Grant List
Represents Grant table in the DB
GET /v1/grants?page%5Bnumber%5D=1383&sort=-approved
{ "links": { "first": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1&sort=-approved", "last": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1419&sort=-approved", "next": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1384&sort=-approved", "prev": "https://cic-apps.datascience.columbia.edu/v1/grants?page%5Bnumber%5D=1382&sort=-approved" }, "data": [ { "type": "Grant", "id": "12311", "attributes": { "award_id": "1R01GM150187-01", "title": "Biophysical, Structural, and Cellular Dissection of COPI-Dependent Retrograde Trafficking Using a Coronavirus Toolkit", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of General Medical Sciences (NIGMS)" ], "program_reference_codes": [], "program_officials": [ { "id": 11852, "first_name": "Anne", "last_name": "Gershenson", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2028-08-31", "award_amount": 413345, "principal_investigator": { "id": 28219, "first_name": "Syed Saif", "last_name": "Hasan", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 793, "ror": "", "name": "UNIVERSITY OF MARYLAND BALTIMORE", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "The secretory pathway is responsible for the biogenesis of soluble and membrane proteins involved in communication, energy transduction, nutrient uptake, and defense. These proteins are synthesized in the endoplasmic reticulum (ER) and then trafficked to Golgi and other organelles such as the plasma membrane. This trafficking causes ER stress by accidental exodus of ER-resident proteins such as UDP-glucuronyl transferases (UGT’s). These are type I membrane proteins (T1MP’s) responsible for modifications of lipid hormones and of analgesics acetaminophen and morphine. These ER-resident T1MP’s display a dibasic sequence (Lys-x-Lys-x-x or Lys-Lys-x-x; x=any amino acid) in their cytosolic tail for ER-retrieval by the coatomer protein I complex (COPI). The α and β’ subunits of this hetero-heptameric complex bind this dibasic sequence to initiate T1MP packaging into vesicles originating from post-ER compartments such as cis-Golgi. These COPI coated vesicles traffic and deliver the T1MP proteins back to ER to restore secretory balance. However, the atomic principles underlying T1MP binding, release, and selective interactions with α and β’COPI subunits are not well understood. This is a critical knowledge-gap as T1MP release and escape from COPI modulate T1MP trafficking, post-translational modifications, and T1MP functions. COPI dysfunction has been implicated in a variety of disorders related to development, auto-immunity, and cancers. Our long-term objective is to gain fundamental insights into COPI-dependent retrograde trafficking of T1MP’s and the underlying atomic-level factors responsible for COPI dysfunction in diseases. In this grant, we will elucidate mechanistic insights into COPI recruitment, release, and T1MP post-translational modifications utilizing the coronavirus (CoV) spike protein, a T1MP with a dibasic Lys-x-His-x-x sequence, as a new model system. This dibasic sequence ensures COPI-dependent retrograde delivery of the spike from Golgi to the viral progeny assembly site in ER-Golgi intermediate compartment (ERGIC). In Aim 1, we will elucidate the atomic details of conformational modulation of COPI-spike interactions. In Aim 2, we will determine the principles that govern release from COPI and subsequent post-translational modifications of the spike. In Aim 3, we will elucidate the atomic basis of COPI subunit selectivity for the spike protein. These investigations will expand on a toolkit of spike mutants with modified COPI interactions, as recently published by our group. We will integrate structural approaches in X-ray crystallography, NMR, and Rosetta modeling with biophysical tools and cellular assays of secretory trafficking to gain unprecedented insights into fine modulation and conformational regulation of COPI-spike interactions. The innovative use of the spike protein as a T1MP model system will yield novel insights into fundamental secretory trafficking. These data will simultaneously opening avenues for the development of targeted therapeutics for COPI-selective disorders and for a deeper understanding of CoV assembly and processing of CoV vaccines.", "keywords": [ "2019-nCoV", "Accidents", "Acetaminophen", "Affect", "Amino Acids", "Analgesics", "Applications Grants", "Autoimmunity", "Back", "Binding", "Binding Proteins", "Binding Sites", "Biochemical", "Biogenesis", "Biological", "Biological Models", "Biophysics", "C-terminal", "COVID-19", "COVID-19 pandemic", "Cell membrane", "Cell physiology", "Cellular Assay", "Chimera organism", "Coated vesicle", "Coatomer Protein", "Communication", "Complex", "Coronavirus", "Coronavirus spike protein", "Data", "Destinations", "Development", "Devices", "Disease", "Disease Outbreaks", "Dissection", "Drug Metabolic Detoxication", "Electrostatics", "Endoplasmic Reticulum", "Ensure", "Environment", "Epidemic", "Equilibrium", "Functional disorder", "Future", "Glucuronosyltransferase", "Goals", "Golgi Apparatus", "Grant", "Health", "Heart", "Homeostasis", "Hormones", "Human", "Immune system", "Immunologics", "Interferometry", "Investigation", "Knowledge", "Lipids", "Malignant Neoplasms", "Mass Spectrum Analysis", "Membrane Proteins", "Middle East Respiratory Syndrome Coronavirus", "Modeling", "Modification", "Molecular Conformation", "Morphine", "Mutation", "Names", "Nutrient", "Organelles", "Pathway interactions", "Polysaccharides", "Post-Translational Protein Processing", "Process", "Protein Biosynthesis", "Proteins", "Publications", "Publishing", "Reagent", "Regulation", "Retrieval", "Role", "SARS-CoV-2 spike protein", "Site", "Stress", "Tail", "Testing", "Therapeutic", "Therapeutic Intervention", "Vesicle", "Viral", "Viral Proteins", "X-Ray Crystallography", "Xenobiotics", "biophysical tools", "coronavirus vaccine", "developmental disease", "endoplasmic reticulum stress", "experimental study", "gene product", "improved", "in silico", "innovation", "insight", "mimicry", "mutant", "novel", "novel coronavirus", "posters", "protein function", "protein transport", "receptor", "recruit", "secretory protein", "targeted treatment", "trafficking", "uptake" ], "approved": true } }, { "type": "Grant", "id": "12312", "attributes": { "award_id": "1R21AG081678-01", "title": "The impact of senescence on immune memory", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute on Aging (NIA)" ], "program_reference_codes": [], "program_officials": [ { "id": 23647, "first_name": "MULUALEM ENYEW", "last_name": "Tilahun", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-15", "end_date": "2025-08-31", "award_amount": 453163, "principal_investigator": { "id": 28220, "first_name": "Laura", "last_name": "Haynes", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1432, "ror": "", "name": "UNIVERSITY OF CONNECTICUT SCH OF MED/DNT", "address": "", "city": "", "state": "CT", "zip": "", "country": "United States", "approved": true }, "abstract": "It is well known that age-related changes in the immune system contribute to declines in the ability to mount a highly protective response following either infection or vaccination. While vaccination does improve the outcome of influenza (flu) infection in older adults, it is still foremost among all infectious diseases causing death and disability in this population. Importantly, aging impacts almost every aspect of the adaptive immune response to influenza including generation of virus-specific CD4 and CD8 T cell effectors, high affinity antibody production and generation of protective immune memory. One of the most prominent features of aging is the accumulation of senescent cells (SC) in various tissues and in this project, we will explore the role of SC in shaping the generation of protective immune memory following influenza infection. Cellular senescence is characterized by irreversible growth arrest that occurs when cells experience a stressor. Senescence has two main roles in an adult: one is to suppress cells that have incurred DNA or other damage to prevent them from transitioning into cancer, the other is to aid in wound healing. While SC are efficiently cleared by the immune system in young individuals, this is not the case as we get older. With chronological aging, the number of senescent cells increases, resulting in many age-related pathologies and diseases. In addition, factors secreted by senescent cells (the Senescence Associated Secretory Phenotype, SASP) can also have a direct impact on surrounding cells driving dysfunction and misdirected differentiation. In this project, we will use two experimental models to examine the impact of SC on the immune responses generated following an influenza infection, with a focus on generation of protective immune memory. The first is the p16-Trimodality Reporter (p16-3MR) transgenic mouse model developed in the Campisi lab and the second is the treatment of aged C57BL/6 mice with senolytics. Importantly, our preliminary studies have shown that eliminating SC in aged mice prior to flu infection has a negative impact on the generation of protective immune memory. The goal of this proposal is to further explore how deleting SC in aged mice impacts immunity and the transition from the effector phase to the generation of durable protective memory. This proposal has high translational significance as clinical trials for the senolytics for infectious diseases, such as COVID-19, are already underway and it is important to determine if this treatment could impair protective memory formation and leave at-risk older adults at risk for severe reinfection.", "keywords": [ "Adult", "Aging", "Alzheimer&apos", "s Disease", "Antibodies", "Antibody Affinity", "Antibody Formation", "Automobile Driving", "Body Weight decreased", "C57BL/6 Mouse", "CD8-Positive T-Lymphocytes", "COVID-19", "Cause of Death", "Cell Aging", "Cells", "Chronology", "Clinical Trials", "Communicable Diseases", "DNA", "Development", "Disease", "Elderly", "Experimental Models", "Failure", "Functional disorder", "Future", "Generations", "Genetic Transcription", "Goals", "Growth", "Homeostasis", "Immune response", "Immune system", "Immunity", "Immunologic Memory", "Impairment", "Individual", "Infection", "Inflammatory", "Influenza", "Lung", "Malignant Neoplasms", "Measures", "Memory", "Modality", "Modeling", "Monitor", "Mus", "Pathology", "Pharmaceutical Preparations", "Phase", "Phenotype", "Play", "Population", "Primary Infection", "Process", "Reporter", "Research Personnel", "Risk", "Role", "SARS-CoV-2 infection", "Serum", "Shapes", "T-Lymphocyte", "Testing", "Tissues", "Transgenic Mice", "Vaccination", "Viral Load result", "Virus", "adaptive immune response", "age related", "aged", "anti-influenza", "bone health", "chemokine", "cytokine", "disability", "effector T cell", "experience", "flu", "improved", "improved outcome", "influenza infection", "mouse model", "prevent", "programs", "response", "senescence", "single-cell RNA sequencing", "stressor", "transcriptomics", "wound healing" ], "approved": true } }, { "type": "Grant", "id": "12313", "attributes": { "award_id": "1R21ES034858-01", "title": "Prenatal endocrine-disrupting chemicals, pandemic-related stress and social risk in mothers and infants", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 12256, "first_name": "Kimberly A", "last_name": "Gray", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-15", "end_date": "2025-08-31", "award_amount": 259200, "principal_investigator": { "id": 28221, "first_name": "Beatrice A", "last_name": "Beebe", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 10605, "first_name": "Julie Beth", "last_name": "Herbstman", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] }, { "id": 12257, "first_name": "AMY", "last_name": "MARGOLIS", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [ { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true } ] } ], "awardee_organization": { "id": 781, "ror": "", "name": "COLUMBIA UNIVERSITY HEALTH SCIENCES", "address": "", "city": "", "state": "NY", "zip": "", "country": "United States", "approved": true }, "abstract": "Mother-infant (M-I) interaction sets the behavioral foundation and trajectory for infant social/cognitive development. Parental social behaviors are vulnerable to endocrine-disrupting chemicals because these behaviors are shaped by hormonal priming and the organization of the social/parental brain. In utero bisphenol A (BPA) exposure disrupts maternal care and offspring social behavior/neurobehavioral development in animals and humans. To date, the effects of BPA on M-I interaction have not been examined, one aim of our ongoing R01 ES027424. Although BPA has been removed from many consumer products, it has been replaced by structural analogs, bisphenol-s (BPS) and bisphenol-f (BPF), which may have similar detrimental effects. This study aims to translate findings from animal models to ask whether increased prenatal BPA, BPS, BPF (BP) exposure in humans predicts less optimal M-I interaction. Understanding the effects of BP on M-I interaction is essential to revealing pathways through which BP may act to disrupt neurodevelopment. We recruit women during pregnancy, assess prenatal BP exposure using multiple urine samples from the 3rd trimester of pregnancy, and assess M-I interaction with measures of sec-by-sec reciprocal M-I influences, providing a nuanced measure of the effects of BP. The COVID-19 pandemic hit NYC in March 2020, exposing new mothers to high levels of additional stress: sudden onset, world-wide impact; high death rates/levels of fear; disproportionate impact on racial/ ethnic minorities; hardships e.g. social isolation, job loss, social distancing/wearing masks, exacerbated postpartum mental health difficulties (pandemic-related stressors). Stress exacerbates the effects of chemical exposures on child health outcomes, highlighting the need to consider the impact of these additional pandemic- related stressors which may lead to pandemic-related stress (symptoms consistent with DSM-5 acute stress disorder diagnosis). In our existing R01 ES027424, data collection was halted by the pandemic and has now resumed, providing a unique opportunity and an imperative to study whether pandemic-related stress(ors) alter the association between bisphenol exposure and M-I interaction. This time-sensitive R21 collects and analyzes information aimed to determine (a) whether the social exposure of living through the pandemic alters M-I interaction, and/or alters the effects of bisphenol on M-I interaction; and (b) within the pandemic-exposed group, whether higher COVID-19 pandemic-related stress(ors) alters bisphenol exposure, and/or alters M-I interaction. Understanding how pandemic-related stress(ors) may impact M-I interaction and/or exacerbate the effects of environmental exposures on M-I interaction is essential to (i) informing clinical intervention: stress is modifiable, a potential target of public health intervention; (ii) revealing one developmental pathway through which the COVID-19 pandemic may disrupt child development, and (iii) informing medical/ public health policies in future pandemics.", "keywords": [ "Affect", "Animal Model", "Animals", "Anxiety", "Behavior", "Behavioral", "Brain", "COVID-19 pandemic", "Caring", "Chemical Exposure", "Child", "Child Care", "Child Development", "Child Health", "Clinical", "Code", "DSM-V", "Data", "Data Collection", "Death Rate", "Development", "Diagnosis", "Employment", "Endocrine Disruptors", "Endocrine disruption", "Environmental Exposure", "Exposure to", "Financial Hardship", "Food", "Foundations", "Frequencies", "Fright", "Funding", "Health Policy", "Hispanic", "Hormonal", "Household", "Human", "Infant", "Intervention", "Job loss", "Joints", "Life", "Masks", "Maternal Exposure", "Measures", "Mediating", "Medical", "Mental Health", "Mental Health Services", "Methods", "Modeling", "Mothers", "New York City", "Outcome", "Pathway interactions", "Patient Self-Report", "Pattern", "Postpartum Period", "Pregnancy", "Pregnancy Trimesters", "Pregnant Women", "Premature Infant", "Public Health", "Questionnaires", "Regulation", "Research", "Risk", "SARS-CoV-2 infection", "Sampling", "Series", "Shapes", "Social Behavior", "Social Distance", "Social isolation", "Stress", "Symptoms", "Testing", "Third Pregnancy Trimester", "Time", "Touch sensation", "Toxic Environmental Substances", "Translating", "Urine", "Visit", "Widow", "Widowhood", "Woman", "Work", "acute stress", "acute traumatic stress disorder", "analog", "behavior prediction", "bisphenol A", "cognitive development", "consumer product", "early life exposure", "ethnic minority", "experience", "future pandemic", "gaze", "in utero", "maternal depression", "member", "neurobehavioral", "neurodevelopment", "offspring", "pandemic disease", "pandemic impact", "pandemic stress", "post-pandemic", "pre-pandemic", "pregnant", "prenatal", "prospective", "psychosocial stressors", "public health intervention", "racial minority", "recruit", "social", "social organization", "social stressor", "stress symptom", "stressor", "time use" ], "approved": true } }, { "type": "Grant", "id": "12314", "attributes": { "award_id": "1R01NR021156-01", "title": "Heath Outcomes Post-Eviction Moratoria (HOPE-M)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Institute of Nursing Research (NINR)" ], "program_reference_codes": [], "program_officials": [ { "id": 6649, "first_name": "Karen", "last_name": "Huss", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-20", "end_date": "2026-06-30", "award_amount": 2360082, "principal_investigator": { "id": 28222, "first_name": "Daphne C.", "last_name": "Hernandez", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 788, "ror": "", "name": "UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON", "address": "", "city": "", "state": "TX", "zip": "", "country": "United States", "approved": true }, "abstract": "Experiencing the threat of eviction is associated with mental distress, and Black, Hispanic, and female renters are most affected by evictions. Eviction moratoria were short-term housing interventions designed to limit the spread of COVID-19 and maintain housing stability. Travis County (Austin, TX) residents experienced a strong local moratorium (i.e. blocked all stages of eviction process) through December 2021. In contrast, Harris County (Houston, TX) residents never experienced a local moratorium, and were dependent on the state moratorium, which ended in May 2020. Since moratoria have ended, evictions and the cost of basic needs have dramatically increased. In a post-moratoria period, the question remains whether prior exposure to a strong local moratorium policy reduces post-moratorium mental distress in the presence of ongoing economic disruptions. The Heath Outcomes Post-Eviction Moratoria (HOPE-M) Study, proposes to use a mixed methods sequential explanatory design to examine how prior exposure to a strong local moratorium influences the direct and indirect paths linking the threat of eviction with post-moratorium mental health over time. To create the sample 2 sources of data will be used. The first source of data will be used to identify individuals who had eviction filing post state/local moratorium (Harris: June 2020–December 2023; Travis: January 2022–December 2023). This data was collected through the Eviction Tracking System. The second source of data will facilitate identification of individuals at risk for eviction but not filed using data generated by Dr. Thomas' (co-I) Housing Precarity Risk Model (HPRM). Renters living in neighborhoods with high eviction risk after the state/local moratorium ended will be selected on matching criteria based on respondent's household characteristics that align with the top predictive variables in the HPRM (e.g., race) as well as dominate characteristics found in prior eviction research (e.g., sex). Participants [Harris County (n= 1,000) Travis County (n=1,000)] will be surveyed at baseline, 6 months, 12 months. Analyses will include longitudinal mixed effect models and focus groups and photo elicitation interviews will be used to triangulate the findings. Aim 1. Assess the moderating impact of prior local eviction policy exposure on the link between experiencing the threat of eviction and post-moratorium mental health over time and how this varies by race/ethnicity and sex. Aim 2. Examine the mental health disparities in aim 1 as a function of the mediating effects of economic hardship and psychosocial stressors. Aim 3. Explore the decision- making processes and self-assessment associated with making economic decisions to avoid eviction and how this contributes to psychosocial distress. With every state having shortage of affordable and available rental homes, this study is significant to policymakers and legal aid organizations who have the ability to inform housing policies. The use of ETS's court-ordered eviction records (over self-reports) and the use of the HPRM to include adults with similar characteristics and at-risk for eviction is an innovative approach to improving sample selection. This approach complements NIMH's Strategic Plan, Goals 2 and 3 and is supported by numerous stakeholders.", "keywords": [ "Adult", "Affect", "Anxiety", "Black race", "COVID-19", "Characteristics", "County", "Data", "Decision Making", "Discrimination", "Distress", "Economics", "Ethnic Origin", "Exposure to", "Feeling suicidal", "Female", "Focus Groups", "Food", "Food Assistance Programs", "Gender", "Genetic Complementation Test", "Goals", "Health", "Hearing", "Hispanic", "Home", "Household", "Housing", "Hunger", "Income", "Individual", "Inequity", "Interview", "Legal", "Link", "Mediating", "Mental Depression", "Mental Health", "Methods", "Modeling", "National Institute of Mental Health", "Natural Disasters", "Neighborhoods", "Outcome", "Participant", "Patient Self-Report", "Policies", "Policy Maker", "Process", "Process Assessment", "Psyche structure", "Race", "Records", "Research", "Respondent", "Risk", "Sampling", "Self Assessment", "Shelter facility", "Source", "Strategic Planning", "Surveys", "System", "Texas", "Time", "Transportation", "austin", "coronavirus disease", "cost", "court", "design", "experience", "food insecurity", "health disparity", "improved", "innovation", "insight", "male", "mental health policy", "pandemic disease", "peer", "psychosocial", "psychosocial stressors", "sex", "therapy design" ], "approved": true } }, { "type": "Grant", "id": "12315", "attributes": { "award_id": "1OT2OD035895-01", "title": "Somos Esenciales: Community Revitalization and Health through Latino Arts and Entrepreneurship", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "NIH Office of the Director" ], "program_reference_codes": [], "program_officials": [ { "id": 28223, "first_name": "Michelle R", "last_name": "Hamlet", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-20", "end_date": "2028-09-19", "award_amount": 1125000, "principal_investigator": { "id": 28224, "first_name": "Roberto Y", "last_name": "Hernandez", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2082, "ror": "", "name": "CULTURA Y ARTE NATIVA DE LAS AMERICAS", "address": "", "city": "", "state": "CA", "zip": "", "country": "United States", "approved": true }, "abstract": "Somos Esenciales: Community Revitalization and Health through Latino Arts and Entrepreneurship is a comprehensive community revitalization plan led by Cultura y Arte Nativa de Las Americas (CANA) in San Francisco’s Mission District in collaboration with government and community partners, that targets upstream social and policy determinants of health. Structural targets include combining an affordable housing/home ownership initiative, urban gardening and food distribution, harnessing economic development through transforming empty storefronts with Latino entrepreneurship, and providing culturally responsive wellness and mental healthcare. These efforts are a clear continuation and extension of CANA’s work and mission, critical for mental health (e.g., depression and anxiety), physical health (e.g., chronic illnesses such as hypertension, diabetes) and economic well-being of our families and community in a post COVID-19 recovery environment. Central to this collaborative plan is a community-based participatory action research approach with local Latino laborers, domestic workers, and cultural producers, in collaboration with professional health services researchers at UCSF, whose goal together is to identify the relationship between systemic inequities, racial disparities, and physical and mental health outcomes. CANA and its partners will utilize this research as part of the NIH Common Fund launched by the Community Partnerships to Advance Science for Society, and to create and implement a multi-platform COVID-19 recovery plan and community revitalization for Latino, Indigenous, and Black residents of San Francisco’s Mission District that brings opportunities for all to thrive through community revitalization and structural interventions focused on home ownership, food access, bilingual health and wellness, and economic workforce development.", "keywords": [ "Address", "Admission activity", "Adrenal Glands", "Affect", "American Indians", "Americas", "Anxiety", "Area", "Arts", "Black race", "Businesses", "COVID-19", "COVID-19 pandemic", "California", "Cardiovascular system", "Chronic", "Chronic Disease", "Cities", "Collaborations", "Color", "Communities", "Community Developments", "Community Workers", "Coronary Arteriosclerosis", "Development", "Diabetes Mellitus", "Dimensions", "Discrimination", "Disease", "Dyslipidemias", "Economic Development", "Economics", "Entrepreneurship", "Environment", "Essential worker", "Evaluation Research", "Family", "Food", "Food Access", "Funding", "Goals", "Government", "Health", "Health Services", "Health Status", "Home", "Hospitalization", "Housing", "Hypertension", "Hypothalamic structure", "Indigenous", "Individual", "Inequity", "Infrastructure", "Insulin Resistance", "Intensive Care Units", "Intervention", "Latino", "Latino Population", "Measurement", "Mental Depression", "Mental Health", "Mental Health Services", "Metabolic", "Mission", "Obesity", "Outcome", "Outcome Study", "Ownership", "Personal Satisfaction", "Physiological", "Policies", "Politics", "Poverty", "Property", "Public Health", "Quality of life", "Race", "Recovery", "Research", "Research Methodology", "Research Personnel", "Resources", "Risk", "Running", "San Francisco", "Scientific Advances and Accomplishments", "Stress", "Substance Use Disorder", "Testing", "United States National Institutes of Health", "Universities", "Work", "Workforce Development", "alcohol risk", "alcohol use disorder", "bilingualism", "community based participatory research", "community partnership", "environmental stressor", "epidemiology study", "evidence base", "experience", "healing", "health determinants", "health disparity", "health equity", "health inequalities", "improved", "innovation", "member", "minority communities", "neighborhood disadvantage", "pandemic disease", "physical conditioning", "post-COVID-19", "programs", "racial disparity", "racism", "science and society", "service organization", "social", "social determinants", "social disparities", "square foot", "structural health determinants" ], "approved": true } }, { "type": "Grant", "id": "12316", "attributes": { "award_id": "1R43IP001230-01", "title": "PA22-176, SBIR, Phase I, Development of a SARS-CoV-2 emerging variant infectivity and immune evasion panel to quantify the efficacy of vaccine booster induced neutralizing antibodies.", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [], "program_reference_codes": [], "program_officials": [], "start_date": "2023-09-30", "end_date": "2024-06-29", "award_amount": 273181, "principal_investigator": { "id": 28225, "first_name": "Brian", "last_name": "Hetrick", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 2083, "ror": "", "name": "VIRONGY BIOSCIENCES, INC.", "address": "", "city": "", "state": "VA", "zip": "", "country": "United States", "approved": true }, "abstract": "As the COVID19 pandemic and vaccine deployment continue there is an urgent need to monitor emerging variants for their infectivity and ability to escape both prior infection and vaccine induced neutralizing antibodies. Currently, there is no way to rapidly quantify emerging variants infectivity and immune evading capacity. The standard for quantifying viral infectivity involves the use of harvested viral isolates and performing quantitative plaque assays, which are tedious and time consuming. Additionally, the use of infectious SARS-CoV-2 requires high-level containment in BSL-3 facilities that limits its application in common clinical and research laboratories. Pseudoviruses have been widely used to model SARS-CoV-2 infectivity and antibody neutralization. Pseudoviruses, such as those derived from lentivirus and vesicular stomatitis virus, can mimic the entry process of SARS-CoV-2. However, these pseudovirions consist of mostly non-coronavirus structural proteins and require 2-3 days to generate results. Recently, a novel hybrid alphavirus-SARS-CoV-2 pseudovirion (HA-CoV-2) has been developed by the P.I. (Hetrick) for rapid (3-6 hours) and accurate quantification of viral infectivity and sensitivity to neutralizing antibodies. The HA-CoV-2 particle is a non-replicating SARS-CoV-2 virus-like particle (VLP) composed of only SARS-CoV-2 structural proteins (S, M, N, and E) and a RNA reporter genome derived from a fast expressing alphavirus vector. Our preliminary studies have demonstrated that the HA-CoV-2 assay can rapidly quantify the differences in neutralizing antibodies from vaccinated and previously infected individuals to specific SARS-CoV-2 variants. Virongy has recently licensed the HA-CoV-2 technology from George Mason University, and plans to develop commercial kits with panels of HA-CoV-2 particles that represent the SARS- CoV-2 variants currently in circulation with the greatest infectivity and potential for immune escape. As viral variants continue to emerge there is an urgent need to monitor the infectivity and evaluate the effectiveness of the vaccines on emerging variants. The HA-CoV-2 system would provide a robust platform for rapid and accurate quantification of viral variant infectivity and the neutralizing antibody response. We propose to develop a HA- CoV-2 pseudovirus-based panel to examine infectivity and neutralizing antibody response with two specific aims. Specific Aim 1 is to screen the 50 most prevalent SARS-CoV-2 variant spike proteins in circulation and identify the emerging variants with the highest infectivity using the HA-CoV-2 pseudovirus platform. Specific aim 2 is to conduct antibody neutralization assays of each COVID variant in circulation and determine the sensitivity of each variant to both vaccine and infection induced anti-serum and convalescent plasma. For this study the WHO International Standard and Reference Panel for anti-SARS-CoV-2 antibody will be screened along with a standard recombinant RBD antibody. Following the initial screening the top 5 variants will be selected to develop a commercial panel kit for vaccine and booster developers to evaluate the efficacy of their prophylactics. As part of this screening process Virongy plans to collaborate with John Hopkins university and other non-profit public health organizations to provide all the data acquired in this study. The HA-CoV-2 pseudovirus are currently marketed on Virongy’s company website (virongy.com) for research use only.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12317", "attributes": { "award_id": "1R13HS029599-01A1", "title": "Telehealth Post-Pandemic: A Roadmap for the Coming Decade", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Agency for Healthcare Research and Quality (AHRQ)" ], "program_reference_codes": [], "program_officials": [ { "id": 28226, "first_name": "Poonam", "last_name": "Pardasaney", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2024-09-29", "award_amount": 49668, "principal_investigator": { "id": 28227, "first_name": "Bree Elizabeth-Allen", "last_name": "Holtz", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 521, "ror": "https://ror.org/05hs6h993", "name": "Michigan State University", "address": "", "city": "", "state": "MI", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic necessitated the rapid implementation of telehealth, leading to limited reflection on how to sustain quality care and what permanent policies are needed for continuing these services. Therefore, the objective of this proposed conference is to convene a Think Tank to develop and disseminate best practices for providing high-quality telehealth care and promoting policy changes that support equitable access to quality, safe, and efficient healthcare for all Americans. This Think Tank will assemble a multi-disciplinary group of decision leaders from health systems, physician groups, researchers, patient advocates, technology groups, insurers, and policymakers from Michigan. Michigan is an ideal setting for this conference because of its racial, political, cultural, economic, and geographic diversity. Thus, the guidance developed through this Think Tank will be able to be translated nationally. The rationale is that this conference provides a timely opportunity for these groups to reflect on the quick shift to providing telehealth during the pandemic and chart a course for best practices and next steps to ensure its sustainability. There are two specific aims for this Think Tank: 1) Develop practice, policy, and research priorities to guide evidence-based guidelines for providing telehealth services, and 2) Actively distribute these priorities to a national audience. For the first aim, Think Tank will cultivate connections among healthcare providers, health systems, government, industry, and researchers engaged in telehealth. Through a pre-conference literature review, key topics will be developed, and workgroups will be formed to delve into the issues and document gaps and evidence-based practices. For the second aim, the team will leverage partnerships with Connect America, Blue Cross Blue Shield, and the Journal of Telemedicine and Telecare to disseminate Think Tank findings and recommendations to a national audience. The team will also disseminate findings at national conferences, through social media, and on its website to improve the use of telehealth, telehealth access, and the equitable coordination of care. The conference deliverables will include a literature review, a website including blogs and podcasts, at least six publications to be published in Telemedicine and e-Health, policy briefs, an updated telehealth curriculum, and presentations at national meetings. This contribution is significant because the work done at this Think Tank conference will directly inform policymakers’ and practice leaders’ decisions for improving telehealth solutions to provide better access and healthcare to all patients. This will have tangible impacts on and guidance for the sustained implementation of telehealth nationally.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12318", "attributes": { "award_id": "1R01HS029111-01A1", "title": "The Safety Integration Stakeholders (SAINTS) program to integrate worker and patient safety in Oregon rural hospitals", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "Agency for Healthcare Research and Quality (AHRQ)" ], "program_reference_codes": [], "program_officials": [ { "id": 28228, "first_name": "Erofile", "last_name": "Gripiotis", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-30", "end_date": "2028-08-31", "award_amount": 379224, "principal_investigator": { "id": 28229, "first_name": "David Alejandro", "last_name": "Hurtado", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 765, "ror": "https://ror.org/009avj582", "name": "Oregon Health & Science University", "address": "", "city": "", "state": "OR", "zip": "", "country": "United States", "approved": true }, "abstract": "The COVID-19 pandemic accentuated the inextricable link between worker and patient safety. Yet most hospitals have separate initiatives for either patient or worker safety. A case in point is safe patient handling and mobility (SPHM), where most programs are implemented by Employee Health and Safety without coordination with other quality or patient safety departments. This disconnect is significant because adverse and costly outcomes such as patient falls or workers’ patient-assist injuries have overlapping risk factors that must be addressed together. One promising response is through a program that integrates stakeholders, including influential front-line workers, to address overlapping risk factors for patient falls and patient-assist injuries. Our preliminary research pre-tested an integrated safety program at a rural hospital in Oregon that demonstrated 12-month effectiveness in improving leading indicators and reduction of patient-assist injury rates. The program had four main components: 1) the involvement of patient and worker safety stakeholders; 2) the innovative application of Social Network Analysis (SNA) to identify peer-recognized safety leaders instead of self- or supervisor-nominated workers who may not have the influence required to effect change; 3) training stakeholders on safety leadership, and 4) implementation of quality improvement (QI) cycles to reduce safety barriers. Based on these promising results, we plan to build a new scalable intervention to be tested in a rigorous multi-hospital trial. The objective of this proposal is to conduct a cluster randomized controlled trial in six rural hospitals to evaluate the effectiveness and process of a safety program titled Safety Integration Stakeholders (SAINTS). We will test the central hypothesis that relative to usual practice controls, the three hospitals randomly assigned to the SAINTS program will have reduced risk factors for patient falls and patient- assist injuries 12 months after the end of the program. The rationale is that the SAINTS program will positively impact outcomes by identifying and training key players on strategies to boost environmental, administrative, and educational precautions relevant to SPHM. We propose two aims: Aim 1: Determine the SAINTS' effectiveness in reducing overlapping risk factors for patient falls and patient-assist injuries. Effectiveness will be determined by surveying in-patient unit workers on risk factors for patient-assist injuries and patient falls at baseline, six months after program initiation, and 12 months after the end of implementation (primary endpoint). The trial is powered to detect changes in leading indicators, but we will also examine lagging effects on the incidence rates of patient falls, patient-assist injuries, entries in reporting systems, and staff turnover. Aim 2: Identify safety precaution measures produced by the SAINTS program. Given the semi-structured design, we will conduct a multi-method process evaluation to identify the extent to which the program was delivered as planned and if it led to the adoption of preventative measures.", "keywords": [], "approved": true } }, { "type": "Grant", "id": "12319", "attributes": { "award_id": "1R13CA281369-01A1", "title": "The 10th International MDM2 Workshop", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Cancer Institute (NCI)" ], "program_reference_codes": [], "program_officials": [ { "id": 24061, "first_name": "RUIBAI", "last_name": "Luo", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-15", "end_date": "2024-08-31", "award_amount": 15000, "principal_investigator": { "id": 28230, "first_name": "Tomoo", "last_name": "Iwakuma", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [], "awardee_organization": { "id": 1199, "ror": "", "name": "CHILDREN'S MERCY HOSP (KANSAS CITY, MO)", "address": "", "city": "", "state": "MO", "zip": "", "country": "United States", "approved": true }, "abstract": "The p53 protein is the most frequently mutated gene in human cancers and functions as a tumor suppressor by transcriptionally regulating numerous downstream target genes involved in cell cycle progression and apoptosis. MDM2 and its homolog MDM4 (also known as MDMX) are two of the most important negative regulators of p53 by acting as an E3 ubiquitin ligase complex to promote p53 degradation and by physical binding to inhibit the p53’s transcriptional function. These proteins are also overexpressed in approximately 30% of human cancers. Overexpression of MDM2/MDM4 not only inhibits p53 function, but also shows p53-independent oncogenic activities. Intriguingly, gene amplification of MDM2 and MDM4 is associated with adverse hyperprogressive response to anti-PDL1 cancer immunotherapy in a subset of patients. Thus, inhibitors for MDM2 and MDM4 have been developed to inhibit their oncogenic activities and to reactivate wild-type p53 in tumors. Importantly, some MDM2/MDM4 inhibitors are in clinical trials. The first International MDM2 Workshop, held in 2001 in the United Kingdom, was primarily in response to a significant increase in the research related to p53 and its negative regulators MDM2/MDM4, as well as strong demand for drug discovery targeting MDM2/MDM4/p53. The expansion of the scientific community studying MDM2/MDM4 and the need to pursue this area of research with a collaborative multidisciplinary approach have further made the MDM2 Workshop necessary. The MDM2 Workshop is held every two or three years, at locations alternating between the United States and Europe, to bring together the p53/MDM2 field, present the latest research, and facilitate collaboration and exchange of reagents. Indeed, both the p53 and MDM2 Workshops have become important platforms for long-term scientific exchange and new investigators of the MDM2-p53 pathway. The 10th International MDM2 Workshop will be held at an auditorium of the newly built National Cancer Center Research Institute (NCCRI) in Tokyo, Japan, on October 15-18, 2023. This will be the first International p53/MDM2 Workshop organized and held in Japan. The meeting will be co-organized by Dr. Rieko Ohki (NCCRI, Tokyo, Japan), Dr. Koji Itahana (Duke-NUS Medical School, Singapore), and Dr. Tomoo Iwakuma (Children’s Mercy Research Institute, MO, USA). Notably, due to COVID-19, we have not had the MDM2 Workshop for over 4 years, since the 9th MDM2 Workshop on November 4-7, 2018 in Florida. We expect more participants with higher enthusiasm for this 10th MDM2 Workshop, as compared with the previous MDM2 Workshops. Significant numbers of US researchers, including the international organizing committee (11 out of 16, 38% women), are expected to participate in and benefit from the meeting. Hence, we are applying for R13 funding to support this important and exciting international meeting that will energize research in US and promote scientific progress and interactions in the p53/MDM2 field. Funds are requested to support three important specific aims designed to promote participation of the US investigators and trainees.", "keywords": [ "Acetylation", "African American", "Antineoplastic Agents", "Apoptosis", "Area", "Award", "Basic Science", "Binding", "Biology", "COVID-19", "Cancer Biology", "Cancer Center", "Career Mobility", "Cell Cycle Progression", "Child", "Cities", "Clinical Research", "Clinical Trials", "Collaborations", "Communities", "Complex", "DNA Repair", "Doctor of Philosophy", "Drug Industry", "Drug Targeting", "Educational workshop", "Ensure", "Europe", "Event", "Florida", "Funding", "Gene Deletion", "Gene Mutation", "Genes", "Genetic Transcription", "Goals", "Grant", "Hispanic", "Homologous Gene", "Human", "Immunity", "In Vitro", "Individual", "International", "Japan", "Location", "MDM2 Gene Amplification", "MDM2 gene", "Malignant Neoplasms", "Mediating", "Medicine", "Mentors", "Minority", "Mutate", "NCI Center for Cancer Research", "New York", "Oncogenic", "Participant", "Pathway interactions", "Pharmaceutical Preparations", "Phosphorylation", "Play", "Postdoctoral Fellow", "Proteins", "Public Health", "Reagent", "Regulation", "Research", "Research Institute", "Research Personnel", "Role", "Scientist", "Senior Scientist", "Signal Transduction", "Singapore", "Students", "TP53 gene", "Tokyo", "Translational Research", "Travel", "Tumor Suppressor Proteins", "Ubiquitination", "Underrepresented Minority", "Underrepresented Populations", "United Kingdom", "United States", "Universities", "Up-Regulation", "Woman", "Writing", "anti-PD-L1", "anticancer research", "cancer immunotherapy", "career", "clinically relevant", "college", "design", "drug discovery", "graduate student", "in vivo", "inhibitor", "interdisciplinary approach", "man", "medical schools", "meetings", "mouse model", "overexpression", "patient subsets", "public health relevance", "response", "social", "tumor", "ubiquitin-protein ligase" ], "approved": true } }, { "type": "Grant", "id": "12320", "attributes": { "award_id": "1R01HL169533-01", "title": "Effective Primary care practices that Enhance Recovery Trajectories after pneumonia (EXPERT)", "funder": { "id": 4, "ror": "https://ror.org/01cwqze88", "name": "National Institutes of Health", "approved": true }, "funder_divisions": [ "National Heart Lung and Blood Institute (NHLBI)" ], "program_reference_codes": [], "program_officials": [ { "id": 22454, "first_name": "GUOFEI", "last_name": "Zhou", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "start_date": "2023-09-15", "end_date": "2028-06-30", "award_amount": 761577, "principal_investigator": { "id": 21554, "first_name": "Catherine Lee", "last_name": "Hough", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, "other_investigators": [ { "id": 6804, "first_name": "Stephanie P", "last_name": "Taylor", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] }, { "id": 28231, "first_name": "Theodore J", "last_name": "Iwashyna", "orcid": null, "emails": "", "private_emails": "", "keywords": null, "approved": true, "websites": null, "desired_collaboration": null, "comments": null, "affiliations": [] } ], "awardee_organization": { "id": 344, "ror": "https://ror.org/00za53h95", "name": "Johns Hopkins University", "address": "", "city": "", "state": "MD", "zip": "", "country": "United States", "approved": true }, "abstract": "Even before COVID-19, pneumonia with respiratory failure was a very common cause of hospitalization. Unfortunately, many patients who survive pneumonia have persistent health problems for months or years afterwards. The objective of this Effective Primary Care Practices that Enhance Recovery Trajectories after Pneumonia (EXPERT) study is to use appreciative inquiry to help primary care clinicians take better care of pneumonia patients in the 6 months after hospital–by taking a strengths-based approach for transformational change to design and test a new systems-level intervention. We will use a multi-methods approach wherein quantitative analysis of primary care actions and qualitative interviews with expert primary care clinicians and patients are used to refine an innovative intervention in a participatory prototyping pilot trial. The pilot trial targets mechanistic process outcomes linked to increased hospital-free days for pneumonia survivors. Our team from primary care, hospitalist medicine, critical care, palliative care, sepsis, informatics, clinical epidemiology, medical sociology, and clinical trials, will: Aim 1: Quantitatively analyze granular EHR data to identify and refine candidate components for a primary care intervention to improve post-pneumonia care. We will leverage large, feature-rich datasets from our team’s 3 diverse health systems to identify specific orders, referrals, and billing services by primary care clinicians that are substantially more frequent in the 6 months after pneumonia than before and temporally associated with reduced subsequent hospitalization. Aim 2: Qualitatively analyze the experiential insights of primary care clinicians and pneumonia survivors to identify and refine candidate components and identify enablers and barriers for the post-pneumonia intervention. We will conduct semi-structured interviews and focus groups with PCCs and pneumonia survivors across 4 states to evaluate key actions and implementation factors for successful post-pneumonia recovery. Aim 3. Refine and pilot a novel multicomponent primary care intervention to improve delivery of post-pneumonia care that will lead to improved health outcomes for pneumonia survivors. We will use a novel stakeholder-engaged strategy of participatory prototyping to iteratively optimize the intervention and evaluate its effects on target mechanistic outcomes in an eight-site cluster randomized pilot trial design. EXPERT’s research addresses a fundamental knowledge gap in post-pneumonia care, a public health priority. We propose to use appreciative inquiry to help primary care do what primary care does well, and to optimize an intervention that makes it easier for them to do so.", "keywords": [ "Address", "Advance Care Planning", "COVID-19", "Caring", "Clinical Trials", "Critical Care", "Data", "Data Set", "Disease", "Electronic Health Record", "Focus Groups", "Goals", "Health", "Health system", "Hospitalists", "Hospitalization", "Hospitals", "Informatics", "Intervention", "Interview", "Knowledge", "Link", "Malignant Neoplasms", "Measures", "Medical Sociology", "Medicine", "Methods", "Myocardial Infarction", "Outcome", "Palliative Care", "Patient-Focused Outcomes", "Patients", "Pharmaceutical Preparations", "Physical therapy", "Pneumonia", "Primary Care", "Process", "Randomized", "Recovery", "Research", "Respiratory Failure", "Sepsis", "Site", "Stroke", "Structure", "Survivors", "System", "Testing", "United States", "Work", "clinical epidemiology", "design", "experience", "follow-up", "hospital readmission", "implementation determinants", "improved", "improved outcome", "innovation", "insight", "intervention refinement", "long term recovery", "medical specialties", "novel", "pilot trial", "post-COVID-19", "pragmatic randomized trial", "primary care clinician", "primary care practice", "primary care services", "primary care team", "process improvement", "prototype", "public health priorities", "trial design", "user centered design" ], "approved": true } } ], "meta": { "pagination": { "page": 1383, "pages": 1419, "count": 14184 } } }