Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1383&sort=-start_date
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-start_date", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1397&sort=-start_date", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=-start_date", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1382&sort=-start_date" }, "data": [ { "type": "Grant", "id": "6101", "attributes": { "award_id": "3U54MD007582-36S1", "title": "FAMU Center for Health Disparities Research", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 20761, "first_name": "Crystal", "last_name": "Barksdale", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-08-01", "end_date": "2024-02-29", "award_amount": 323255, "principal_investigator": { "id": 20762, "first_name": "KARAM F.A.", "last_name": "SOLIMAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 896, "ror": "", "name": "FLORIDA AGRICULTURAL AND MECHANICAL UNIV", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "The overall goal of this community partnership is to expose social determinants as well as behavioral, and ethical factors that may influence COVID-19 vaccination among racial, ethnic, and vulnerable community populations in Gadsden County, Florida. The County has among the country's highest shares of residents who are housed in nursing homes, prisons, or in other institutionalized group quarters (8.4%), and of households with no access to a vehicle (11.7%). Over the years, the College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health has developed strong collaborative relationships with community organizations in Gadsden County through various community-based participatory research projects. The study investigators have partnered with Gadsden County stakeholders and community-based organizations on several racial disparity issues such as infant mortality, cancer, diabetes, cardiovascular disease, and HIV/AIDS. As part of our community-based participatory approach, we will partner with the Gadsden Community Health Council to implement a quantitative survey to measure the perceptions of the community regarding the disparities in COVID-19 among racial/ethnic populations as well as intent to vaccinate against the virus. Additionally, qualitative interviews will be conducted with community members to better understand perceptions of vaccine hesitancy among vulnerable racial and ethnic populations. A behavioral intervention will be implemented utilizing CDC’s Community-Based Organizations COVID-19 Vaccine Toolkit and The Toolkit for Community and Faith-Based Organizations. Pre and Post intention to vaccinate will be based on the Theory of Planned Behavior.", "keywords": [ "AIDS/HIV problem", "African American", "Age", "Assisted Living Facilities", "Attitude", "Awareness", "Behavior", "Behavior Therapy", "Behavioral", "Belief", "Biological", "COVID-19", "COVID-19 outbreak", "COVID-19 pandemic", "COVID-19 vaccination", "COVID-19 vaccine", "Cardiovascular Diseases", "Censuses", "Centers for Disease Control and Prevention (U.S.)", "Cessation of life", "Communities", "Community Health", "Community based prevention", "Correctional Institutions", "Country", "County", "Data", "Depressed mood", "Diabetes Mellitus", "Discrimination", "Economically Deprived Population", "Education", "Ethics", "Ethnic group", "Exposure to", "Florida", "Goals", "Health", "Health behavior", "Hispanics", "Home", "Hospitals", "Household", "Human", "Individual", "Infant Mortality", "Institutes", "Institution", "Intention", "Intervention", "Interview", "Latino", "Malignant Neoplasms", "Measures", "Medical", "Medically Underserved Area", "Medicare/Medicaid", "Mental Health", "Minority Groups", "Modeling", "Not Hispanic or Latino", "Nursing Homes", "Obesity", "Outcome", "Participant", "Perception", "Persons", "Pharmacologic Substance", "Pharmacy facility", "Planning Theory", "Population", "Prisons", "Psychiatric Hospitals", "Public Health", "Quality of life", "Research", "Research Personnel", "Research Project Grants", "Resources", "Risk", "Science", "State Hospitals", "Surveys", "Target Populations", "Testing", "Time", "United States Health Resources and Services Administration", "Vaccinated", "Vaccines", "Virus", "Vulnerable Populations", "World Health Organization", "base", "college", "community based participatory research", "community organizations", "community partnership", "comorbidity", "disadvantaged population", "educationally disadvantaged", "experience", "health care availability", "health disparity", "health training", "high risk", "infection rate", "instrument", "interest", "member", "programs", "public health emergency", "racial and ethnic", "racial disparity", "racial population", "racism", "severe COVID-19", "social", "social determinants", "social group", "social structure", "vaccine acceptance", "vaccine distribution", "vaccine hesitancy" ], "approved": true } }, { "type": "Grant", "id": "6449", "attributes": { "award_id": "3P30CA069533-22S3", "title": "Understanding the impact on COVID-19 on health behaviors pertaining to cancer prevention, screening, and treatment activities and the mental health and well-being of cancer survivors", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 21659, "first_name": "Sonya", "last_name": "Roberson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-08-01", "end_date": "2022-06-30", "award_amount": 154000, "principal_investigator": { "id": 21660, "first_name": "BRIAN J", "last_name": "DRUKER", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 765, "ror": "https://ror.org/009avj582", "name": "Oregon Health & Science University", "address": "", "city": "", "state": "OR", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 765, "ror": "https://ror.org/009avj582", "name": "Oregon Health & Science University", "address": "", "city": "", "state": "OR", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic in the US and the world has had an impact both physical to psychological on individuals far beyond that of the acute illness. While resources and attention have rapidly and appropriately shifted to this current crisis, it is unclear how the virus and necessary community level responses to slow the spread of the virus have impacted ongoing needs for cancer prevention and screening activities as well as treatment and support for the particularly vulnerable cancer survivor population. Impacts of the pandemic may vary from simply delaying screening activities, to changed perceptions regarding cancer risk, to feelings of being disconnected from needed services, to disruption of treatment and suspension of social supports for cancer survivors. Our proposed research explores and quantifies the impact of COVID-19 and the necessary public health response to the crisis on cancer screening and risk behaviors among a random sample of individuals across our catchment area, as well as the unique and potentially more challenging effects on cancer survivors. An early understanding of these issues will allow us to be more effective in providing necessary novel supports to cancer survivors as well as identifying how to maintain screening and risk reducing behaviors both during the crisis and as we slowly return to a more normal state. Surveys, using constructs agreed upon by funded collaborating cancer centers and the NCI, assess psychosocial and behavioral impacts of COVID-19 on two target populations, a stratified probabilistic sample of households in Oregon and cancer patients and survivors from the Knight Cancer Institute residing in Oregon. Using an entirely app based data collection platform, the Healthy Oregon Project (HOP), surveys will be administered in a manner that allows for ease of participation from any location with cellular service, does not require in person contact, and is highly flexible allowing for the addition of surveys and opportunities for additional study contact rapidly and inexpensively. Differences in knowledge and attitudes about COVID-19, mitigation interventions related to the global pandemic, and its impact on mental health and well-being will are assessed through the application of multiple statistical approaches. Results from this research will inform a cancer center's understanding of the impacts of COVID-19 on cancer prevention and control and help guide development of education and communication strategies designed to effectively address specific challenges that were brought about by both the disease and our necessary social and public health response to the disease.", "keywords": [ "Acute", "Address", "Age", "Area", "Attention", "Attitude", "Behavior", "Behavioral", "COVID-19", "COVID-19 pandemic", "Cancer Center", "Cancer Control", "Cancer Patient", "Cancer Survivor", "Catchment Area", "Categories", "Chi-Square Tests", "Colonoscopy", "Communication", "Communities", "Data Collection", "Development", "Diet", "Disease", "Education", "Ethnic Origin", "Feeling", "Funding", "Gender", "Geography", "Health behavior", "Household", "Human Papilloma Virus Vaccine", "Individual", "Institutes", "Intervention", "Knowledge", "Location", "Logistic Regressions", "Malignant Neoplasms", "Mammography", "Measures", "Mental Health", "Oregon", "Outcome", "Pap smear", "Perception", "Personal Satisfaction", "Persons", "Physical activity", "Population", "Prevention", "Public Health", "Race", "Rank-Sum Tests", "Research", "Resources", "Risk", "Risk Behaviors", "Rural", "Safety", "Sampling", "Screening for cancer", "Services", "Social Distance", "Social support", "Surveys", "Suspensions", "Target Populations", "Time", "Tobacco use", "Uncertainty", "Virus", "Wilcoxon Rank Test", "base", "cancer prevention", "cancer risk", "data warehouse", "design", "flexibility", "novel", "novel coronavirus", "pandemic disease", "population based", "psychologic", "psychosocial", "response", "screening", "social", "sociodemographic factors", "urban area" ], "approved": true } }, { "type": "Grant", "id": "6557", "attributes": { "award_id": "3U54MD007582-37S1", "title": "FAMU Center for Health Disparities Research", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 21963, "first_name": "Crystal", "last_name": "Barksdale", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-08-01", "end_date": "2024-02-29", "award_amount": 292659, "principal_investigator": { "id": 21964, "first_name": "KARAM F.A.", "last_name": "SOLIMAN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 896, "ror": "", "name": "FLORIDA AGRICULTURAL AND MECHANICAL UNIV", "address": "", "city": "", "state": "FL", "zip": "", "country": "United States", "approved": true }, "abstract": "FAMU Center for Health Disparities Research OVERALL SUMMARY The overarching goal of the Florida A&M University (FAMU) RCMI Center application (2019-2024) is to establish an interdisciplinary Center to address minority health and health disparities while building on and enhancing the competitiveness of faculty-led health disparities research to attract extramural funding. Our Center for Health Disparities Research will enhance basic biomedical and behavioral research at FAMU while also improving upon investigator's research skills. To achieve the goal of the Center, we are proposing the following specific aims: 1) Enhance FAMU research capacity and rigor for basic biomedical/behavioral research pursuits by supporting innovative research projects, expanding research infrastructure, and strengthing community engagement partnership and activities that will create a sustainable research environment. 2) Increase the success rate of FAMU investigators in obtaining extramural research funding by enabling investigators to develop cutting- edge research competencies through the offering of Career Enhancement Program (CEP), the use of innovative technology, collaborations and use of resources provided by the RCMI Research Coordination network (RRCN). 3) Support new faculty and early career investigators in health disparities research by establishing an Investigator Development Core that will provide pilot projects funding and a robust mentoring program accompanied by a platform through the Career Enhancement Program. 4) Establish and support partnerships with the community to create a sustainable research environment that addresses health disparities research by establishing the RCMI Community Engagement Core (CEC) to promote early education awareness, detection, and screening. The center will also support three Innovative research projects in the areas of basic biomedical and behavioral addressing mechanisms, and screening intervention to reduce health disparities among minorities. These research projects will address novel therapy in breast cancer, validate innovative drug delivery for lung cancer and investigate new approaches to promoting colorectal cancer screening among minorities. Also, the Center will establish well-engaged collaborations and partnerships with recognized research centers and leverage the resources provided by NIH-supported programs such as the RCMI Research Coordination Network (RRCN) and NRMN. Achieving the goals of the Center will be greatly facilitated by the commitment and partnership of the Mayo Clinic Comprehensive Cancer Center- Jacksonville Florida, with its SPORE grants which will provide an environment that is conducive to career enhancement that would increase minority Junior Investigators' professional development and retention in cancer research. Also, the excellent opportunity of collaboration between the NCI U54 Funded Florida-California (CARE2) Health Equity Center and FAMU RCMI Center will provide many avenues to enhance and ensuring achieving the goals of the FAMU RCMI Center. The Center will have an external independent evaluator to implement an evaluation plan to reach data-driven decisions that will optimize the efficiency, effectiveness, and success of the center. The funding of this RCMI Center will enable FAMU achieving its mission of addressing health disparities through the enhancement of FAMU research capacity, increasing the number minority research investigators and promoting minority health and aid in the reduction of minority health disparities.", "keywords": [ "Address", "African American", "Area", "Awareness", "Behavioral", "Behavioral Research", "Biomedical Research", "California", "Clinic", "Collaborations", "Communities", "Competence", "Comprehensive Cancer Center", "Data", "Detection", "Development", "Doctor of Philosophy", "Drug Delivery Systems", "Education", "Effectiveness", "Ensure", "Environment", "Evaluation", "Extramural Activities", "Faculty", "Florida", "Funding", "Goals", "Grant", "Health Disparities Research", "Health Promotion", "Institution", "Interdisciplinary Study", "Intervention", "Investigator-Initiated Research", "Knowledge", "Malignant neoplasm of lung", "Mentors", "Minority", "Minority Groups", "Minority Health Research", "Mission", "Pharmacologic Substance", "Pilot Projects", "Public Health", "Reduce health disparities", "Research", "Research Infrastructure", "Research Personnel", "Research Project Grants", "Research Proposals", "Resources", "Science", "Scientific Inquiry", "Screening for cancer", "United States National Institutes of Health", "Universities", "Vision", "anticancer research", "base", "career", "colorectal cancer screening", "community engagement", "health disparity", "health equity", "improved", "innovation", "innovative technologies", "malignant breast neoplasm", "minority health", "novel strategies", "novel therapeutics", "programs", "screening", "skills", "success" ], "approved": true } }, { "type": "Grant", "id": "7424", "attributes": { "award_id": "3P30CA033572-37S2", "title": "A Phase 2 Trial of Leflunomide for the Treatment of COVID‐19 in Patients with Solid Tumors and Hematologic Malignancies", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 20549, "first_name": "Sonya", "last_name": "Roberson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-08-01", "end_date": "2022-11-30", "award_amount": 440000, "principal_investigator": { "id": 23218, "first_name": "STEVEN Terry", "last_name": "ROSEN", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1493, "ror": "", "name": "BECKMAN RESEARCH INSTITUTE/CITY OF HOPE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1493, "ror": "", "name": "BECKMAN RESEARCH INSTITUTE/CITY OF HOPE", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Novel interventions are urgently needed to address the COVID-19 pandemic, especially for highrisk populations. Leflunomide is a dihydroorotate dehydrogenase (DHODH) inhibitor, impacting pyrimidine synthesis for DNA and RNA production, and has been in use for over 20 years for treatment of autoimmune diseases such as rheumatoid arthritis and lupus with an excellent safety profile [1, 2]. It has known anti-viral activity and has been applied against cytomegalovirus (CMV) and polyoma BK virus infections in immunocompromised hosts [3, 4]. Leflunomide is orally available and exhibits hepatic clearance and a long elimination half-life. In vitro and in vivo experiments conducted in Wuhan, China demonstrated DHODH inhibitors have activity against COVID-19, including teriflunomide, the active metabolite of leflunomide [5]. Moreover, our preliminary data at City of Hope also suggest that leflunomide significantly arrests viral RNA replication in cancer cells infected with a naturally-occurring RNA virus (reovirus) and impairs ex vivo IL-6 expression in virally infected peripheral blood mononuclear cells (PBMCs).", "keywords": [ "Achievement", "Address", "Antiviral Agents", "Autoimmune Diseases", "BK Virus", "COVID-19", "COVID-19 pandemic", "Cancer Burden", "Cancer Patient", "Caring", "Characteristics", "China", "Cities", "City of Hope Comprehensive Cancer Center", "Clinical", "Clinical Investigator", "Collaborations", "Communities", "Cytomegalovirus", "DHODH gene", "DNA biosynthesis", "Data", "Development", "Diagnosis", "Dihydroorotate dehydrogenase", "Education", "Exhibits", "Fostering", "Goals", "Half-Life", "Hematologic Neoplasms", "Hepatic", "Immunocompromised Host", "Impairment", "In Vitro", "Individual", "Infrastructure", "Interleukin-6", "Intervention", "Investigation", "Leflunomide", "Link", "Lupus", "Malignant Neoplasms", "Methods", "Mission", "Oral", "Patient Care", "Patients", "Peripheral Blood Mononuclear Cell", "Polyomavirus", "Population", "Prevention", "Prevention strategy", "Production", "Pyrimidine", "RNA", "RNA Viruses", "RNA replication", "Reovirus", "Research", "Resource Sharing", "Rheumatoid Arthritis", "Safety", "Solid Neoplasm", "Speed", "Strategic Planning", "Viral", "Viral Physiology", "Virus Diseases", "cancer cell", "cancer rehabilitation", "experimental study", "first-in-human", "high risk", "in vivo", "inhibitor/antagonist", "innovation", "novel", "phase II trial", "population based", "survivorship", "viral RNA" ], "approved": true } }, { "type": "Grant", "id": "4942", "attributes": { "award_id": "3U54MD007602-35S1", "title": "Center for Translational Research in Health Disparities", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 17796, "first_name": "Priscah", "last_name": "Mujuru", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-07-07", "end_date": "2023-05-31", "award_amount": 353127, "principal_investigator": { "id": 17797, "first_name": "Vincent C", "last_name": "Bond", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 755, "ror": "https://ror.org/01pbhra64", "name": "Morehouse School of Medicine", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "The Morehouse School of Medicine (MSM) vision as detailed in our current Strategic Plan is “leading the creation and advancement of health equity”. To accomplish this vision, and ultimately health equity, new structures are required. More rapid translation of research discoveries has been facilitated through a “team-based approach” to address the health of the people and communities. This means bringing biomedical, clinical, and behavioral investigators and others together in Multidisciplinary Translational Teams (MDTT’s) focused on a health disparity that bring to bear their combined expertise to address populations health translating discoveries into practical solutions. MSM RCMI Program has been successful at developing research infrastructure including researchers. This application has been developed to bring the expertise of the RCMI Program Cores, with Community and Clinical researchers and partners to build Multidisciplinary Translational Teams across the T spectrum targeted at more rapid translation of health disparities (e.g., Cancer, Stroke, Infectious Diseases, Cardiometabolic Disease, Reproductive Health) by expanding the baseline research infrastructure established by Morehouse School of Medicine. The primary objectives are to build those teams through research projects targeted at health disparities, and to develop a pipeline of developing research teams at MSM, and to increase the level of involvement of investigators in conducting MDTT research at MSM. The U54 Center for Translational Research in Health Disparities (CTRHD) consists of five Cores (Administrative, Research Infrastructure, Investigation Development, Community Engagement, and Recruitment); Three Research Projects; an evaluation component attached to the Administrative Core, and a Pilot Project Program attached to the Investigator Development Core. With these assets and activities, the CTRHD will accomplish its goal through the following Aims: AIM 1: Transform Our Institution. Build processes and structures facilitating development of competitive multidisciplinary translational teams (MDTTs), allowing MSM to emerge as the preeminent, research-intensive, minority serving academic health center in the nation. AIM 2: Transform the MSM Research Environment. Develop collaborations allowing MSM faculty to do cutting edge translational health disparities research. AIM 3: Transform the Community of Scientists. Promote and accelerate training and mentoring capabilities at MSM, leading to the next generation of leaders in health disparities multidisciplinary translational research. AIM 4. Transform Our Community. Facilitate integration of Basic Research with Community Engagement.", "keywords": [ "Academy", "Address", "Basic Science", "Behavioral", "Bioinformatics", "Cardiometabolic Disease", "Center for Translational Science Activities", "Clinical", "Collaborations", "Communicable Diseases", "Communities", "Community Health", "Development", "Educational workshop", "Ensure", "Environment", "Evaluation", "Faculty", "Funding", "Goals", "Health", "Health Disparities Research", "Health Personnel", "Health Professional", "Individual", "Institution", "Interdisciplinary Communication", "Intervention", "Investigation", "Knowledge", "Malignant Neoplasms", "Mentors", "Minority", "Mission", "Modeling", "Monitor", "Morehouse School of Medicine", "Needles", "Patients", "Personal Satisfaction", "Persons", "Pilot Projects", "Policies", "Positioning Attribute", "Primary Health Care", "Process", "Public Health", "Reproductive Health", "Research", "Research Infrastructure", "Research Personnel", "Research Project Grants", "Research Support", "Resources", "Rural Population", "Scientist", "Services", "Strategic Planning", "Stroke", "Structure", "Technology", "Time", "Training", "Translating", "Translational Research", "Translations", "Urban Population", "Ursidae Family", "Vision", "Work", "base", "biomedical informatics", "clinical practice", "commercialization", "community based participatory research", "community engagement", "education research", "effectiveness evaluation", "health disparity", "health equity", "improved", "innovation", "learning strategy", "member", "minority health", "multidisciplinary", "next generation", "people of color", "population health", "programs", "recruit", "underserved community", "urban underserved" ], "approved": true } }, { "type": "Grant", "id": "5542", "attributes": { "award_id": "3U54MD007602-33S3", "title": "Center for Translational Research in Health Disparities", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 19246, "first_name": "Priscah", "last_name": "Mujuru", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-07-07", "end_date": "2023-05-31", "award_amount": 177500, "principal_investigator": { "id": 19247, "first_name": "Vincent C", "last_name": "Bond", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 755, "ror": "https://ror.org/01pbhra64", "name": "Morehouse School of Medicine", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "Abstract: Diversity in the rates of progression and mortality of COVID-19 disease within infected African American (AAs) subgroups are clearly not just a function of the underlying health conditions that increase the rate of mortality for COVID -19 patients, such as hypertension, obesity and diabetes, but may also be affected by host genetic factors. Here we propose a series of studies to advance the understanding of our knowledge in relative to the health inequity in COVID-19 disease. This is a multiple-collaborative study between Genomic, Imaging research labs and Statistical studies. Research teams in Morehouse School of Medicine (MSM) have established intimate relationships that position the institute to focus their research works on underserved minorities. We plan to develop and disseminate technological approaches in identifying host factors that disproportionately affect AAs COVID-19 infected patients. Given that the discovery, and establishment of translational implementation of novel solutions to health disparities in high-risk minority COVID-19 infected is our overall goals. Recently, angiotensin-converting enzyme 2 (ACE2), encoded on the X-chromosome, has been shown to be a functional receptor for COVID-19 to enter host target cells and the concern might arise regarding whether ACE2 variants between and within subgroups would increase the morbidity and mortality of COVID-19 infected patients. Therefore, the long-term goal is to compare how genetic variants of the ACE2 receptor, chemokine (CCL2) and human leukocyte antigen (HLA) genes (influence the immune system’s response to viruses and bacteria), affects COVID-19 disease severity among people but no underlining disease like diabetes, heart or lung disease with those with mild or no disease manifestations. Short-term goal; we will focus on two aims; Aim: 1-Determine genetic variations in ACE2 gene on obtained DNA samples from COVID-19 infected patients and evaluate for potential correlation between ACE2 variant frequencies in relationship to COVID-19 disease progression and mortalities between and within AAs and non-Hispanic Caucasian CAs subgroup;. COVID-19 is caused by SARS-CoV-2 which uses host cell ACE2, TMPRSS2, EZRIN and other proteins for entry. Differences in ACE2 or TMPRSS2/EZRIN genes expression and SNPs may justify the disease disparity and aim 2 will address how COVID-19 spike engagement with host cell receptor is precisely regulated and how host cells respond to cytokines elicited by COVID-19 infection using lung organoids. A recent correlation study suggested that the decrease expression of ACE2 /TMPRSS2/EZRIN are predictors of decreased susceptibility to COVID-19 infection and could be attributed to COVID-19 morbidity in Africa American patients. Aim-2: Modeling COVID-19-elicited disease disparity using lung organoids. Clinical validation of ACE2 and EZRIN will help to develop better strategies for COVID 19 diagnosis and treatment to reduce the observed COVID-19 disease progressive outcome and mortality gaps between African American and Caucasians patients. .", "keywords": [ "2019-nCoV", "ACE2", "Address", "Affect", "Africa", "African American", "American", "Bacteria", "Biology", "Blood specimen", "CCL2 gene", "COVID-19", "COVID-19 diagnosis", "COVID-19 morbidity", "COVID-19 mortality", "COVID-19 patient", "COVID-19 severity", "COVID-19 treatment", "Caucasians", "Cells", "Center for Translational Science Activities", "Clinical", "Correlation Studies", "DNA", "Data", "Diabetes Mellitus", "Disease", "Disease Progression", "Female", "Frequencies", "Gene Expression", "Genes", "Genetic", "Genetic Predisposition to Disease", "Genetic Variation", "Genomics", "Goals", "HLA Antigens", "Health", "Heart Diseases", "Hospitals", "Hypertension", "Image", "Immune response", "Incidence", "Individual", "Institutes", "Integration Host Factors", "Knowledge", "Lung", "Lung diseases", "Minority", "Modeling", "Molecular", "Morbidity - disease rate", "Morehouse School of Medicine", "Not Hispanic or Latino", "Obesity", "Organoids", "Outcome", "Patients", "Peripheral Blood Mononuclear Cell", "Play", "Population", "Positioning Attribute", "Predisposition", "Progressive Disease", "Proteins", "Receptor Cell", "Research", "Risk", "Role", "SARS-CoV-2 infection", "Sampling", "Series", "Socioeconomic Factors", "Statistical Study", "Subgroup", "TMPRSS2 gene", "Testing", "Validation", "Variant", "Virus", "Work", "X Chromosome", "chemokine", "comorbidity", "cytokine", "differential expression", "disease disparity", "ezrin", "genetic variant", "health disparity", "health inequalities", "high risk", "machine learning algorithm", "male", "mortality", "novel", "outcome prediction", "predictive modeling", "racial disparity", "receptor", "transcriptome sequencing", "underserved minority" ], "approved": true } }, { "type": "Grant", "id": "5543", "attributes": { "award_id": "3U54MD007602-34S3", "title": "Center for Translational Research in Health Disparities- RCMI Supplement Young Adult (18-24) Community Mental Health WorkersVaccine Hesitancy, Uptake and Community Engagement", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 19248, "first_name": "Priscah", "last_name": "Mujuru", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-07-07", "end_date": "2023-05-31", "award_amount": 353127, "principal_investigator": { "id": 19249, "first_name": "Vincent C", "last_name": "Bond", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 755, "ror": "https://ror.org/01pbhra64", "name": "Morehouse School of Medicine", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "The Morehouse School of Medicine (MSM) vision as detailed in our current Strategic Plan is “leading the creation and advancement of health equity”. To accomplish this vision, and ultimately health equity, new structures are required. More rapid translation of research discoveries has been facilitated through a “team-based approach” to address the health of the people and communities. This means bringing biomedical, clinical, and behavioral investigators and others together in Multidisciplinary Translational Teams (MDTT’s) focused on a health disparity that bring to bear their combined expertise to address populations health translating discoveries into practical solutions. MSM RCMI Program has been successful at developing research infrastructure including researchers. This application has been developed to bring the expertise of the RCMI Program Cores, with Community and Clinical researchers and partners to build Multidisciplinary Translational Teams across the T spectrum targeted at more rapid translation of health disparities (e.g., Cancer, Stroke, Infectious Diseases, Cardiometabolic Disease, Reproductive Health) by expanding the baseline research infrastructure established by Morehouse School of Medicine. The primary objectives are to build those teams through research projects targeted at health disparities, and to develop a pipeline of developing research teams at MSM, and to increase the level of involvement of investigators in conducting MDTT research at MSM. The U54 Center for Translational Research in Health Disparities (CTRHD) consists of five Cores (Administrative, Research Infrastructure, Investigation Development, Community Engagement, and Recruitment); Three Research Projects; an evaluation component attached to the Administrative Core, and a Pilot Project Program attached to the Investigator Development Core. With these assets and activities, the CTRHD will accomplish its goal through the following Aims: AIM 1: Transform Our Institution. Build processes and structures facilitating development of competitive multidisciplinary translational teams (MDTTs), allowing MSM to emerge as the preeminent, research-intensive, minority serving academic health center in the nation. AIM 2: Transform the MSM Research Environment. Develop collaborations allowing MSM faculty to do cutting edge translational health disparities research. AIM 3: Transform the Community of Scientists. Promote and accelerate training and mentoring capabilities at MSM, leading to the next generation of leaders in health disparities multidisciplinary translational research. AIM 4. Transform Our Community. Facilitate integration of Basic Research with Community Engagement. Supplement In an effort to examine and decrease COVID-19 vaccination hesitancy among the Haitian American immigrant population, and to decrease mental health disparities among underserved youth, our team proposes to culturally adapt, implement, and conduct a preliminary validation of a youth (18-24) led health and mental health education campaign to address COVID-19 related psychosocial stressors. Our central hypothesis is that through participation in this program, young adults become active agents in the development of positive health outcomes for themselves, their families, and community. Participation in HSYACHW will encourage healthy behaviors and better health outcomes, while helping to mitigate the adverse emotional effects of COVID-19 and vaccine hesitancy among underserved young adults. Our objective is to utilize social ecological public health theory and Community-based Participatory approach to examine the sociodemographic factors involved in motivating young adults to develop strategies for influencing health outcomes at the individual, family, and community levels. This work also aims to foster the development and sustainability of positive health behaviors among medically underserved youth, their families and communities. This is a RCMI Supplemental project is to adapt and evaluate this approach. The specific aims are: 1) To adapt the High School & Young Adult Community Health Worker Training program for use with young adult refugee and Immigrant populations (ages 18-24) of Haitian descent; 2) To implement and validate the success of the adapted HSYACHW within the target population to vaccine hesitancy and uptake and improved mental health.", "keywords": [ "Academy", "Address", "Adolescent", "Adult", "Age", "American", "Awareness", "Basic Science", "Behavior", "Behavioral", "COVID-19", "COVID-19 vaccination", "COVID-19 vaccine", "Cardiometabolic Disease", "Center for Translational Science Activities", "Child", "Childhood", "Clinical", "Collaborations", "Communicable Diseases", "Communication", "Communities", "Community Health", "Community Health Aides", "Contact Tracing", "Contracts", "Critical Thinking", "Development", "Educational Curriculum", "Emotional", "Environment", "Evaluation", "Exercise", "Faculty", "Family", "Focus Groups", "Fostering", "Funding", "Goals", "Haitian", "Health", "Health Promotion", "Health Status", "Health behavior", "Healthy Eating", "Immigrant", "Individual", "Institution", "Instruction", "Intervention", "Investigation", "Journals", "Knowledge", "Link", "Malignant Neoplasms", "Measures", "Medicine", "Mental Health", "Mentors", "Minority", "Morbidity - disease rate", "Morehouse School of Medicine", "New York", "Nurses", "Nutritional", "Outcome", "Participant", "Pathway interactions", "Pilot Projects", "Policies", "Population", "Principal Investigator", "Process", "Psychologist", "Public Health", "Public Health Education", "Recording of previous events", "Refugees", "Reproductive Health", "Research", "Research Infrastructure", "Research Personnel", "Research Project Grants", "Research Proposals", "Resources", "Risk", "Schools", "Scientist", "Source", "Strategic Planning", "Stroke", "Structure", "Students", "Target Populations", "Training", "Training Programs", "Translating", "Translational Research", "Translations", "Trust", "Urban Health", "Ursidae Family", "Vaccination", "Validation", "Virus", "Vision", "Work", "Youth", "adolescent health", "base", "combat", "community engagement", "design", "disorder prevention", "empowerment", "experience", "health disparity", "health disparity populations", "health equity", "health literacy", "high school", "improved", "innovation", "intervention effect", "medically underserved", "medically underserved population", "member", "men", "mental health education", "mortality", "multidisciplinary", "news", "next generation", "online course", "population health", "preventive intervention", "programs", "psychologic", "psychosocial", "psychosocial stressors", "public health intervention", "recruit", "research and development", "satisfaction", "social", "social norm", "sociodemographic factors" ], "approved": true } }, { "type": "Grant", "id": "6709", "attributes": { "award_id": "5U54MD007602-35", "title": "Community Engagement Core", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 22451, "first_name": "Priscah", "last_name": "Mujuru", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-07-07", "end_date": "2023-05-31", "award_amount": 329038, "principal_investigator": { "id": 22452, "first_name": "RONALD Lloyd", "last_name": "BRAITHWAITE", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 755, "ror": "https://ror.org/01pbhra64", "name": "Morehouse School of Medicine", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 755, "ror": "https://ror.org/01pbhra64", "name": "Morehouse School of Medicine", "address": "", "city": "", "state": "GA", "zip": "", "country": "United States", "approved": true }, "abstract": "The Morehouse School of Medicine (MSM) vision as detailed in our current Strategic Plan is “leading the creation and advancement of health equity”. To accomplish this vision, and ultimately health equity, new structures are required. More rapid translation of research discoveries has been facilitated through a “team-based approach” to address the health of the people and communities. This means bringing biomedical, clinical, and behavioral investigators and others together in Multidisciplinary Translational Teams (MDTT’s) focused on a health disparity that bring to bear their combined expertise to address populations health translating discoveries into practical solutions. MSM RCMI Program has been successful at developing research infrastructure including researchers. This application has been developed to bring the expertise of the RCMI Program Cores, with Community and Clinical researchers and partners to build Multidisciplinary Translational Teams across the T spectrum targeted at more rapid translation of health disparities (e.g., Cancer, Stroke, Infectious Diseases, Cardiometabolic Disease, Reproductive Health) by expanding the baseline research infrastructure established by Morehouse School of Medicine. The primary objectives are to build those teams through research projects targeted at health disparities, and to develop a pipeline of developing research teams at MSM, and to increase the level of involvement of investigators in conducting MDTT research at MSM. The U54 Center for Translational Research in Health Disparities (CTRHD) consists of five Cores (Administrative, Research Infrastructure, Investigation Development, Community Engagement, and Recruitment); Three Research Projects; an evaluation component attached to the Administrative Core, and a Pilot Project Program attached to the Investigator Development Core. With these assets and activities, the CTRHD will accomplish its goal through the following Aims: AIM 1: Transform Our Institution. Build processes and structures facilitating development of competitive multidisciplinary translational teams (MDTTs), allowing MSM to emerge as the preeminent, research-intensive, minority serving academic health center in the nation. AIM 2: Transform the MSM Research Environment. Develop collaborations allowing MSM faculty to do cutting edge translational health disparities research. AIM 3: Transform the Community of Scientists. Promote and accelerate training and mentoring capabilities at MSM, leading to the next generation of leaders in health disparities multidisciplinary translational research. AIM 4. Transform Our Community. Facilitate integration of Basic Research with Community Engagement. Supplement In an effort to examine and decrease COVID-19 vaccination hesitancy among the Haitian American immigrant population, and to decrease mental health disparities among underserved youth, our team proposes to culturally adapt, implement, and conduct a preliminary validation of a youth (18-24) led health and mental health education campaign to address COVID-19 related psychosocial stressors. Our central hypothesis is that through participation in this program, young adults become active agents in the development of positive health outcomes for themselves, their families, and community. Participation in HSYACHW will encourage healthy behaviors and better health outcomes, while helping to mitigate the adverse emotional effects of COVID-19 and vaccine hesitancy among underserved young adults. Our objective is to utilize social ecological public health theory and Community-based Participatory approach to examine the sociodemographic factors involved in motivating young adults to develop strategies for influencing health outcomes at the individual, family, and community levels. This work also aims to foster the development and sustainability of positive health behaviors among medically underserved youth, their families and communities. This is a RCMI Supplemental project is to adapt and evaluate this approach. The specific aims are: 1) To adapt the High School & Young Adult Community Health Worker Training program for use with young adult refugee and Immigrant populations (ages 18-24) of Haitian descent; 2) To implement and validate the success of the adapted HSYACHW within the target population to vaccine hesitancy and uptake and improved mental health.", "keywords": [ "Academy", "Address", "Adolescent", "Adult", "Age", "American", "Awareness", "Basic Science", "Behavior", "Behavioral", "COVID-19", "COVID-19 vaccination", "COVID-19 vaccine", "Cardiometabolic Disease", "Center for Translational Science Activities", "Child", "Childhood", "Clinical", "Collaborations", "Communicable Diseases", "Communication", "Communities", "Community Health", "Community Health Aides", "Contact Tracing", "Contracts", "Critical Thinking", "Development", "Educational Curriculum", "Emotional", "Environment", "Evaluation", "Exercise", "Faculty", "Family", "Focus Groups", "Fostering", "Funding", "Goals", "Haitian", "Health", "Health Disparities Research", "Health Promotion", "Health Status", "Health behavior", "Healthy Eating", "Immigrant", "Individual", "Institution", "Instruction", "Intervention", "Investigation", "Journals", "Knowledge", "Link", "Malignant Neoplasms", "Measures", "Medicine", "Mental Health", "Mentors", "Minority", "Morbidity - disease rate", "Morehouse School of Medicine", "New York", "Nurses", "Nutritional", "Outcome", "Participant", "Pathway interactions", "Persons", "Pilot Projects", "Policies", "Population", "Principal Investigator", "Process", "Psychologist", "Public Health", "Public Health Education", "Recording of previous events", "Refugees", "Reproductive Health", "Research", "Research Infrastructure", "Research Personnel", "Research Project Grants", "Research Proposals", "Resources", "Risk", "Schools", "Scientist", "Source", "Strategic Planning", "Stroke", "Structure", "Students", "Target Populations", "Training", "Training Programs", "Translating", "Translational Research", "Translations", "Trust", "Urban Health", "Ursidae Family", "Vaccination", "Validation", "Virus", "Vision", "Work", "Youth", "adolescent health", "base", "combat", "community engagement", "design", "disorder prevention", "empowerment", "experience", "health disparity", "health disparity populations", "health equity", "health literacy", "high school", "improved", "innovation", "intervention effect", "long term consequences of COVID-19", "medically underserved", "medically underserved population", "member", "men", "mental health education", "mortality", "multidisciplinary", "news", "next generation", "online course", "population health", "preventive intervention", "process evaluation", "programs", "psychologic", "psychosocial", "psychosocial stressors", "public health intervention" ], "approved": true } }, { "type": "Grant", "id": "6982", "attributes": { "award_id": "3U54MD007585-30S1", "title": "Promoting the Desire to participate in Covid-19 Vaccination among Underserved Rural and Minority Communities in Alabama: The WeCARE proposal.", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [ { "id": 8046, "first_name": "Nathaniel", "last_name": "Stinson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-07-07", "end_date": "2023-08-31", "award_amount": 242550, "principal_investigator": { "id": 21075, "first_name": "Clayton", "last_name": "Yates", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 569, "ror": "https://ror.org/0137n4m74", "name": "Tuskegee University", "address": "", "city": "", "state": "AL", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 569, "ror": "https://ror.org/0137n4m74", "name": "Tuskegee University", "address": "", "city": "", "state": "AL", "zip": "", "country": "United States", "approved": true }, "abstract": "The overall objective of the Tuskegee University Center for Biomedical Research/Research Centers in Minority Institutions (TU CBR/RCMI) Program is to build upon and develop the University’s research infrastructure and researchers to conduct research related to health disparities. This initiative is centered around: 1) providing the necessary infrastructure, resources, services, and technical support to enhance the ability of the University’s researchers to stay on the cutting-edge of multidisciplinary biomedical research focused on health disparities and 2) supporting the research and career development of junior- and mid-level investigators. These objectives are to be achieved primarily through the following aims: 1) Provide pilot-level funding to support the development and expansion of the biomedical research capacity of TU; 2) Provide core research facilities equipped with the infrastructure, instrumentation, and personnel to support the needs of the TU research community; 3) Engage the community through RCMI-sponsored activities that include the research faculty; and 4) Provide mentorship and career guidance to enhance the transition of junior-level investigators into independent scientists. The overall goal of the CBR/RCMI project (2017-2022) is to continue the development of its infrastructure and increase the numbers and skill proficiency of minority scientists engaged in advanced biomedical research focused on health disparities, including those for HIV, obesity, and prostate cancer, all of which disproportionately affect African Americans and underrepresented minorities. In other words, the goal is to continue support for a competitive, multidisciplinary collaborative environment that advances biomedical research. Tuskegee University has distinctive strengths because it is located in the heart of the Southeast, a region with a large, historically underserved, African American population, and it has a large number of minority faculty members as well as undergraduate and graduate trainees. The goal of the CBR/RCMI will be accomplished through establishment of three synergistic research cores, with services to enable investigative research on health inequities among minority groups, especially African-Americans residing in the ‘Black Belt’ counties of Alabama. These cores create a stimulating environment that promotes a culture of efficient and timely administrative support that will increase the number of funding submissions and/or acquisitions of extramural funding in biomedical and community engagement research. The Administrative Core will provide multi-functional support through pre- and post-award services; implementation of objectives, directions, and guidance; and oversight to ensure that specific aims and objectives are accomplished. Additionally, the Investigator Development Core will support the development of additional areas of research while enhancing the growth of junior faculty through senior mentorship and bioethics training. Further, through our community engagement core, we will establish relationships, build trust, and engage local communities and community-based organizations to learn from and to educate community members on health issues that affect them. We will also implement an evaluation plan to assess, over a period of five years, the progress, productivity, and accountability of the CBR by using both formative and summative outcomes. The outcome is to increase, by an approved and enforceable protocol that focuses on junior faculty development and productivity, the number of R-type grants awarded and the number of publications in peer- reviewed journals. The availability of advanced research equipment, coupled with the new knowledge generated by TU PhD students, scientists, and collaborators will contribute to the reduction of health disparities in the Black Belt counties of Alabama.", "keywords": [ "Accountability", "Address", "Affect", "African American", "Alabama", "Applications Grants", "Area", "Award", "Behavioral Research", "Bioethics", "Bioinformatics", "Biomedical Research", "Biometry", "COVID-19 vaccination", "Collaborations", "Communities", "Community Outreach", "Computational Biology", "Core Facility", "County", "Coupled", "Deep South", "Development", "Doctor of Philosophy", "Education", "Educational process of instructing", "Educational workshop", "Ensure", "Environment", "Equipment", "Evaluation", "Exercise", "Extramural Activities", "Faculty", "Fostering", "Foundations", "Funding", "Goals", "Government", "Grant", "Growth", "HIV", "Health", "Heart", "Human Resources", "Infrastructure", "Institution", "Journals", "Knowledge", "Learning", "Location", "Malignant Neoplasms", "Malignant neoplasm of prostate", "Maps", "Mentors", "Mentorship", "Minority", "Minority Groups", "Minority-Serving Institution", "Mission", "Molecular", "Obesity", "Outcome", "Peer Review", "Population", "Positioning Attribute", "Productivity", "Protocols documentation", "Publications", "Research", "Research Infrastructure", "Research Personnel", "Research Project Grants", "Research Support", "Resources", "Rural Community", "STEM career", "Science", "Science Technology Engineering and Mathematics Education", "Scientist", "Services", "Solid", "Teacher Professional Development", "Time", "Training", "Trust", "Underrepresented Minority", "Underrepresented Populations", "Underserved Population", "Universities", "Vocational Guidance", "Work", "base", "biological research", "career", "career development", "collaborative environment", "community based research", "community engagement", "design", "doctoral student", "ethnic minority population", "experience", "faculty research", "health disparity", "health inequalities", "instrumentation", "inter-institutional", "interest", "learning community", "member", "minority communities", "minority health", "minority scientist", "minority student", "multidisciplinary", "outreach services", "programs", "racial health disparity", "research and development", "research facility", "rural underserved", "skills", "undergraduate student" ], "approved": true } }, { "type": "Grant", "id": "7094", "attributes": { "award_id": "3P30CA016056-43S3", "title": "Phase IbTrial of Rintatolimod and IFNa Regimen in Cancer Patients with Mild or Moderate COVID-19 infection", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22891, "first_name": "Min", "last_name": "He", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "1997-06-16", "end_date": "2024-04-30", "award_amount": 420500, "principal_investigator": { "id": 22892, "first_name": "CANDACE S.", "last_name": "JOHNSON", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1148, "ror": "", "name": "ROSWELL PARK CANCER INSTITUTE CORP", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1148, "ror": "", "name": "ROSWELL PARK CANCER INSTITUTE CORP", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Following infection with the novel coronavirus SARS-CoV-, immunocompromised and older individuals are at higher risk of severe illness and fatality. Patients with cancer exhibit multiple factors associated with elevated morbidity and mortality from COVID-19, including older age, pre-existing cardiac and lung disease, and immune impairment from the underlying malignancy and chemotherapy. While the innate immune response is the first line of antiviral defense against SARS-CoV-2, coronavirus infection is accompanied by suppression of type I interferon (IFN), thereby limiting activation of innate immune pathways required for immediate control of infection and adaptive immunity. Coronavirus-mediated inhibition of innate immunity via the type I IFN pathway allows the virus to replicate in epithelial cells, and particularly in high-risk patients, progress to pneumonia and respiratory failure. The mechanisms include inhibition of intracellular signaling driven by pattern recognition receptors (e.g. RIG-I and MDA5) and suppression of IRF-3, a transcriptional factor that induces the expression of type 1 interferons. Consequently, we hypothesize that augmentation of innate immunity during early mild or moderately severe infection might avert progression to respiratory failure and mortality. Rintatolimod, a selective dsRNA ligand of TLR3, has strong antiviral activity against multiple viruses including the coronavirus SARS-CoV-1 in vitro and in animal models. The combination of recombinant IFN (Intron-A) and rintatolimod is currently being evaluated in clinical trials developed by our group at Roswell Park (NCT03403634, NCT03599453, NCT03899987) for patients with multiple solid tumors. In this proposal, we will re-purpose these agents to test whether the synergistic combination therapy will overcome the defective ability to induce type I IFN and stimulate TLR-mediated immune activation to provide protection from viral infection. Patients with cancer and mild or moderate COVID-19 within the Roswell Park catchment area will be enrolled over 6 months. Roswell Park has been selected by New York State as a regional testing area for COVID-19. The principal endpoint is safety of rintatolimod and Intron-A. Secondary endpoints are: (i) progression of infection requiring hospitalization; (ii) respiratory failure requiring mechanical ventilation; and (iii) death within 30 days Biospecimens collected from all patients will be used for translational assays, including kinetics of 1) viral clearance from nasal swabs and serum; 2) circulating inflammatory mediators; and 3) immunophenotype of lymphocyte subsets. Overall significance: We will repurpose the combination of two antiviral agents, which showed safety and promising results in patients with advanced cancer, to stop viral replication and mitigate the risk of progression to severe COVID19 in patients with cancer and SARS-CoV-2 infection. We expect to establish the safety of rIFNα and Rintatolimod in patients with cancer and COVID-19 and create the foundation for a larger multi-center randomized trial to test efficacy.", "keywords": [ "2019-nCoV", "Advanced Malignant Neoplasm", "Age", "Animal Model", "Antiviral Agents", "Area", "Award", "Basic Science", "Biological Assay", "COVID-19", "Cancer Center", "Cancer Center Support Grant", "Cancer Patient", "Cancer Science", "Catchment Area", "Cessation of life", "Clinic", "Clinical", "Clinical Trials", "Combined Modality Therapy", "Communities", "Community Outreach", "Comprehensive Cancer Center", "Coronavirus", "Coronavirus Infections", "Country", "Development", "Discipline", "Double-Stranded RNA", "Enrollment", "Epithelial Cells", "Exhibits", "Faculty", "Faculty Recruitment", "Foundations", "Funding", "Genomic medicine", "Grant", "Growth", "Heart Diseases", "Hospitalization", "Human Resources", "Immune", "Immunocompromised Host", "Impairment", "In Vitro", "Individual", "Infection", "Infection Control", "Inflammation Mediators", "Infrastructure", "Innate Immune Response", "Interferon Type I", "Interferon-alpha", "Interferons", "Intervention", "Introns", "Kinetics", "Laboratories", "Leadership", "Ligands", "Lung diseases", "Lymphocyte Immunophenotypings", "Lymphocyte Subset", "Malignant Neoplasms", "Mechanical ventilation", "Mediating", "Mission", "Molecular Epidemiology", "Morbidity - disease rate", "National Cancer Institute", "Natural Immunity", "New York", "Nose", "Oncology", "Pathway interactions", "Patients", "Pattern recognition receptor", "Phase", "Play", "Pneumonia", "Population", "Population Sciences", "Prevention education", "Prevention strategy", "Recombinants", "Recording of previous events", "Regimen", "Request for Applications", "Research", "Research Personnel", "Resource Sharing", "Resources", "Respiratory Failure", "Risk", "Role", "SARS coronavirus", "Safety", "Science", "Scientist", "Serum", "Signal Transduction", "Solid Neoplasm", "Swab", "TLR3 gene", "Testing", "Therapeutic", "Training", "Viral", "Virus", "Virus Diseases", "Virus Replication", "adaptive immunity", "anticancer research", "cancer care", "cancer education", "cancer prevention", "cancer therapy", "chemotherapy", "efficacy testing", "experience", "high risk", "immune activation", "innate immune pathways", "innovation", "investigator-initiated trial", "member", "mortality", "neoplasm immunotherapy", "next generation", "novel coronavirus", "outreach", "peer", "population based", "prevent", "programs", "randomized trial", "recruit", "secondary endpoint", "survivorship", "transcription f" ], "approved": true } } ], "meta": { "pagination": { "page": 1383, "pages": 1397, "count": 13961 } } }