Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1383&sort=-program_officials
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Specifically we aim to perform influenza virus hemagglutination inhibition (HI) testing of serum samples already collected from PHIRST-C participants in a rural and an urban site and from HUTS participants in 2 key communities before and after the 2021 influenza season to determine rates of recent influenza infection. We also aim to characterize healthcare seeking behavior for respiratory illness during the influenza season in the year following the South African COVID-19 epidemic first and second waves through a survey conducted following the influenza season and compare healthcare seeking behavior for respiratory illness to a survey conducted before the 2021 influenza season and assess the impact of different factors on healthcare seeking behavior. We aim to describe the prevalence of MTB-SARS-CoV-2 coinfection and the impact of coinfection on clinical presentation and outcomes in patients presenting with ILI or suspected COVID-19 at ILI surveillance sites or patients admitted with SRI at pneumonia surveillance sites in South Africa. We aim to pilot the implementation of laboratory-confirmed influenza surveillance among individuals participating to the CoughWatchSA participatory digital surveillance platform, compare influenza virus circulation as detected in facility-based surveillance and through the CoughWatchSA platform and to evaluate concordance between self-reported ARI on the CoughWatchSA platform and laboratory-confirmed infection with influenza. This will be achieved through testing of collected serum samples for the presence of anti-influenza antibodies using HI assay, performing a survey of healthcare utilization and serosurvey at two sites in South Africa and implementation of systematic Mycobacterium tuberculosis testing of all participants enrolled in existing pneumonia and influenza-like illness surveillance programmes. Lastly we will pilot self- swabbing of individuals participating in the Coughwatch app for syndromic influenza surveillance.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8722", "attributes": { "award_id": "1P50MD017348-01", "title": "A Cardiometabolic Health Program LINKED with Clinical-Community Support and Mobile HEAlth TelemonitoRing in Underserved PopulaTionS (LINKED-HEARTS PROGRAM)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-24", "end_date": "2026-06-30", "award_amount": 702093, "principal_investigator": { "id": 24505, "first_name": "Yvonne", "last_name": "Commodore-Mensah", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24506, "first_name": "Cheryl", "last_name": "Dennison Himmelfarb", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Innovation in chronic disease management is urgently needed to effectively control hypertension (HTN) and diabetes, conditions which affect millions of Americans. Uncontrolled HTN and diabetes cause cardiovascular disease, stroke, chronic kidney disease (CKD), and premature death. However, these conditions are poorly controlled despite the availability of effective and affordable therapy. A pressing priority is reducing disparities in the management and control of chronic diseases and making primary care more convenient for underserved populations. Black and Hispanic adults are disproportionately affected by HTN and diabetes than White adults. They also experience more adverse social determinants of health, including a lack of access to reliable transportation and fragmented access to primary care. Team-based care including community health workers and pharmacists are “best practices” in improving HTN and diabetes control. Telehealth has become a cornerstone of efforts to minimize disruptions in primary care and can be enhanced with remote patient monitoring devices. The COVID-19 pandemic has spurred efforts to increase access to timely and appropriate care through re-engineering primary care to be patient-centered and digitally-enabled. Sphygmo Home, a remote patient telemonitoring solution that links with validated blood pressure (BP) and glucose monitoring devices is a promising solution to improve patient's self-management of HTN and diabetes. We have designed the LINKED-HEARTS Program, an innovative, theoretically derived, patient-centered, multi-level intervention to address individual and community-level social determinants that affect chronic disease management. The LINKED-HEARTS Program focuses on addressing structural issues of access and includes a self-measured BP(SMBP) and blood glucose telemonitoring platform; team-based care including a pharmacist and community health worker and provider-level interventions. Using a hybrid type I effectiveness-implementation design, our proposed specific aims are 1) To compare the effect of the LINKED-HEARTS Program versus SMBP alone in improving BP control (systolic BP<140/90 mm Hg) and improving patient-centered outcomes at 6 and 12 months, in a cluster-randomized controlled trial of adults with uncontrolled HTN and either diabetes or CKD. 2) To use the Pragmatic Robust Implementation and Sustainability Model (PRISM) to evaluate the reach, adoption, maintenance of the LINKED-HEARTS program at 12 and 24 months post-randomization and explore contextual factors that associated with adoption and maintenance of the program. We will enroll 600 adults, clustered in 16 practices including federally qualified healthcare centers. Through early and continued stakeholder engagement with health system leaders, providers, patients, and our community, we seek to close the wide “know-do-gap” and reduce chronic disease disparities. We also propose a comprehensive dissemination strategy to reach critical audiences and achieve buy-in and policy change.", "keywords": [ "Address", "Adherence", "Adoption", "Adult", "Affect", "African American", "American", "Behavioral", "Biological", "Black race", "Blood Glucose", "Blood Pressure", "Blood Pressure Monitors", "Bluetooth", "COVID-19 pandemic", "Cardiovascular Diseases", "Caring", "Cessation of life", "Chronic", "Chronic Disease", "Chronic Kidney Failure", "Clinic", "Clinical", "Communities", "Community Health Aides", "Complex", "Data", "Devices", "Diabetes Mellitus", "Disease Management", "Education", "Engineering", "Enrollment", "Ethnic group", "Glycosylated hemoglobin A", "Health", "Health Professional", "Health Services Accessibility", "Health Technology", "Health behavior", "Health system", "Healthcare", "High Prevalence", "Hispanics", "Home", "Hybrids", "Hypertension", "Improve Access", "Individual", "Intervention", "Kidney Diseases", "Latino", "Link", "Maintenance", "Measures", "Minority Groups", "Monitor", "Morbidity - disease rate", "Not Hispanic or Latino", "Organ", "Patient-Focused Outcomes", "Patients", "Persons", "Pharmacists", "Plant Roots", "Policies", "Population", "Practical Robust Implementation and Sustainability Model", "Prevalence", "Primary Health Care", "Provider", "Randomized", "Randomized Controlled Trials", "Self Management", "Soil", "Stroke", "Structure", "System", "Time", "Transportation", "Underserved Population", "Uninsured", "Visit", "Work", "base", "blood pressure regulation", "cardiometabolism", "cardiovascular disorder risk", "cardiovascular risk factor", "care delivery", "clinical decision-making", "community clinic", "contextual factors", "design", "diabetes control", "diabetes risk", "digital", "disease disparity", "disparity reduction", "dissemination strategy", "effectiveness implementation design", "ethnic minority population", "evidence based guidelines", "experience", "glucose monitor", "health care availability", "health disparity", "health equity", "high risk", "hypertension control", "improved", "innovation", "mHealth", "monitoring device", "mortality", "patient monitoring device", "patient oriented", "premature", "prevent", "primary outcome", "programs", "racial and ethnic", "racial minority", "randomized trial", "remote patient monitoring", "secondary outcome", "social", "social culture", "social determinants", "social health determinants", "telehealth", "telemonitoring" ], "approved": true } }, { "type": "Grant", "id": "8723", "attributes": { "award_id": "1S06GM142123-01", "title": "ASU Faculty Enhancement: Wastewater-based epidemiology: relevant health metrics in Tribal communities.", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-23", "end_date": "2025-07-31", "award_amount": 154762, "principal_investigator": { "id": 4742, "first_name": "Otakuye", "last_name": "Conroy-Ben", "orcid": null, "emails": "[email protected]", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 147, "ror": "https://ror.org/03efmqc40", "name": "Arizona State University", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1017, "ror": "", "name": "INTER TRIBAL COUNCIL OF ARIZONA, INC.", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true }, "abstract": "Wastewater-based epidemiology (WBE) is a powerful tool that can measure population health in communities with centralized sewer treatment systems and is particularly relevant for Tribes who wish to assess health disparities such as COVID and substance abuse. In WBE, chemical metabolites, bacteria and viruses, and other health indicators are measured in excreted human waste products in wastewater. The wastewater flow rate and population load into the sewershed allow for calculation of community-level human health indicators present in water. WBE has not been documented in Tribal communities prior to the PI’s efforts, and there are knowledge gaps related to the execution, acceptability, and applicability of this tool to assess Tribal population health. Our specific aims are to (1) develop a framework for conducting responsible WBE research and surveillance in Tribal communities, which will address data sovereignty, Tribal sewer infrastructure and personnel, and handling of environmental biospecimens; (2) assess the perceptions of using WBE by Tribal leaders, health administrators, and community members through surveys; and (3) determine and quantify relevant health metrics that can be measured by WBE, including infectious disease, pollutant exposure, the gut microbiome, and substance abuse. This faculty enhancement award under ITCA’s NARCH XI will provide directed mentorship and training to the PI from ITCA staff. This collaborative project will develop research capacity for ITCA, partner Tribes in Arizona and the faculty member through collection of preliminary data, leading to development of larger projects with ITCA and the partner intertribal consortia for future WBE studies.", "keywords": [ "Address", "Administrator", "Agreement", "Area", "Arizona", "Award", "Bacteria", "Biological", "Chemicals", "Collection", "Communicable Diseases", "Communities", "Coronavirus", "Data", "Development", "Diabetes Mellitus", "Engineering", "Epidemiologic Monitoring", "Ethics", "European", "Exposure to", "Faculty", "Future", "Goals", "Health", "Health Benefit", "Health Status", "Human", "Human Resources", "Immunization", "Indian reservation", "Infrastructure", "Institutional Review Boards", "Investments", "Knowledge", "Measures", "Mentors", "Mentorship", "Native American Research Center for Health", "Perception", "Pharmaceutical Preparations", "Population", "Protocols documentation", "Public Health", "Qualitative Research", "Recommendation", "Research", "Research Personnel", "Resources", "Rural", "Sampling", "Substance abuse problem", "Surveys", "System", "Training", "Tribes", "Universities", "Virus", "Waste Products", "Water", "Work", "career", "college", "contaminated water", "coronavirus disease", "data dissemination", "epidemiology study", "experience", "faculty mentor", "gut microbiome", "health disparity", "indigenous community", "intertribal", "member", "metropolitan", "novel", "pollutant", "population health", "professor", "responsible research conduct", "skills", "tool", "tribal community", "tribal health", "tribal leader", "tribal member", "wastewater epidemiology", "wasting" ], "approved": true } }, { "type": "Grant", "id": "8728", "attributes": { "award_id": "1P01AA029544-01", "title": "Alcohol Research Consortium in HIV: Epidemiology Research Arm", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Alcohol Abuse and Alcoholism (NIAAA)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-10", "end_date": "2026-08-31", "award_amount": 185680, "principal_investigator": { "id": 9246, "first_name": "Heidi M.", "last_name": "Crane", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 159, "ror": "https://ror.org/00cvxb145", "name": "University of Washington", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Unhealthy alcohol use is prevalent among people with HIV (PWH) and associated with poor outcomes including less engagement in the HIV Care Continuum (HIV-CC) and increased age-related comorbidities. Alcohol Research Consortium in HIV–Epidemiology Research Arm (ARCH-ERA) was formed to investigate short and long-term effects of alcohol on outcomes among PWH in the CFAR Network of Integrated Clinical Systems (CNICS). CNICS is an 8-site network that is a large, geographically and racially diverse, gender representative cohort of >37,000 PWH in care. Careful outcomes adjudication, a large diverse population, and systematic longitudinal assessments of patient reported alcohol use, drug use, mental health symptoms, adherence, and context-based factors such as housing status, stigma, and social support enables a rigorous approach to key questions on HIV and alcohol that are highly responsive to NIH HIV priorities and RFA-AA-20- 009. Our rapid response to the COVID-19 pandemic demonstrates the remarkable agility of CNICS to adapt to changes in health care and research priorities as they emerge. We have previously described the high prevalence of unhealthy alcohol use among PWH, and its detrimental effects on outcomes including HIV-CC steps. We build on that work focusing on the HIV-CC in the current era of a pandemic and expanding telehealth; expanding focus to including the Alcohol Care Continuum (Alc-CC) as well as additional patterns of alcohol use; adding age-related outcomes such as heart failure that are becoming increasingly important in the aging population of PWH; and incorporating emerging outcomes such as due to COVID-19-related illness. Capitalizing on the resources and infrastructure of CNICS, we propose the following aims: 1. Obtain, expand, improve, and validate high quality alcohol and social determinants of health data including expanding CNICS PROs to better capture alcohol use patterns and adding U.S. Census data to better capture socioeconomic context; 2. Examine longitudinal relationships of alcohol use, drug use, and mental health disorders on the HIV-CC and Alc-CC including impacts of the pandemic and key social determinants of health such as among sometimes hidden or marginalized groups of PWH. 3. Determine clinical outcomes among PWH with unhealthy alcohol use including age-related comorbidities and COVID-19 related illness, and the role of alcohol use patterns and social determinants of health on these and other long-term outcomes. ARCH-ERA will capitalize on and expand CNICS’s comprehensive clinical data to address novel research questions on the impact of alcohol use among PWH including generating new knowledge on the intersection of HIV and alcohol to inform future research and clinical care. ARCH-ERA will enhance the overall ARCH consortium by providing new and expanded data types, informing alcohol interventions, and leveraging results from this rich cohort to provide data and address important questions focusing on the impact of alcohol use patterns on current care and health outcomes of PWH within the modern pandemic context.", "keywords": [ "Address", "Adherence", "Admission activity", "Alcohol consumption", "Alcohols", "Anxiety", "Atrial Fibrillation", "Biostatistical Methods", "COVID-19", "COVID-19 pandemic", "Caring", "Censuses", "Clinical", "Clinical Data", "Clinical assessments", "Collaborations", "Communities", "Continuity of Patient Care", "Data", "Data Collection", "Disease", "Drug usage", "Epidemic", "Epidemiology", "Gender", "Geography", "HIV", "Health", "Health Care Research", "Heart failure", "High Prevalence", "Homelessness", "Hospitalization", "Housing", "Imprisonment", "Incidence", "Individual", "Infrastructure", "Intervention", "Intubation", "Joints", "Knowledge", "Liver diseases", "Long-Term Effects", "Longevity", "Mental Depression", "Mental Health", "Mental disorders", "Modeling", "Modernization", "Outcome", "Patient Outcomes Assessments", "Patients", "Pattern", "Population Heterogeneity", "Poverty", "Reporting", "Research", "Research Priority", "Resources", "Risk", "Role", "Severities", "Site", "Social Distance", "Social isolation", "Social support", "Standardization", "Statistical Models", "Street Address", "Structural Models", "Symptoms", "System", "United States National Institutes of Health", "Viral", "Work", "adjudicate", "adjudication", "age related", "aging population", "alcohol comorbidity", "alcohol effect", "alcohol intervention", "alcohol misuse", "alcohol research", "alcohol use disorder", "antiretroviral therapy", "arm", "base", "binge drinking", "cerebrovascular", "clinical care", "cohort", "comorbidity", "disease transmission", "disparity reduction", "epidemiology study", "experience", "flexibility", "food insecurity", "frailty", "health care delivery", "health data", "health related quality of life", "improved", "innovation", "marginalized population", "mortality", "novel", "pandemic disease", "racial diversity", "response", "social health determinants", "social stigma", "socioeconomics", "success", "telehealth", "thrombotic complications", "transgender women", "venous thromboembolism" ], "approved": true } }, { "type": "Grant", "id": "8733", "attributes": { "award_id": "1S06GM142120-01", "title": "Bright Horizons: Designing and Evaluating a Brief Intervention to Address Alcohol, Opioid, and other Substance Use among At-Risk Apaches", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-24", "end_date": "2025-07-31", "award_amount": 217330, "principal_investigator": { "id": 23624, "first_name": "Mary", "last_name": "Cwik", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1744, "ror": "", "name": "WHITE MOUNTAIN APACHE TRIBE", "address": "", "city": "", "state": "AZ", "zip": "", "country": "United States", "approved": true }, "abstract": "1 While opioid use has been a necessary focus of recent national attention, general US rates of 2 alcohol use, binge drinking, and alcohol-related deaths are rising including among adolescents, 3 with some of the highest disparities for Native Americans. Alcohol has long been a tool of 4 colonizers to oppress Native people and purposefully inflict harm. Substance use is being further 5 impacted by the COVID-19 pandemic, felt more acutely for disadvantaged communities. While 6 there are some promising, evidence-based interventions to address substance use problems, 7 rigorous research on these interventions in Native communities is lacking. Recognizing the 8 prevalence of binge substance use within their community and making novel use of tribal 9 sovereignty, the White Mountain Apache Tribe mandated reporting of binge alcohol use to their 10 suicide and self-harm surveillance system and conducted a series of research studies. Bright 11 Horizons is a promising, culturally adapted intervention that was subsequently developed in the 12 final phase of a previous NARCH grant based on some of this initial research but has not been 13 evaluated. Bright Horizons is a brief intervention that includes cognitive behavioral therapy 14 (CBT) and motivational interviewing (MI) to reduce alcohol and other substance use and connect 15 individuals with treatment. Our study aims are to: 1) to use a qualitative positive deviance 16 approach to identify strengths and skills of at-risk youth (12-17 years old: N=30) who do not use 17 substances to understand unique factors that may be relevant for a substance use prevention 18 intervention; 2) to adapt Bright Horizons, based on Aim 1 findings, the current literature, and 19 CAB input for piloting by Apache community mental health specialists (CMHS) with N=10 20 Apache youth with recent serious binge alcohol use; and 3) to test the effectiveness of Bright 21 Horizons using a randomized controlled trial with Apache adolescents (N=100) with recent 22 serious binge alcohol use. This study is innovative and will add to the literature by: a) designing 23 an intervention grounded in our own theoretical model informed by local data and other 24 Indigenous frameworks; b) implementing a brief intervention that while focused on alcohol, also 25 recognizes that adolescents, are engaged in polysubstance use and have changing substance use 26 patterns, and c) use of CMHS which serves as a model for transforming mental health care, the 27 necessity of which has become even more pronounced and evident during the COVID-19 crisis. 28 This grant is locally led by two Apache Co-Investigators with their Master's degrees, enrolled in 29 part-time doctoral programs in mental health, and supports an additional 4 Apache team 30 members who will receive training in substance use intervention and research.", "keywords": [ "17 year old", "Acute", "Address", "Adolescent", "Adult", "Age", "Aggressive behavior", "Alcohol consumption", "Alcohol-Related Disorders", "Alcohols", "American Indians", "Apache", "Apache Tribe", "Attention", "COVID-19", "COVID-19 pandemic", "Case-Control Studies", "Cognitive Therapy", "Collaborations", "Communities", "Data", "Decision Making", "Disadvantaged", "Drug usage", "Educational Curriculum", "Elements", "Enrollment", "Ensure", "Ethics", "Evidence based intervention", "Family", "Foundations", "Friends", "Funding", "Goals", "Grant", "Healthcare", "Home", "Impulsivity", "Indigenous", "Individual", "Intervention", "Interview", "Knowledge", "Literature", "Logistics", "Master&apos", "s Degree", "Mental Health", "Mentors", "Modeling", "Native American Research Center for Health", "Native Americans", "Native-Born", "Opioid", "Participant", "Pattern", "Peer Pressure", "Phase", "Population", "Prevalence", "Problem Solving", "Process", "Public Health", "Qualitative Methods", "Qualitative Research", "Race", "Randomized Controlled Trials", "Reporting", "Research", "Research Methodology", "Research Personnel", "Risk", "Risk Factors", "Schools", "Self-Injurious Behavior", "Series", "Severities", "Social Problems", "Specialist", "Suicide", "System", "Techniques", "Theoretical model", "Time", "Training", "White Mountain Apache", "Youth", "alcohol abstinence", "alcohol-related death", "barrier to care", "base", "behavioral health", "binge drinking", "brief intervention", "data management", "design", "deviant", "deviant peer", "drinking", "effectiveness testing", "emotion regulation", "ethnic minority population", "experience", "follow-up", "innovation", "intervention participants", "member", "mortality", "motivational enhancement therapy", "native youth", "novel", "opioid use", "peer", "polysubstance use", "post intervention", "preventive intervention", "programs", "protective factors", "research study", "service delivery", "skills", "substance abuse prevention", "substance use", "substance use prevention", "therapy development", "tool", "tribal health" ], "approved": true } }, { "type": "Grant", "id": "8747", "attributes": { "award_id": "1R43IP001169-01A1", "title": "Rapid mass production of human influenza vaccine in insects using genome editing", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-30", "end_date": "2022-09-29", "award_amount": 243000, "principal_investigator": { "id": 24538, "first_name": "Virginia", "last_name": "Emery", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 1747, "ror": "", "name": "BETA HATCH INC.", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 1747, "ror": "", "name": "BETA HATCH INC.", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "As the recent COVID-19 pandemic has made clear, the rapid mass production of vaccines for emerging infectious diseases is of paramount importance. The use of the baculovirus/insect cell expression system for in vitro protein expression has been a game changer for vaccine production, but it also introduces challenges: transfection can be difficult, needs to be repeated with every batch, and the final product requires multiple purification steps to remove the residual baculovirus. We propose an alternative approach that could side-step the drawbacks associated with baculovirus/insect cell expression system: in vivo vaccine production in a scalable insect non-mammalian genetic model system. We aim to achieve this by using the CRISPR-Cas9 system to insert viral antigen genes for human and avian influenza into insects that are already mass produced for feed and/or waste management. Both the yellow mealworm (Tenebrio molitor) and the blow fly (Phormia regina) are promising bioreactors for manipulating protein expression in vivo due to their high metabolism and fecundity, ease of rearing, high resilience, and versatility in mass production systems (large-scale production facilities already exist for both insects). Unlike existing transgenic insect hosts such as cabbage looper larvae, both mealworms and blowflies are gregarious and can be cost effectively mass-reared at a scale of several tons per day. By using the CRISPR-Cas9 technique for recombinant protein expression to express influenza antigens in these insects, we will engineer life-stage dependent activation of the antigen production. Using existing technologies to facilitate rapid antigen protein purification, we will confirm the antigen production and characterize it. Finally, we will quantify what impact (if any) the modified genome has on phenotypes relevant to mass production and validate cost considerations for production. This work will set the stage for a steady supply of low-cost and customizable antigens, using insect biomass as an affordable and scalable bioreactor.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8749", "attributes": { "award_id": "1U01IP001157-01", "title": "IP21-002, Enhanced Surveillance to Assess Vaccine Preventable Enteric and Respiratory Virus Illnesses", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-01", "end_date": "2026-08-31", "award_amount": 1441645, "principal_investigator": { "id": 24541, "first_name": "JANET A", "last_name": "ENGLUND", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 732, "ror": "https://ror.org/01njes783", "name": "Seattle Children's Hospital", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [ { "id": 24542, "first_name": "Eileen", "last_name": "Klein", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 732, "ror": "https://ror.org/01njes783", "name": "Seattle Children's Hospital", "address": "", "city": "", "state": "WA", "zip": "", "country": "United States", "approved": true }, "abstract": "We will conduct active, prospective inpatient, emergency department (ED) and asymptomatic healthy control (HC) surveillance in children at SCH and affiliated clinics in the Seattle metropolitan area. We will enroll subjects to describe the population-based burden of AGE and ARI in King County and Snohomish County, WA and evaluate effectiveness of licensed vaccines, such as influenza (Flu) and rotavirus (RV) vaccine (vx). We will assess the epidemiology and natural history of pediatric respiratory and enteric viral diseases and assess transmission dynamics for vx-preventable (RV, Flu) and potentially vx-preventable pathogens, such as norovirus (NV), respiratory syncytial virus (RSV), and SARS-CoV-2. After obtaining informed consent and assent, if applicable, in English or Spanish, we will interview families to collect epidemiological and clinical information, vaccine history, and obtain study specimens including respiratory and/or stool specimens, depending on clinical symptoms. Vaccination data are recorded in our state vaccine database, which is very reliable and complete. During times of COVID-19, novel methods of enrollment and capturing data may be utilized as per IRB- approved protocols including verbal or online consent, telephone interviews to complete data capture, and home specimen collection. Respiratory specimens and stool samples will be tested for multiple respiratory and enteric pathogens using sensitive and specific molecular PCR tests in laboratories using approved testing strategies that have been validated by proficiency testing. With this information, in addition to publicly available state-wide data describing inpatient and acute care visits in WA, we will obtain incidence rates of ED and inpatient visits and characterization of illness for multiple viral pathogens, including those responsible for vx- preventable disease and potentially vx-preventable disease, and others related to acute respiratory and enteric diseases, such as rhinovirus, EVD-68, parainfluenza viruses, adenoviruses, and human metapneumovirus. Additionally, we will continue ongoing surveillance for Acute Flaccid Myelitis (AFM) throughout WA state. In collaboration with statewide AFM expert and SCH neurologist, Dr. Catherine Otten and using WA DOH surveillance data we will conduct active surveillance, establish incidence rates, and compare rates of AFM to current circulation of respiratory and gastrointestinal infections. We will characterize the clinical spectrum of AFM by evaluating clinical and laboratory data, MRI findings, therapeutic interventions, and outcomes to inform early diagnosis, prognosis, prevention, and treatment.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "8753", "attributes": { "award_id": "1P50MD017319-01", "title": "FRESH Delivers: An Innovative Approach to Reducing Tobacco Use Among Rural Black/African American Smokers", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Minority Health and Health Disparities (NIMHD)" ], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-24", "end_date": "2026-06-30", "award_amount": 645796, "principal_investigator": { "id": 24546, "first_name": "Pebbles", "last_name": "Fagan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 772, "ror": "", "name": "UNIV OF ARKANSAS FOR MED SCIS", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 772, "ror": "", "name": "UNIV OF ARKANSAS FOR MED SCIS", "address": "", "city": "", "state": "AR", "zip": "", "country": "United States", "approved": true }, "abstract": "– PROJECT 2 Blacks/African Americans have the highest cigarette smoking-attributable cancer mortality rates in the United States. Cigarette smoking is nearly double the national average (23%-26%) in Arkansas rural counties where more than 48% of the population is Black/African American. Social structural stressors such as persistent poverty, low educational attainment, high rates of unemployment, the COVID-19 pandemic, poor transportation, poor access to health care, and historical oppression pose tremendous barriers to successful quitting. Quitting smoking can substantially reduce cancer morbidity and mortality among African Americans, but successful quitting as well as the reach of evidence-based interventions to rural African Americans is alarmingly low. Few studies have empirically tested the efficacy of social structural interventions (home-based food delivery) that address the dynamic interplay of cancer risk behaviors, like smoking, and social factors that perpetuate disparities like food insecurity. The long-term goal of this study is to fill a critical gap in knowledge on the role of social structural interventions in the elimination of cancer health disparities in low resource rural Arkansas counties with high proportions of Blacks/African Americans and high smoking prevalence. Our aims are to 1) test the efficacy of a social change intervention (home-based food delivery) on smoking abstinence using a 3-armed randomized controlled design, 2) examine changes in measures of cigarette abuse liability, and 3) examine the extent to which home-based food delivery improves recruitment and retention of Black/African American smokers in the treatment conditions. Our academic-community partnership – the University of Arkansas for Medical Sciences, Coalition for a Tobacco Free Arkansas, and the Arkansas Foodbank – has a strong collaborative foundation and experience in working together to reduce tobacco use in rural Arkansas Delta counties with high proportions of Blacks/African Americans. Multilevel interventions are needed to address persistent social conditions that potentially increase the abuse liability of smoking and impede successful quitting. Smokers who are more food insecure are less likely to quit smoking. Our multidisciplinary team will use the Socioecological Model to test our central hypothesis: smokers who receive evidence-based real-time video-based motivational counseling and a social change intervention (home-based food delivery) will have greater cotinine-verified 7-day point prevalence abstinence than those who receive motivational counseling alone or social change alone. Social structural interventions that meet the immediate social needs of Black/African American smokers hold tremendous promise for improving Black/African American recruitment and retention into helpful cancer prevention community trials, increasing successful quitting, and reducing social disparities that perpetuate tobacco-caused cancer disparities.", "keywords": [ "Abstinence", "Acetaldehyde", "Acrolein", "Address", "African American", "Arkansas", "Benzaldehyde", "Biological Markers", "Body mass index", "COVID-19 pandemic", "Cancer Etiology", "Carbon Monoxide", "Cessation of life", "Chronic Disease", "Cigarette", "Community Trial", "Consumption", "Cotinine", "Counseling", "County", "Discrimination", "Dose", "Evidence based intervention", "Face", "Failure", "Food", "Food Access", "Formaldehyde", "Foundations", "Goals", "Health", "Health Food", "Healthcare", "Home", "Income", "Intervention", "Knowledge", "Malignant Neoplasms", "Measures", "Medical", "Modeling", "Morbidity - disease rate", "Motivation", "Nicotine Dependence", "Population", "Poverty", "Prevalence", "Preventable cancer cause", "Research", "Resources", "Risk Behaviors", "Role", "Rural", "Science", "Smoker", "Smoking", "Social Change", "Social Conditions", "Social Justice", "Structural Racism", "Structure", "System", "Testing", "Time", "Tobacco", "Transportation", "Unemployment", "United States", "Universities", "Withdrawal", "arm", "attributable mortality", "base", "cancer health disparity", "cancer prevention", "cancer risk", "cigarette smoking", "community partnership", "craving", "effective intervention", "efficacy testing", "evidence base", "experience", "food insecurity", "food security", "fruits and vegetables", "health care availability", "health disparity", "hydroxycotinine", "improved", "innovation", "mortality", "multidisciplinary", "novel", "programs", "randomized controlled design", "recruit", "reduce tobacco use", "rural African American", "rural counties", "smoking abstinence", "smoking cessation", "smoking prevalence", "social", "social disparities", "social factors", "social interventions", "social stressor", "social structure", "stressor", "tobacco exposure", "tobacco-free", "treatment group", "trend", "voucher" ], "approved": true } }, { "type": "Grant", "id": "8767", "attributes": { "award_id": "1U01IP001156-01", "title": "Enhanced Surveillance for New Vaccine Preventable Diseases", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2021-09-01", "end_date": "2026-08-31", "award_amount": 1441645, "principal_investigator": { "id": 24567, "first_name": "NATASHA Bassam", "last_name": "HALASA", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 456, "ror": "https://ror.org/05dq2gs74", "name": "Vanderbilt University Medical Center", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true } ] }, "other_investigators": [], "awardee_organization": { "id": 456, "ror": "https://ror.org/05dq2gs74", "name": "Vanderbilt University Medical Center", "address": "", "city": "", "state": "TN", "zip": "", "country": "United States", "approved": true }, "abstract": "- Mandatory Component A Acute respiratory illness (ARI) and acute gastroenteritis (AGE) are the leading causes of death worldwide in young children. Established leading viral etiologies of AGE are rotavirus and norovirus and respiratory syncytial virus (RSV) and influenza virus for ARI. Our understanding of ARI and AGE epidemiology is constantly changing due to spatiotemporal fluctuations, discovery of new or re-emerging pathogens [e.g. enterovirus D68 (EV-D68) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)], and use of rotavirus and influenza vaccines. Hence, surveillance efforts are imperative to define ARI and AGE disease burden, causative pathogens, outcomes, and vaccine impact. The primary influenza prevention strategy in the United States is vaccination for all individuals six months or older. There is a paucity of data regarding vaccine effectiveness (VE) against laboratory-confirmed influenza in children, and influenza viruses and vaccine antigenic components change annually. Therefore, perpetual assessments of VE are needed to monitor the impact of influenza vaccination on disease and inform strategies to improve magnitude, durability, and breadth of protection. Pediatric SARS-CoV-2 vaccines are an urgent public-health priority and likely will become available on an accelerated timeline in an effort to curb the COVID-19 pandemic. Rigorous, prospective surveillance of SARS-CoV-2 VE is crucial to support reliance on vaccines as primary prevention. Thus, the first main objective of this project is to conduct population-based active surveillance for respiratory and enteric viral pathogens in pediatric inpatient and emergency department settings and asymptomatic controls. Our team of Vanderbilt investigators is highly experienced in conducting prospective, population- based ARI and AGE surveillance. We propose to conduct ARI and AGE surveillance with the following specific aims: 1) To perform prospective, active surveillance to determine the etiology and burden of inpatient and emergency department (ED) acute viral respiratory and enteric diseases among the pediatric population. 2) To characterize the clinical and epidemiologic factors of pediatric infections (including in asymptomatic children) through active surveillance. 3) To evaluate vaccine effectiveness and impact of vaccines and other interventions (e.g., immunoprophylaxis with antiviral agents or other therapeutics) available or projected to become available during the period of performance. The second main objective of this project is to conduct surveillance and epidemiologic characterization of acute flaccid myelitis syndrome in children. Given the epidemiologic connection between EV-D68 infection and acute flaccid myelitis (AFM), it will be important to conduct rigorous, active, longitudinal surveillance for AFM across multiple consecutive seasons; carefully define AFM clinical spectrum, risk factors, incidence rates, and laboratory parameters; and document local circulation of EV-D68 and other ARI and AGE pathogens coincident with increased AFM occurrence. This work underpins development of preventive, diagnostic, and therapeutic strategies for AFM.", "keywords": [], "approved": true } } ], "meta": { "pagination": { "page": 1383, "pages": 1424, "count": 14236 } } }