliations": []
                    }
                ],
                "awardee_organization": {
                    "id": 924,
                    "ror": "",
                    "name": "NORTHWESTERN UNIVERSITY AT CHICAGO",
                    "address": "",
                    "city": "",
                    "state": "IL",
                    "zip": "",
                    "country": "United States",
                    "approved": true
                },
                "abstract": "We will extend an active NIA cohort study of diverse, middle age and older adults with ≥1 chronic conditions to assess COVID-19’s long-term and disparate impact on health and healthcare experiences.  COVID-19 has become an unprecedented public health threat in modern times, especially for older adults with a chronic illness. As of January 2021, 94% of COVID deaths have been among adults over 55; 92% of those who have died had ≥1 underlying health conditions. Beyond consequences to personal health associated with acquiring COVID-19, the impact of the pandemic may likely extend to non-COVID-19 outcomes as a patient’s ability to self-manage chronic conditions during and after a pandemic may be compromised for several reasons.  In March 2020, our team rapidly launched the COVID-19 & Chronic Conditions (C3) study as cases of COVID-19 emerged in the U.S. to assess how adults with ≥1 chronic conditions were responding to the pandemic. Five active studies with uniform data collection on a range of patient-reported outcomes prior to COVID-19 and with electronic health records access were leveraged to establish the C3 cohort; 673 adults in Chicago were interviewed during the 1st week of the outbreak. The cohort was immediately expanded using two of the ‘parent studies’ that also had sites in New York City (n=200; N=873). C3 participants are diverse by socioeconomic status, race, ethnicity, gender, health literacy, and comorbidity. An NIA COVID-19 supplement was awarded in August 2020 to expand the cohort via the parent studies (N=1200) and continue data collection up to 2022; 5 of 7 planned survey waves have been completed (83-94% retention). C3 findings reveal many adults exhibit sustained, high stress due to COVID-19 that impacts lifestyle, treatment adherence, and healthcare use. Disparities by sex, race, ethnicity, and SES also are present. Health professionals and researchers are now voicing concern for possible long-term consequences of COVID-19 on personal health & healthcare.  In response, we propose to continue to follow the C3 cohort to capture data 5 years post onset of the U.S. outbreak. All participants will have a ‘Pre-COVID’ baseline and 7+ follow-up assessments to assess trajectories in health care use, patient-reported & chronic disease outcomes. Our primary aims are to: 1) evaluate changes in lifestyle, health behaviors, healthcare use, health status, and chronic disease outcomes from a pre-pandemic baseline through 5 years after onset of COVID-19; 2) determine the extent to which stress, anxiety, and depression contribute to poor health status and chronic disease outcomes through 5 years after the pandemic’s onset. Our secondary aim is to: 3) identify factors that mediate or moderate associations between stress, anxiety, and depression during/after the pandemic with health status and chronic disease outcomes, while our exploratory aim is to: 4) explore whether health disparities by age, sex, race, ethnicity, or socioeconomic status emerge or worsen during/after the pandemic and the contributing role of stress, anxiety, and depression.",
                "keywords": [
                    "Acute",
                    "Adherence",
                    "Adult",
                    "Affect",
                    "Age",
                    "Alcohols",
                    "Anxiety",
                    "Award",
                    "Biometry",
                    "COVID-19",
                    "COVID-19 pandemic",
                    "Caring",
                    "Cessation of life",
                    "Chicago",
                    "Chronic",
                    "Chronic Disease",
                    "Cohort Studies",
                    "Collection",
                    "Communities",
                    "Data",
                    "Data Collection",
                    "Diet",
                    "Disease",
                    "Disease Outbreaks",
                    "Disease Outcome",
                    "Elderly",
                    "Electronic Health Record",
                    "Ethnic Origin",
                    "Exhibits",
                    "Fright",
                    "Gender",
                    "Grief reaction",
                    "Health",
                    "Health Professional",
                    "Health Status",
                    "Health behavior",
                    "Health system",
                    "Healthcare",
                    "Individual",
                    "Infection",
                    "Infection prevention",
                    "Intervention",
                    "Interview",
                    "Life Style",
                    "Long COVID",
                    "Mediating",
                    "Medical",
                    "Mental Depression",
                    "Mental Health",
                    "Modernization",
                    "Monitor",
                    "New York City",
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                    "Parents",
                    "Participant",
                    "Patient Outcomes Assessments",
                    "Patients",
                    "Personal Satisfaction",
                    "Persons",
                    "Physical activity",
                    "Prevalence",
                    "Preventive Health Services",
                    "Public Health",
                    "Race",
                    "Reporting",
                    "Research Personnel",
                    "Risk Factors",
                    "Role",
                    "Self Efficacy",
                    "Self Management",
                    "Site",
                    "Sleep",
                    "Sleep disturbances",
                    "Social Distance",
                    "Social isolation",
                    "Social support",
                    "Socioeconomic Status",
                    "Stress",
                    "Surveys",
                    "Time",
                    "Virus",
                    "Voice",
                    "Weight Gain",
                    "authority",
                    "cohort",
                    "comorbidity",
                    "coronavirus disease",
                    "experience",
                    "follow up assessment",
                    "functional status",
                    "health care service",
                    "health data",
                    "health disparity",
                    "health literacy",
                    "health management",
                    "long term consequences of COVID-19",
                    "middle age",
                    "novel",
                    "pandemic disease",
                    "physical conditioning",
                    "physical inactivity",
                    "psychosocial",
                    "response",
                    "sex",
                    "sex disparity",
                    "socioeconomics",
                    "substance use",
                    "telehealth",
                    "treatment adherence"
                ],
                "approved": true
            }
        },
        {
            "type": "Grant",
            "id": "5965",
            "attributes": {
                "award_id": "3P01AG027296-12S1",
                "title": "Alzheimer's Disease and Related Disorders Treatment and Outcomes in America: Changing Policies and Systems",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
                "funder_divisions": [
                    "National Institute on Aging (NIA)"
                ],
                "program_reference_codes": [],
                "program_officials": [
                    {
                        "id": 20420,
                        "first_name": "PARTHA",
                        "last_name": "BHATTACHARYYA",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
                        "desired_collaboration": null,
                        "comments": null,
                        "affiliations": []
                    }
                ],
                "start_date": "2007-09-15",
                "end_date": "2024-05-31",
                "award_amount": 270873,
                "principal_investigator": {
                    "id": 20421,
                    "first_name": "Vincent",
                    "last_name": "Mor",
                    "orcid": null,
                    "emails": "",
                    "private_emails": "",
                    "keywords": null,
                    "approved": true,
                    "websites": null,
                    "desired_collaboration": null,
                    "comments": null,
                    "affiliations": []
                },
                "other_investigators": [
                    {
                        "id": 20422,
                        "first_name": "AMAL N.",
                        "last_name": "TRIVEDI",
                        "orcid": null,
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
                        "desired_collaboration": null,
                        "comments": null,
                        "affiliations": []
                    }
                ],
                "awardee_organization": {
                    "id": 222,
                    "ror": "https://ror.org/05gq02987",
                    "name": "Brown University",
                    "address": "",
                    "city": "",
                    "state": "RI",
                    "zip": "",
                    "country": "United States",
                    "approved": true
                },
                "abstract": "We will illustrate how the COVID pandemic effected neuropsychiatric symptoms (NPS) and their management among nursing home (NH) residents with Alzheimer's Disease and Related Dementias (ADRD). NPS are frequent and difficult to manage under normal circumstances, and we hypothesize that COVID-prompted NH visitor restrictions and staffing reductions stimulated an increase in NPS and, consequently, in antipsychotic medication prescribing to manage NPS. The scientific premise of this proposal is that the COVID pandemic provides a unique opportunity to understand the dynamic between staffing, social isolation, NPS, and psychotropic medication use among NH residents with ADRD. The overall objective of this proposal is to measure the impact of COVID on resident behaviors and, in turn, the risk-benefit decisions to prescribe psychotropic medications in response. Our central hypothesis is that NH residents will have higher disruptions to daily care leading to more NPS and greater use of psychotropic medications during the COVID pandemic, especially within facilities with higher COVID infection rates. Our approach capitalizes on two data sources to establish trends in NPS and psychotropic use: national Minimum Data Set (MDS) assessments and electronic medical records (EMR) from a large NH chain with facilities in 30 states (Genesis Healthcare). Our aims are to: (1) evaluate changes in NPS among NH residents with ADRD during the COVID pandemic; (2) examine changes in psychotropic medication prescribing among NH residents with ADRD during the COVID pandemic; and (3) identify the proportion of NH residents with ADRD who remain long-term antipsychotic users during and post-COVID. The COVID pandemic has highlighted the tremendous needs of NH residents with ADRD. Ours will be the first large-scale investigation of factors that influence changes in NPS and psychotropic prescribing among NH residents with ADRD in the U.S. during COVID, identifying critical targets for future interventions and informing an evidence base for policy-making efforts to address future pandemics. This COVID-related supplement would extend the aims funded through Project 4 of P01AG027296, “Behavioral Control and Alzheimer's Disease: Policies, Medication Use, and Health Effects Across Care Settings.”",
                "keywords": [
                    "Address",
                    "Aggressive behavior",
                    "Agitation",
                    "Alzheimer&apos",
                    "s Disease",
                    "Alzheimer&apos",
                    "s disease related dementia",
                    "Americas",
                    "Antipsychotic Agents",
                    "Anxiety",
                    "Behavior",
                    "Behavior Control",
                    "Benefits and Risks",
                    "Biometry",
                    "COVID-19 pandemic",
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                    "Cessation of life",
                    "Communication",
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                    "Computerized Medical Record",
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                    "Critical Illness",
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                    "Drug Prescriptions",
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                    "Healthcare",
                    "Home Nursing Care",
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                    "Long-Term Care",
                    "Measures",
                    "Mental Depression",
                    "Nursing Homes",
                    "Patients",
                    "Persons",
                    "Pharmaceutical Preparations",
                    "Pharmacoepidemiology",
                    "Policies",
                    "Policy Making",
                    "Prevalence",
                    "Problem behavior",
                    "Psychoses",
                    "Quality of life",
                    "Quarantine",
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                    "Schedule",
                    "Social Interaction",
                    "Social isolation",
                    "Symptoms",
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                    "Treatment outcome",
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                    "coronavirus disease",
                    "evidence base",
                    "experience",
                    "falls",
                    "geriatric mental health",
                    "infection rate",
                    "neuropsychiatric symptom",
                    "off-label use",
                    "pandemic disease",
                    "reduce symptoms",
                    "response",
                    "stroke risk",
                    "transmission process",
                    "treatment strategy",
                    "trend"
                ],
                "approved": true
            }
        },
        {
            "type": "Grant",
            "id": "15927",
            "attributes": {
                "award_id": "1U01DA063078-01",
                "title": "A binational cohort of the intersection between substance use, HIV, and associated comorbidities among people who inject drugs in San Diego, CA",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
                "funder_divisions": [
                    "National Institute on Drug Abuse (NIDA)"
                ],
                "program_reference_codes": [],
                "program_officials": [
                    {
                        "id": 44370,
                        "first_name": "SHEBA KING",
                        "last_name": "DUNSTON",
                        "orcid": "",
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
                        "desired_collaboration": null,
                        "comments": null,
                        "affiliations": []
                    }
                ],
                "start_date": "2025-07-15",
                "end_date": "2030-05-31",
                "award_amount": 2437310,
                "principal_investigator": {
                    "id": 23320,
                    "first_name": "STEFFANIE A.",
                    "last_name": "STRATHDEE",
                    "orcid": null,
                    "emails": "",
                    "private_emails": "",
                    "keywords": null,
                    "approved": true,
                    "websites": null,
                    "desired_collaboration": null,
                    "comments": null,
                    "affiliations": [
                        {
                            "id": 760,
                            "ror": "https://ror.org/0168r3w48",
                            "name": "University of California, San Diego",
                            "address": "",
                            "city": "",
                            "state": "CA",
                            "zip": "",
                            "country": "United States",
                            "approved": true
                        }
                    ]
                },
                "other_investigators": [
                    {
                        "id": 44371,
                        "first_name": "Britt",
                        "last_name": "Skaathun",
                        "orcid": "",
                        "emails": "",
                        "private_emails": "",
                        "keywords": null,
                        "approved": true,
                        "websites": null,
                        "desired_collaboration": null,
                        "comments": null,
                        "affiliations": []
                    }
                ],
                "awardee_organization": {
                    "id": 2637,
                    "ror": "",
                    "name": "UNIVERSITY OF CALIFORNIA, SAN DIEGO",
                    "address": "",
                    "city": "",
                    "state": "CA",
                    "zip": "",
                    "country": "United States",
                    "approved": true
                },
                "abstract": "We will prospectively study the intersection between substance use, HIV and related co-morbidities in a cohort of people who use drugs (PWUD) in San Diego County (SD). For >25 years, Strathdee has studied the epidemiology of HIV and related co-infections among PWUD across North America, with N=500-1000 and annual retention ≥90%. Since 2020, our La Frontera I cohort situated on the U.S.-Mexico border has documented the highest HIV and HCV incidence among people who inject drugs in North America. Currently, HIV prevalence among former injectors in SD is 16% compared to 10% among current injectors. Consistent with other U.S. cities, we observed a dramatic shift from injection to non-injection of opiates in recent years, leading us to propose cohort expansion to non-injectors. Due to our location on a major drug trafficking corridor, we observe a wide range of substances (e.g., heroin, fentanyl, methamphetamine, xylazine, benzodiazepines). We previously leveraged La Frontera I to evaluate initiatives to improve uptake of PrEP, COVID-19 testing and vaccination. We propose: 1) To characterize trends and predictors of use of established and emerging drugs, drug use transitions (e.g., shifts from IDU to non-IDU & vice versa) and their impact on HIV incidence and utilization of HIV prevention and treatment. 2) To study prevalence and incidence of the following co-morbidities and their relationship to HIV incidence and utilization of HIV prevention and treatment: i) HCV; ii) STIs (i.e., syphilis, gonorrhea, Chlamydia, MPox), iii) neurobehavioral disturbances. 3) To evaluate the influence of structural interventions on HIV-related risk behaviors and utilization of HIV prevention and treatment including: i) new homelessness policies; ii) drug checking services; iii) vending machines. 4) To contribute to a shared database and biorepositories that serve as a platform for collaborations with end users and community partners. To meet these aims, we will continue to follow PWUD from La Frontera I who are actively using illicit substances, replenishing to arrive at 500 PWID and 500 PWUD (non-injectors) for a total sample of 1000. This will include subgroups vulnerable to HIV in SD (e.g., sex workers, people experiencing homelessness) among whom we expect 52 HIV seroconversions after 5 years of follow-up. Our cohort will include at least 50 PWUD living with HIV who will provide samples for viral load, sequencing and biobanking. All participants will undergo semi-annual interviews and specimen collection. SD is designated as a high priority jurisdiction for the Ending the HIV Epidemic Initiative (EHE) and a high intensity drug trafficking area by the DEA. La Frontera II leverages NIH-funded T32s, the California NeuroHIV Tissue Network, Last Gift Study brain/tissue repositories and the PREPARE Institute which tracks emerging and re-emerging infectious disease threats. Our work is aligned with priorities identified by RFA-DA-25-003, the NIH Office of AIDS Research and the EHE.",
                "keywords": [
                    "AIDS prevention",
                    "Area",
                    "Benzodiazepines",
                    "Biological",
                    "Border Crossings",
                    "Brain",
                    "COVID-19",
                    "COVID-19 testing",
                    "COVID-19 vaccination",
                    "California",
                    "Chlamydia",
                    "Cities",
                    "Collaborations",
                    "County",
                    "Coupled",
                    "Drug usage",
                    "Drug user",
                    "Emerging Communicable Diseases",
                    "Environmental Exposure",
                    "Epidemic",
                    "Epidemiology",
                    "Fentanyl",
                    "Functional disorder",
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                    "Gifts",
                    "Goals",
                    "Gonorrhea",
                    "HIV",
                    "HIV Seropositivity",
                    "HIV risk",
                    "HIV/HCV",
                    "Harm Reduction",
                    "Health",
                    "Hepatitis C Incidence",
                    "Hepatitis C virus",
                    "Heroin",
                    "Homelessness",
                    "Incidence",
                    "Infectious disease threat",
                    "Injecting drug user",
                    "Injections",
                    "Intervention",
                    "Interview",
                    "Lived experience",
                    "Location",
                    "Meta-Analysis",
                    "Methamphetamine",
                    "Mexico",
                    "Modeling",
                    "Molecular Epidemiology",
                    "Monkeypox",
                    "Mood Disorders",
                    "NIH Office of AIDS Research",
                    "National Institute of Drug Abuse",
                    "Needle Sharing",
                    "Neurocognitive",
                    "North America",
                    "Opioid",
                    "Participant",
                    "Pattern",
                    "Persons",
                    "Pharmaceutical Preparations",
                    "Policies",
                    "Positioning Attribute",
                    "Postdoctoral Fellow",
                    "Prevalence",
                    "Prevalence Study",
                    "Prospective Studies",
                    "Prospective cohort",
                    "Prospective  cohort study",
                    "Research",
                    "Research Priority",
                    "Risk Behaviors",
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                    "Sampling",
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                    "Statutes and Laws",
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                    "Syphilis",
                    "Testing",
                    "Tissue Banks",
                    "Tissues",
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                    "United States National Institutes of Health",
                    "Viral Load result",
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                ],
                "approved": true
            }
        },
        {
            "type": "Grant",
            "id": "7289",
            "attributes": {
                "award_id": "3R01AI036082-28S1",
                "title": "Neutralization of Primate Immunodeficiency Viruses",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
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                    "National Institute of Allergy and Infectious Diseases (NIAID)"
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                    {
                        "id": 8706,
                        "first_name": "Angela",
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                    }
                ],
                "start_date": "1994-05-01",
                "end_date": "2023-05-31",
                "award_amount": 177065,
                "principal_investigator": {
                    "id": 12701,
                    "first_name": "JOHN P",
                    "last_name": "MOORE",
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                    "emails": "",
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                        {
                            "id": 825,
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                            "name": "WEILL MEDICAL COLL OF CORNELL UNIV",
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                            "city": "",
                            "state": "NY",
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                            "country": "United States",
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                },
                "abstract": "We will repurpose existing assays, techniques and expertise that are central to our project team’s virology, structural biology, vaccine development and protein production skill-sets for HIV research, to now also work on SARS-CoV-2 during the COVID-19 pandemic emergency. These interactive research efforts will draw on our established methodologies and should represent a productive use of our existing NIH grant resources. We note that there continue to be institutional restrictions at all three performance sites on the effort that can be applied to our original goals relating to HIV-1 vaccine research and development. Those goals will be unchanged, but will be pursued at a reduced effort during the period when we also work on the new SARS-CoV-2 projects for which we have fewer institutional restrictions due to the COVID-19 pandemic.",
                "keywords": [
                    "2019-nCoV",
                    "Affinity Chromatography",
                    "Animals",
                    "Antigens",
                    "Biological Assay",
                    "COVID-19",
                    "COVID-19 pandemic",
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                    "Monoclonal Antibodies",
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                    "virology"
                ],
                "approved": true
            }
        },
        {
            "type": "Grant",
            "id": "8044",
            "attributes": {
                "award_id": "1R01MH123349-01A1",
                "title": "Social and structural violence and HIV care continuum outcomes: Developing a trauma-informed HIV care intervention among WLWH",
                "funder": {
                    "id": 4,
                    "ror": "https://ror.org/01cwqze88",
                    "name": "National Institutes of Health",
                    "approved": true
                },
                "funder_divisions": [
                    "National Institute of Mental Health (NIMH)"
                ],
                "program_reference_codes": [],
                "program_officials": [
                    {
                        "id": 12219,
                        "first_name": "Theresa Elaine",
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                        "approved": true,
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                ],
                "start_date": "2021-01-15",
                "end_date": "2025-11-30",
                "award_amount": 478234,
                "principal_investigator": {
                    "id": 23940,
                    "first_name": "Kathleen",
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                        {
                            "id": 1665,
                            "ror": "https://ror.org/03rmrcq20",
                            "name": "University of British Columbia",
                            "address": "",
                            "city": "",
                            "state": "BC",
                            "zip": "",
                            "country": "CANADA",
                            "approved": true
                        }
                    ]
                },
                "other_investigators": [
                    {
                        "id": 23941,
                        "first_name": "Kate",
                        "last_name": "Shannon",
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                        "approved": true,
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                ],
                "awardee_organization": {
                    "id": 1665,
                    "ror": "https://ror.org/03rmrcq20",
                    "name": "University of British Columbia",
                    "address": "",
                    "city": "",
                    "state": "BC",
                    "zip": "",
                    "country": "CANADA",
                    "approved": true
                },
                "abstract": "We will use innovative social epidemiological methods to longitudinally characterize the impacts and mechanisms of gender-based violence on the HIV care continuum, define key components of differentiated HIV care models that mitigate these relationships and develop a platform for trauma- and violence-informed HIV care and practice (TVI-HCP) interventions, among cisgender (cis) and transgender (trans) women living with HIV (WLWH). Emerging evidence suggests that the COVID-19 pandemic has resulted in heightened social and structural gender-based violence against cis and trans women, who are shouldering an inequitable share of the resulting impact of restrictions, physical distancing and economic downtown. Impacts felt by marginalized cis and trans women, including WLWH, are even more severe and the short- and long-term consequences in terms of trauma, violence, safety and HIV care continuum outcomes of cis and trans WLWH will need to be addressed. Even prior to COVID-19 crisis, despite substantial programmatic advancements, WLWH experienced gaps relative to cisgender men in all global HIV targets in many settings. Although the global prevalence of social and structural violence by WLWH is alarmingly high, there is a lack of research delineating mechanisms through which different types of violence impact HIV care continuum outcomes, to inform intervention targets. Moreover, despite calls to apply a trauma-and violence-informed care approach to HIV care and practice (TVI-HCP) and the unique needs of WLWH, surprisingly little is known about how this approach can be tailored in HIV clinical practice environments. In the proposed study we will leverage an existing community-based cohort of cis and trans WLWH in a Canadian setting (Sexual Health and HIV/AIDS: Women's Longitudinal Needs Assessment) and recapture and expand this cohort to 300 WLWH in the City of Vancouver. This quantitative study will include survey interviews, innovative mapping and spatial analyses, HIV disease monitoring, and confidential administrative linkages to fill critical research gaps and inform components of multi-level TVI-HCP programming to optimize HIV care continuum outcomes by: (1) Prospectively characterizing relationships between different types of violence experiences (interpersonal emotional, physical and sexual violence; neighbourhood violence) and viral load suppression failure and identifying critical mediators in these relationships on which to intervene; (2) Prospectively characterizing the key components of differentiated HIV care models that have the strongest associations with viral load suppression, expanding on our preliminary development and validation of a TVI-HCP Scale for WLWH; and (3) Establishing an innovative social epidemiological platform for informing and evaluating future multi-level trauma- and violence-informed HIV care interventions. Amidst the ongoing COVID-19 crisis, in parallel with a syndemic of violence, trauma and HIV in North America, our study offers an unprecedented opportunity to inform differentiated HIV care models to optimize HIV clinical outcomes among marginalized women.",
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                    "AIDS/HIV problem",
                    "Acquired Immunodeficiency Syndrome",
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                    "transgender",
                    "transgender women"
                ],
                "approved": true
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        "pagination": {
            "page": 1383,
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